Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300861161> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4300861161 abstract "<p> </p> <p><strong>Objective</strong>: To examine the effect of different patterns of durable glycemic control on the development of comorbidities among youth with type 2 diabetes and to assess the impact of fasting glucose variability on the clinical course of type 2 diabetes.</p> <p><strong>Research Design and Methods</strong>: 457 TODAY participants, mean age 14 years and diabetes duration <2 years at entry, and a minimum study follow-up of 10 years were included in these analyses. HbA1c, fasting glucose concentrations, and beta-cell function estimates from oral glucose tolerance tests were measured longitudinally. Prevalence of comorbidities by glycemic control status after 10 years in the TODAY study was assessed.</p> <p><strong>Results</strong>: Higher baseline HbA1c concentration, lower beta-cell function, and maternal history of diabetes were strongly associated with loss of glycemic control in youth with type 2 diabetes. Higher cumulative HbA1c concentration over 4 years and greater fasting glucose variability over a year’s time within 3 years of diagnosis were related to higher prevalence of dyslipidemia, nephropathy, and retinopathy progression over the subsequent 10 years. A coefficient of variability in fasting glucose at or above 8.3% predicted future loss of glycemic control and development of comorbidities.</p> <p><strong>Conclusions</strong>: Higher baseline HbA1c concentration and fasting glucose variability during year 1 accurately predicted youth with type 2 diabetes who will experience metabolic decompensation and comorbidities and may be useful tools for clinicians when considering early intensification of therapy.</p>" @default.
- W4300861161 created "2022-10-04" @default.
- W4300861161 creator A5009340358 @default.
- W4300861161 creator A5019684802 @default.
- W4300861161 creator A5029781521 @default.
- W4300861161 creator A5047948839 @default.
- W4300861161 creator A5052719172 @default.
- W4300861161 creator A5055241891 @default.
- W4300861161 creator A5066340728 @default.
- W4300861161 creator A5069145647 @default.
- W4300861161 creator A5074296348 @default.
- W4300861161 creator A5075497407 @default.
- W4300861161 creator A5090956937 @default.
- W4300861161 date "2022-10-03" @default.
- W4300861161 modified "2023-09-23" @default.
- W4300861161 title "Long-Term Outcomes Among Young Adults with Type 2 Diabetes Based on Durability of Glycemic Control: Results from the TODAY Cohort Study" @default.
- W4300861161 doi "https://doi.org/10.2337/figshare.20732785" @default.
- W4300861161 hasPublicationYear "2022" @default.
- W4300861161 type Work @default.
- W4300861161 citedByCount "0" @default.
- W4300861161 crossrefType "posted-content" @default.
- W4300861161 hasAuthorship W4300861161A5009340358 @default.
- W4300861161 hasAuthorship W4300861161A5019684802 @default.
- W4300861161 hasAuthorship W4300861161A5029781521 @default.
- W4300861161 hasAuthorship W4300861161A5047948839 @default.
- W4300861161 hasAuthorship W4300861161A5052719172 @default.
- W4300861161 hasAuthorship W4300861161A5055241891 @default.
- W4300861161 hasAuthorship W4300861161A5066340728 @default.
- W4300861161 hasAuthorship W4300861161A5069145647 @default.
- W4300861161 hasAuthorship W4300861161A5074296348 @default.
- W4300861161 hasAuthorship W4300861161A5075497407 @default.
- W4300861161 hasAuthorship W4300861161A5090956937 @default.
- W4300861161 hasBestOaLocation W43008611611 @default.
- W4300861161 hasConcept C126322002 @default.
- W4300861161 hasConcept C134018914 @default.
- W4300861161 hasConcept C2777180221 @default.
- W4300861161 hasConcept C2777185836 @default.
- W4300861161 hasConcept C2778096610 @default.
- W4300861161 hasConcept C2780473172 @default.
- W4300861161 hasConcept C2780609358 @default.
- W4300861161 hasConcept C555293320 @default.
- W4300861161 hasConcept C71924100 @default.
- W4300861161 hasConcept C72563966 @default.
- W4300861161 hasConceptScore W4300861161C126322002 @default.
- W4300861161 hasConceptScore W4300861161C134018914 @default.
- W4300861161 hasConceptScore W4300861161C2777180221 @default.
- W4300861161 hasConceptScore W4300861161C2777185836 @default.
- W4300861161 hasConceptScore W4300861161C2778096610 @default.
- W4300861161 hasConceptScore W4300861161C2780473172 @default.
- W4300861161 hasConceptScore W4300861161C2780609358 @default.
- W4300861161 hasConceptScore W4300861161C555293320 @default.
- W4300861161 hasConceptScore W4300861161C71924100 @default.
- W4300861161 hasConceptScore W4300861161C72563966 @default.
- W4300861161 hasLocation W43008611611 @default.
- W4300861161 hasLocation W43008611612 @default.
- W4300861161 hasOpenAccess W4300861161 @default.
- W4300861161 hasPrimaryLocation W43008611611 @default.
- W4300861161 hasRelatedWork W2003439778 @default.
- W4300861161 hasRelatedWork W2023154173 @default.
- W4300861161 hasRelatedWork W2040354749 @default.
- W4300861161 hasRelatedWork W2163945438 @default.
- W4300861161 hasRelatedWork W2354032276 @default.
- W4300861161 hasRelatedWork W3173391483 @default.
- W4300861161 hasRelatedWork W4238936064 @default.
- W4300861161 hasRelatedWork W4246931643 @default.
- W4300861161 hasRelatedWork W4300190787 @default.
- W4300861161 hasRelatedWork W58885054 @default.
- W4300861161 isParatext "false" @default.
- W4300861161 isRetracted "false" @default.
- W4300861161 workType "article" @default.