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- W4300781670 abstract "Integrated mechanisms of regulation of energy metabolism at cellular, tissue, and organ levels are analyzed from a systems biology perspective. These integrated mechanisms comprise the coordinated function of three cycles of mass and energy transfer and conversion: (1) the Randle cycle of substrate supply, (2) the Krebs cycle coupled with energy transformation in mitochondrial oxidative phosphorylation, and (3) the kinase cycles of intracellular energy transfer and signal transduction for regulation of energy fluxes. These cycles are extended and partially governed by information transfer systems like those linked to protein kinase signaling. In the heart, these cycles are closely related to the Ca2+ cycle during excitation–contraction coupling. According to the view of integrated metabolic cycles, the phosphocreatine/creatine kinase system represents a most important subsystem determining the efficiency of regulation of metabolic and energy fluxes in heart, brain, and oxidative skeletal muscles. It carries about 80 % of the energy flux between mitochondria and cytoplasm in heart. The substrate uptake, respiration rate, and energy fluxes are regulated in response to workload via phosphotransfer pathways and Ca2+ cycling. We propose integrated network mechanisms to explain the linear relationship between myocardial oxygen consumption and heart work output under conditions of metabolic stability (metabolic aspect of Frank–Starling’s law of the heart). The efficiency of energy transfer, force of contraction, and metabolic regulation of respiration and energy fluxes depend upon the intracellular concentration of total creatine, which is decreased in heart failure. The role of creatine, creatine kinase, and adenylate kinase phosphotransfer and AMP-activated protein kinase (AMPK) signaling systems and their interrelationship with substrate supply and Ca2+ cycles are analyzed. Finally, an introduction to the AMPK signaling network is provided with a particular emphasis on the heart in health and disease." @default.
- W4300781670 created "2022-10-04" @default.
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- W4300781670 date "2013-08-05" @default.
- W4300781670 modified "2023-10-17" @default.
- W4300781670 title "Systems Level Regulation of Cardiac Energy Fluxes Via Metabolic Cycles: Role of Creatine, Phosphotransfer Pathways, and AMPK Signaling" @default.
- W4300781670 cites W112706938 @default.
- W4300781670 cites W1502440948 @default.
- W4300781670 cites W1538613429 @default.
- W4300781670 cites W1547061112 @default.
- W4300781670 cites W1554653315 @default.
- W4300781670 cites W1555165800 @default.
- W4300781670 cites W1565979608 @default.
- W4300781670 cites W1567345519 @default.
- W4300781670 cites W1568822320 @default.
- W4300781670 cites W1572067593 @default.
- W4300781670 cites W1576151387 @default.
- W4300781670 cites W1596136472 @default.
- W4300781670 cites W1596427554 @default.
- W4300781670 cites W1598394864 @default.
- W4300781670 cites W1607014413 @default.
- W4300781670 cites W1697383903 @default.
- W4300781670 cites W177033108 @default.
- W4300781670 cites W1827729646 @default.
- W4300781670 cites W1849159432 @default.
- W4300781670 cites W185383216 @default.
- W4300781670 cites W185449676 @default.
- W4300781670 cites W1861099352 @default.
- W4300781670 cites W1864895841 @default.
- W4300781670 cites W1876043561 @default.
- W4300781670 cites W1944999268 @default.
- W4300781670 cites W1964429750 @default.
- W4300781670 cites W1964976203 @default.
- W4300781670 cites W1966040370 @default.
- W4300781670 cites W1966700598 @default.
- W4300781670 cites W1967667786 @default.
- W4300781670 cites W1968484082 @default.
- W4300781670 cites W1969252317 @default.
- W4300781670 cites W1969852589 @default.
- W4300781670 cites W1970205234 @default.
- W4300781670 cites W1970637701 @default.
- W4300781670 cites W1970745048 @default.
- W4300781670 cites W1970917581 @default.
- W4300781670 cites W1971919543 @default.
- W4300781670 cites W1972275394 @default.
- W4300781670 cites W1973055037 @default.
- W4300781670 cites W1973622869 @default.
- W4300781670 cites W1974086756 @default.
- W4300781670 cites W1974870493 @default.
- W4300781670 cites W1975387345 @default.
- W4300781670 cites W1976701283 @default.
- W4300781670 cites W1978278112 @default.
- W4300781670 cites W1978608872 @default.
- W4300781670 cites W1978763812 @default.
- W4300781670 cites W1979439323 @default.
- W4300781670 cites W1981502020 @default.
- W4300781670 cites W1981526622 @default.
- W4300781670 cites W1981785619 @default.
- W4300781670 cites W1982043127 @default.
- W4300781670 cites W1982221711 @default.
- W4300781670 cites W1983066766 @default.
- W4300781670 cites W1983195734 @default.
- W4300781670 cites W1983834588 @default.
- W4300781670 cites W1985539815 @default.
- W4300781670 cites W1985569448 @default.
- W4300781670 cites W1985934685 @default.
- W4300781670 cites W1986375719 @default.
- W4300781670 cites W1987698712 @default.
- W4300781670 cites W1989693351 @default.
- W4300781670 cites W1990278643 @default.
- W4300781670 cites W1993239107 @default.
- W4300781670 cites W1993544886 @default.
- W4300781670 cites W1994041994 @default.
- W4300781670 cites W1994995334 @default.
- W4300781670 cites W1995278218 @default.
- W4300781670 cites W1995336211 @default.
- W4300781670 cites W1998877815 @default.
- W4300781670 cites W2000233707 @default.
- W4300781670 cites W2000707691 @default.
- W4300781670 cites W2001568034 @default.
- W4300781670 cites W2003226017 @default.
- W4300781670 cites W2004814508 @default.
- W4300781670 cites W2006332285 @default.
- W4300781670 cites W2007114641 @default.
- W4300781670 cites W2007545368 @default.
- W4300781670 cites W2008904009 @default.
- W4300781670 cites W2009263255 @default.
- W4300781670 cites W2009700086 @default.