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- W4300905782 abstract "Colorectal cancer (CRC) features high prevalence and mortality. Long non-coding RNAs (lncRNAs) exert nonnegligible roles in human cancer development. Nevertheless, the functions of most lncRNAs still remain unexplored. We currently focused on detecting the influence of SPINT1 antisense RNA 1 (SPINT1-AS1) on CRC development and investigating into the potential regulatory mechanism. RT-qPCR analysis first confirmed that SPINT1-AS1 exhibited high expression in KRAS-mutant (KRASMUT) CRC cells. Through series of functional experiments, we observed that knockdown of SPINT1-AS1 weakened KRASMUT CRC cell proliferation, migration and invasion. Afterwards, the implementation of mechanism assays help to verify that SPINT1-AS1 sequestered microRNA-433–3p (miR-433–3p) to regulate the expression of E2F transcription factor 3 (E2F3). Besides, E2F3 was validated to activate the transcription of SPINT1-AS1 in turn. Rescue experiments confirmed the functional influence of SPINT1-AS1/miR-433–3p/E2F3 on CRC cells. In summary, the molecular axis of SPINT1-AS1/miR-433–3p/E2F3 forms a positive loop which might become a potential biomarker in CRC." @default.
- W4300905782 created "2022-10-04" @default.
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- W4300905782 date "2022-11-01" @default.
- W4300905782 modified "2023-09-28" @default.
- W4300905782 title "LncRNA SPINT1-AS1/miR-433–3p/E2F3 positive feedback loop promotes the KRAS-mutant colorectal cancer cell proliferation, migration and invasion" @default.
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- W4300905782 doi "https://doi.org/10.1016/j.prp.2022.154064" @default.
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