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- W4300785250 abstract "Preliminary sampling among the population of the Central African Republic suggested a wide genetic variation of HIV-1 subtypes, which indicated multiple introductions of human immunodeficiency virus (HIV) into the country. In response to these findings, Dr. Timothy J. Dondero of the U.S. Centers for Disease Control and Prevention led a multicenter group that examined the epidemiologic patterns of HIV-1 in the Central African Republic. 2250 individuals from 17 sites in 10 cities were tested and typed for human immunodeficiency virus (HIV). The overall seroprevalence of HIV-1 ranged from 2.7% to 30.7%. The highest prevalence rate was found among sexually transmitted disease clinic attenders (25.3% to 30.7%), while the rate among women attending prenatal clinics ranged from 5% to 16.7%. Many of the specimens were reactive to multiple peptides; 9% recognized none of the peptides and may represent more divergent HIV-1 strains. No HIV-2 or divergent HIV-1 group O infections were found. The extremely wide pattern of serologic reactivity among HIV-1 infected persons suggests a very heterogenous distribution of HIV-1 strains in the republic and may be important for the development of vaccines to be used in the region. The Central African Republic borders on 5 other African countries and contains a major highway that connects other countries; the potential for further HIV spread is great." @default.
- W4300785250 created "2022-10-04" @default.
- W4300785250 date "1996-08-19" @default.
- W4300785250 modified "2023-10-18" @default.
- W4300785250 title "HIV-1 epidemic and public health threat in Central African Republic." @default.
- W4300785250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12291508" @default.
- W4300785250 hasPublicationYear "1996" @default.
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