FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300830266> ?p ?o ?g. }

• W4300830266 endingPage "7427" @default.
• W4300830266 startingPage "7416" @default.
• W4300830266 abstract "The dopamine (DA) transporter is thought to be the primary mediator of reinforcing effects of cocaine. In the present study, an intravenous drug self-administration procedure, in vitro autoradiography, and HPLC methods were used to investigate possible differences in reinforcing and neuroadaptive responses to cocaine versus GBR-12909, a selective inhibitor of the DA transporter with a postulated therapeutic use in cocaine abuse. Drug-naive rats readily acquired and subsequently maintained cocaine self-administration behavior during 2 hr daily sessions over a prolonged period. In contrast, although GBR-12909 was initially self-administered, both cocaine-naive and cocaine-trained rats failed to maintain self-administration behavior for GBR-12909 over prolonged periods of time. After self-administration responding decreased with GBR-12909, rats showed a delay of 6.6 ± 1.3 sessions in reacquiring consistent cocaine self-administration. Moreover, when GBR-12909 was again substituted for cocaine, they failed to self-administer GBR-12909, even during the initial days of testing. In contrast, after extinction of self-administration responding by water substitution, rats readily self-administered both cocaine and GBR-12909. Cocaine self-administration upregulated DA transporters, whereas water-substituted cocaine withdrawal upregulated both DA transporters and D1 receptors. Unlike cocaine, GBR-12909 self-administration by itself altered neither DA transporters nor D1 or D2 receptors. Nevertheless, substitution of GBR-12909 for cocaine reversed the cocaine-induced upregulation of DA transporters and reduced DA and dihydroxyphenylacetic acid levels in the mesolimbic system. These data suggest that cocaine and GBR-12909 differentially affect dopaminergic systems and also cause different reinforcing and neuroadaptive effects. GBR-12909-like compounds may be useful pharmacotherapeutic agents for cocaine addiction. Upregulation of DA transporters and D1 receptors might play important roles in the neuroadaptive cascade that leads to cocaine addiction and withdrawal." @default.
• W4300830266 created "2022-10-04" @default.
• W4300830266 creator A5006888475 @default.
• W4300830266 creator A5038787070 @default.
• W4300830266 creator A5043772835 @default.
• W4300830266 creator A5054655637 @default.
• W4300830266 creator A5058938189 @default.
• W4300830266 date "1996-12-01" @default.
• W4300830266 modified "2023-10-17" @default.
• W4300830266 title "Differential Reinforcing Effects of Cocaine and GBR-12909: Biochemical Evidence for Divergent Neuroadaptive Changes in the Mesolimbic Dopaminergic System" @default.
• W4300830266 cites W1513242235 @default.
• W4300830266 cites W1514724839 @default.
• W4300830266 cites W1653336699 @default.
• W4300830266 cites W1775749144 @default.
• W4300830266 cites W1916293712 @default.
• W4300830266 cites W1964996895 @default.
• W4300830266 cites W1967987600 @default.
• W4300830266 cites W1974037468 @default.
• W4300830266 cites W1974692779 @default.
• W4300830266 cites W1975912352 @default.
• W4300830266 cites W1977391309 @default.
• W4300830266 cites W1980020955 @default.
• W4300830266 cites W1980839482 @default.
• W4300830266 cites W1989092292 @default.
• W4300830266 cites W1991597488 @default.
• W4300830266 cites W1993792324 @default.
• W4300830266 cites W2001599905 @default.
• W4300830266 cites W2001865657 @default.
• W4300830266 cites W2002711099 @default.
• W4300830266 cites W2007604257 @default.
• W4300830266 cites W2009243814 @default.
• W4300830266 cites W2009772097 @default.
• W4300830266 cites W2013177064 @default.
• W4300830266 cites W2013195522 @default.
• W4300830266 cites W2015745154 @default.
• W4300830266 cites W2020879088 @default.
• W4300830266 cites W2021032401 @default.
• W4300830266 cites W2026545036 @default.
• W4300830266 cites W2029516351 @default.
• W4300830266 cites W2034490236 @default.
• W4300830266 cites W2037320367 @default.
• W4300830266 cites W2045019814 @default.
• W4300830266 cites W2048960532 @default.
• W4300830266 cites W2062061883 @default.
• W4300830266 cites W2063752616 @default.
• W4300830266 cites W2076815003 @default.
• W4300830266 cites W2077707065 @default.
• W4300830266 cites W2080684572 @default.
• W4300830266 cites W2080922934 @default.
• W4300830266 cites W2083302537 @default.
• W4300830266 cites W2087948459 @default.
• W4300830266 cites W2093348357 @default.
• W4300830266 cites W2103312011 @default.
• W4300830266 cites W3024135912 @default.
• W4300830266 cites W4243093913 @default.
• W4300830266 cites W4319293053 @default.
• W4300830266 cites W2014360159 @default.
• W4300830266 doi "https://doi.org/10.1523/jneurosci.16-23-07416.1996" @default.
• W4300830266 hasPublicationYear "1996" @default.
• W4300830266 type Work @default.
• W4300830266 citedByCount "63" @default.
• W4300830266 countsByYear W43008302662012 @default.
• W4300830266 countsByYear W43008302662014 @default.
• W4300830266 countsByYear W43008302662015 @default.
• W4300830266 countsByYear W43008302662016 @default.
• W4300830266 countsByYear W43008302662019 @default.
• W4300830266 countsByYear W43008302662022 @default.
• W4300830266 countsByYear W43008302662023 @default.
• W4300830266 crossrefType "journal-article" @default.
• W4300830266 hasAuthorship W4300830266A5006888475 @default.
• W4300830266 hasAuthorship W4300830266A5038787070 @default.
• W4300830266 hasAuthorship W4300830266A5043772835 @default.
• W4300830266 hasAuthorship W4300830266A5054655637 @default.
• W4300830266 hasAuthorship W4300830266A5058938189 @default.
• W4300830266 hasBestOaLocation W43008302661 @default.
• W4300830266 hasConcept C104317684 @default.
• W4300830266 hasConcept C137183658 @default.
• W4300830266 hasConcept C149011108 @default.
• W4300830266 hasConcept C15744967 @default.
• W4300830266 hasConcept C169760540 @default.
• W4300830266 hasConcept C185592680 @default.
• W4300830266 hasConcept C2776755682 @default.
• W4300830266 hasConcept C2778555786 @default.
• W4300830266 hasConcept C2779177272 @default.
• W4300830266 hasConcept C2781161787 @default.
• W4300830266 hasConcept C2908949072 @default.
• W4300830266 hasConcept C2909816965 @default.
• W4300830266 hasConcept C31487548 @default.
• W4300830266 hasConcept C513476851 @default.
• W4300830266 hasConcept C55493867 @default.
• W4300830266 hasConcept C71924100 @default.
• W4300830266 hasConcept C98274493 @default.
• W4300830266 hasConceptScore W4300830266C104317684 @default.
• W4300830266 hasConceptScore W4300830266C137183658 @default.
• W4300830266 hasConceptScore W4300830266C149011108 @default.
• W4300830266 hasConceptScore W4300830266C15744967 @default.
• W4300830266 hasConceptScore W4300830266C169760540 @default.
• W4300830266 hasConceptScore W4300830266C185592680 @default.

• next