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- W4300960097 abstract "Abstract Despite their importance for immunity against sexually transmitted infections (STIs), the composition of the female reproductive tract (FRT) memory CD4 T cell population in response to changes in the local tissue environment during the menstrual cycle remains poorly defined. Here we show that across humans, non-human primates (NHP), and mice, FRT CD4 T cells comprise distinct subsets corresponding to migratory memory (T MM ) and resident memory (T RM ) cells. T MM display tissue-itinerant trafficking characteristics, restricted FRT tissue distribution, with distinct transcriptional properties and effector responses to infection. CD4 T cell subset fluctuations synchronized with cycle-driven proinflammatory changes within the local tissue environment and oral administration of a CCR5 antagonist inhibited cycle phase-specific migratory T cell surveillance. This study provides novel insights into the dynamic nature of FRT memory CD4 T cells and identifies the menstrual cycle as a key regulator of memory T cell defense at the site of STI exposure. Summary The menstrual cycle regulates memory T cell surveillance." @default.
- W4300960097 created "2022-10-04" @default.
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- W4300960097 date "2022-10-03" @default.
- W4300960097 modified "2023-10-15" @default.
- W4300960097 title "Memory CD4 T cell subset organization in the female reproductive tract is regulated via the menstrual cycle through CCR5 signaling" @default.
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- W4300960097 doi "https://doi.org/10.1101/2022.10.01.510445" @default.
- W4300960097 hasPublicationYear "2022" @default.
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