FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300817908> ?p ?o ?g. }

• W4300817908 endingPage "13" @default.
• W4300817908 startingPage "1" @default.
• W4300817908 abstract "To explore the mechanisms of TLR9 from macrophages on mitochondrial apoptosis in cardiomyocytes at early stage of sepsis.The in vivo and in vitro sepsis mice were bone marrow transplantation (BMT) with wild type (WT) or (toll-like receptor 9) TLR9 knockout (-/- or KO) myeloid cells and then constructed by cecum ligation and puncture (CLP) as vivo experiment and cardiomyocytes cocultured with WT or TLR9-deficient macrophages treated with LPS as vitro experiment, respectively. Sepsis model were performed by CLP. The expression levels of exosome, PI3K/AKT, and ERK1/2, inflammatory factors, and apoptotic proteins were tested by western blot in vivo. Besides, associated apoptotic proteins and JC-1 fluorescence assay were tested in vitro.The expressions of p-PI3K, p-AKT, exosome markers (CD9, CD63, and TSG101), p-ERK1/2, TNF-α, IFN-γ, IL-1β, and cleaved-caspase-3/-9 were significantly increased in septic mice vs. control mice, and these proteins were declined dramatically in TLR9-/- BMT mice vs. WT BMT mice in sepsis mice models. Meanwhile, the protein expression of cytochrome C, cleaved-caspase-3, and cleaved-caspase-9 increased significantly in primary mouse myocardial cells cocultured with TLR9-/- or WT macrophages stimulated with LPS, and these mitochondrial apoptotic proteins as well as the green 5,5',6,6'-tetrachloro-1,1',3,3'- tetraethylbenzimidazolcarbocyanine iodide (JC-1) fluorescence were dramatically lower in LPS-stimulated cardiomyocytes cocultured with TLR9-/- than with WT macrophages.TLR9-/- in macrophages suppressed the inflammatory reaction as well as the exosome secretion and resulted in the inhibition of apoptosis and oxidative stress in sepsis-induced cardiomyopathy." @default.
• W4300817908 created "2022-10-04" @default.
• W4300817908 creator A5005865976 @default.
• W4300817908 creator A5006809747 @default.
• W4300817908 creator A5007717169 @default.
• W4300817908 creator A5021449466 @default.
• W4300817908 creator A5033172297 @default.
• W4300817908 creator A5034484688 @default.
• W4300817908 creator A5040908982 @default.
• W4300817908 creator A5051331455 @default.
• W4300817908 creator A5057773321 @default.
• W4300817908 creator A5075124334 @default.
• W4300817908 date "2022-10-03" @default.
• W4300817908 modified "2023-10-16" @default.
• W4300817908 title "Macrophage-Derived Exosomes in TLR9-/- Mice Ameliorate Sepsis-Induced Mitochondrial Oxidative Stress and Apoptosis in Cardiomyocytes" @default.
• W4300817908 cites W1967313871 @default.
• W4300817908 cites W1976632147 @default.
• W4300817908 cites W1980860859 @default.
• W4300817908 cites W1994274264 @default.
• W4300817908 cites W2004773897 @default.
• W4300817908 cites W2005188483 @default.
• W4300817908 cites W2005745212 @default.
• W4300817908 cites W2006919847 @default.
• W4300817908 cites W2011255130 @default.
• W4300817908 cites W2024213130 @default.
• W4300817908 cites W2046026467 @default.
• W4300817908 cites W2051521992 @default.
• W4300817908 cites W2080503511 @default.
• W4300817908 cites W2144589352 @default.
• W4300817908 cites W2257342069 @default.
• W4300817908 cites W2278600110 @default.
• W4300817908 cites W2329637972 @default.
• W4300817908 cites W2340953831 @default.
• W4300817908 cites W2761809676 @default.
• W4300817908 cites W2804904679 @default.
• W4300817908 cites W2893455740 @default.
• W4300817908 cites W2896658278 @default.
• W4300817908 cites W2965083728 @default.
• W4300817908 cites W3082432828 @default.
• W4300817908 cites W3091773414 @default.
• W4300817908 cites W3110559714 @default.
• W4300817908 cites W3117028850 @default.
• W4300817908 cites W3121368045 @default.
• W4300817908 cites W3143081127 @default.
• W4300817908 cites W3150145644 @default.
• W4300817908 cites W3158293819 @default.
• W4300817908 cites W3172161742 @default.
• W4300817908 cites W3177218861 @default.
• W4300817908 cites W3177338122 @default.
• W4300817908 cites W3177627501 @default.
• W4300817908 cites W3184458665 @default.
• W4300817908 cites W3186138748 @default.
• W4300817908 cites W3191752190 @default.
• W4300817908 cites W3201389987 @default.
• W4300817908 cites W4210531301 @default.
• W4300817908 doi "https://doi.org/10.1155/2022/5719974" @default.
• W4300817908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36225174" @default.
• W4300817908 hasPublicationYear "2022" @default.
• W4300817908 type Work @default.
• W4300817908 citedByCount "8" @default.
• W4300817908 countsByYear W43008179082023 @default.
• W4300817908 crossrefType "journal-article" @default.
• W4300817908 hasAuthorship W4300817908A5005865976 @default.
• W4300817908 hasAuthorship W4300817908A5006809747 @default.
• W4300817908 hasAuthorship W4300817908A5007717169 @default.
• W4300817908 hasAuthorship W4300817908A5021449466 @default.
• W4300817908 hasAuthorship W4300817908A5033172297 @default.
• W4300817908 hasAuthorship W4300817908A5034484688 @default.
• W4300817908 hasAuthorship W4300817908A5040908982 @default.
• W4300817908 hasAuthorship W4300817908A5051331455 @default.
• W4300817908 hasAuthorship W4300817908A5057773321 @default.
• W4300817908 hasAuthorship W4300817908A5075124334 @default.
• W4300817908 hasBestOaLocation W43008179081 @default.
• W4300817908 hasConcept C104317684 @default.
• W4300817908 hasConcept C150194340 @default.
• W4300817908 hasConcept C150903083 @default.
• W4300817908 hasConcept C153911025 @default.
• W4300817908 hasConcept C185592680 @default.
• W4300817908 hasConcept C190283241 @default.
• W4300817908 hasConcept C190727270 @default.
• W4300817908 hasConcept C207001950 @default.
• W4300817908 hasConcept C2779138994 @default.
• W4300817908 hasConcept C55493867 @default.
• W4300817908 hasConcept C75217442 @default.
• W4300817908 hasConcept C86803240 @default.
• W4300817908 hasConcept C95444343 @default.
• W4300817908 hasConceptScore W4300817908C104317684 @default.
• W4300817908 hasConceptScore W4300817908C150194340 @default.
• W4300817908 hasConceptScore W4300817908C150903083 @default.
• W4300817908 hasConceptScore W4300817908C153911025 @default.
• W4300817908 hasConceptScore W4300817908C185592680 @default.
• W4300817908 hasConceptScore W4300817908C190283241 @default.
• W4300817908 hasConceptScore W4300817908C190727270 @default.
• W4300817908 hasConceptScore W4300817908C207001950 @default.
• W4300817908 hasConceptScore W4300817908C2779138994 @default.
• W4300817908 hasConceptScore W4300817908C55493867 @default.
• W4300817908 hasConceptScore W4300817908C75217442 @default.
• W4300817908 hasConceptScore W4300817908C86803240 @default.

• next