FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300773407> ?p ?o ?g. }

• W4300773407 abstract "Abstract Exposure to low doses of the radioactive gas radon, as found indoors in dwellings, has been consistently shown to be a risk factor for lung cancer (LC). The linear-no-threshold hypothesis (LNT) is often applied to estimate excess odds ratios or population attributable risks, albeit this LNT assumption remains debated. We investigate the profile of radon-induced LC-risk in a sample of 8,927 cases and 5,562 controls of the International Lung Cancer Consortium (ILCCO), contributed by studies with sufficient exposure heterogeneity. Spatial indoor-radon exposure in the residential area (sIR) obtained from the national surveys were linked to the participants’ residential geo-location. Parametric linear- and spline-functions were fitted within framework of logistic regression. We observed a U-shaped dose-risk relation, with the lowest risk exposure level (LRE) being 57.6 Bq/m³ (95%.CI: 56.1–59.2 Bq/m³). The risk of overall-LC at 25 Bq/m³ (OR = 1.31, 95%-CI: 1.01–1.59) was comparable to that at 100 Bq/m³ (OR = 1.34, 95%-CI: 1.20–1.45). Regarding histological subtypes, we observed the strongest risk for small-cell LC, and weak association for squamous-cell LC with no association below 58 Bq/m³. Our results showed a U-shaped risk-profile for radon-induced LC risk at very low exposure levels (sIR < 200 Bq/m³), lowest in areas of mean indoor radon levels of about 58 Bq/m³. Risk profiles differ between histological subtypes, and sex, age and smoking behaviour modify the lowest risk thresholds. sIR is a useful proxy for radon exposure, and the linearity-no-threshold assumption in this data seems not optimal for the dose-response relation of sIR less than 200 Bq/m³." @default.
• W4300773407 created "2022-10-04" @default.
• W4300773407 creator A5002857362 @default.
• W4300773407 creator A5011467039 @default.
• W4300773407 creator A5017649214 @default.
• W4300773407 creator A5019050324 @default.
• W4300773407 creator A5023531951 @default.
• W4300773407 creator A5028111106 @default.
• W4300773407 creator A5028989565 @default.
• W4300773407 creator A5034359692 @default.
• W4300773407 creator A5050433141 @default.
• W4300773407 creator A5051714662 @default.
• W4300773407 creator A5053074659 @default.
• W4300773407 creator A5053530719 @default.
• W4300773407 creator A5062526137 @default.
• W4300773407 creator A5063459619 @default.
• W4300773407 creator A5066001988 @default.
• W4300773407 creator A5066518394 @default.
• W4300773407 creator A5066835564 @default.
• W4300773407 creator A5071248262 @default.
• W4300773407 creator A5081350789 @default.
• W4300773407 date "2022-10-03" @default.
• W4300773407 modified "2023-10-02" @default.
• W4300773407 title "On the non-linearity of radon-induced lung cancer" @default.
• W4300773407 cites W1652510626 @default.
• W4300773407 cites W1934822394 @default.
• W4300773407 cites W1968242727 @default.
• W4300773407 cites W1979662427 @default.
• W4300773407 cites W1979704902 @default.
• W4300773407 cites W1986011245 @default.
• W4300773407 cites W1996629030 @default.
• W4300773407 cites W1998407519 @default.
• W4300773407 cites W2002929260 @default.
• W4300773407 cites W2005029697 @default.
• W4300773407 cites W2027597724 @default.
• W4300773407 cites W2085368712 @default.
• W4300773407 cites W2100553071 @default.
• W4300773407 cites W2104225980 @default.
• W4300773407 cites W2111723606 @default.
• W4300773407 cites W2113616286 @default.
• W4300773407 cites W2131558988 @default.
• W4300773407 cites W2132611552 @default.
• W4300773407 cites W2134715491 @default.
• W4300773407 cites W2221837786 @default.
• W4300773407 cites W2767874392 @default.
• W4300773407 cites W2772059163 @default.
• W4300773407 cites W2804092736 @default.
• W4300773407 cites W2807041642 @default.
• W4300773407 cites W2889605858 @default.
• W4300773407 cites W2895983482 @default.
• W4300773407 cites W2904776825 @default.
• W4300773407 cites W2911188335 @default.
• W4300773407 cites W2911851840 @default.
• W4300773407 cites W2914708606 @default.
• W4300773407 cites W2981519032 @default.
• W4300773407 cites W3007541248 @default.
• W4300773407 cites W3040508871 @default.
• W4300773407 cites W3044058140 @default.
• W4300773407 cites W3110866001 @default.
• W4300773407 cites W3115019252 @default.
• W4300773407 cites W3126930341 @default.
• W4300773407 cites W3136618233 @default.
• W4300773407 cites W3164301847 @default.
• W4300773407 cites W3175417087 @default.
• W4300773407 cites W3187513969 @default.
• W4300773407 cites W4214666033 @default.
• W4300773407 cites W4238260078 @default.
• W4300773407 doi "https://doi.org/10.21203/rs.3.rs-1933741/v2" @default.
• W4300773407 hasPublicationYear "2022" @default.
• W4300773407 type Work @default.
• W4300773407 citedByCount "0" @default.
• W4300773407 crossrefType "posted-content" @default.
• W4300773407 hasAuthorship W4300773407A5002857362 @default.
• W4300773407 hasAuthorship W4300773407A5011467039 @default.
• W4300773407 hasAuthorship W4300773407A5017649214 @default.
• W4300773407 hasAuthorship W4300773407A5019050324 @default.
• W4300773407 hasAuthorship W4300773407A5023531951 @default.
• W4300773407 hasAuthorship W4300773407A5028111106 @default.
• W4300773407 hasAuthorship W4300773407A5028989565 @default.
• W4300773407 hasAuthorship W4300773407A5034359692 @default.
• W4300773407 hasAuthorship W4300773407A5050433141 @default.
• W4300773407 hasAuthorship W4300773407A5051714662 @default.
• W4300773407 hasAuthorship W4300773407A5053074659 @default.
• W4300773407 hasAuthorship W4300773407A5053530719 @default.
• W4300773407 hasAuthorship W4300773407A5062526137 @default.
• W4300773407 hasAuthorship W4300773407A5063459619 @default.
• W4300773407 hasAuthorship W4300773407A5066001988 @default.
• W4300773407 hasAuthorship W4300773407A5066518394 @default.
• W4300773407 hasAuthorship W4300773407A5066835564 @default.
• W4300773407 hasAuthorship W4300773407A5071248262 @default.
• W4300773407 hasAuthorship W4300773407A5081350789 @default.
• W4300773407 hasBestOaLocation W43007734071 @default.
• W4300773407 hasConcept C121332964 @default.
• W4300773407 hasConcept C126322002 @default.
• W4300773407 hasConcept C144024400 @default.
• W4300773407 hasConcept C149923435 @default.
• W4300773407 hasConcept C151956035 @default.
• W4300773407 hasConcept C156957248 @default.
• W4300773407 hasConcept C2776256026 @default.
• W4300773407 hasConcept C2908647359 @default.

• next