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- W4300961632 endingPage "109119" @default.
- W4300961632 startingPage "109119" @default.
- W4300961632 abstract "Here, we report a synthetic approach to hetero-steroids and also studied their biological activities as anticancer agents. A novel class of oxacycles containing estrone moiety were synthesized in this report. Allyl ether derived from estrone underwent Claisen rearrangement (CR) and again O-allylation and subsequent ring-closure gave A-ring-furan and oxepine fused derivatives in high yields. We used double bond isomerization and ring-closing metathesis (RCM) as key steps to assemble hetero steroids containing a mixture of regio isomers like benzofurans and benzoxepine moieties. The novel benzofuran and benzoxepine-based hybrid steroid derivatives were subjected to in vitro cytotoxicity analysis and were found to exert cancer cell-specific activity." @default.
- W4300961632 created "2022-10-04" @default.
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- W4300961632 date "2022-12-01" @default.
- W4300961632 modified "2023-09-29" @default.
- W4300961632 title "Design and synthesis of hetero-steroids via ring-closing metathesis: Biological studies towards in vitro anticancer activity" @default.
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- W4300961632 doi "https://doi.org/10.1016/j.steroids.2022.109119" @default.
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