FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300962005> ?p ?o ?g. }

• W4300962005 abstract "Background: Lung adenocarcinoma (LUAD) is a life-threatening malignant tumor, contributing for the largest cancer burden worldwide. Tumor microenvironment (TME) is composed of various immune cells, stromal cells and tumor cells, which is highly associated with the cancer prognosis and the response to immunotherapy, in which macrophages in TME have been revealing a potential target for cancer treatment. In this study, we sought to further explore the role of macrophages in LUAD progression and establish a risk model related to macrophages for LUAD. Methods: We explored immune-related pathways that might be affected by counting positively associated genes in macrophages. Molecular typing was also constructed by mining macrophage-associated genes with prognostic value through COX regression and other analyses. RiskScore prognostic models were constructed using lasso regression and stepwise multifactorial regression analysis. The differences on clinical characteristics among three subtypes (C1, C2, and C3) and RiskScore subtypes were analyzed in TCGA dataset. Immunological algorithms such as TIMER, ssGSEA, MCP-Counter, ESTIMATE, and TIDE were used to calculate the level of difference in immune infiltration between the different subtypes. The TCGA mutation dataset processed by mutect2 was used to demonstrate the frequency of mutations between different molecular subtypes. Finally, nomograms, calibration curves, and decision curves were created to assess the predictive accuracy and reliability of the model. Results: The C1 subtype demonstrated the best prognostic outcome, accompanied by higher levels of immune infiltration and lower mutation frequency, while the majority of patients in the C1 subtype were women under 65 years of age. Myeloid-derived suppressor cell (MDSC) scores were higher in the C3 subtype, suggesting a more severe immune escape, which may have contributed to the tumor evading the immune system resulting in a poorer prognosis for patients. In addition, our RiskScore prognostic model had good predictive accuracy and reliability. Conclusion: This paper provides a study of macrophage-related pathways, immunosuppression, and their mechanisms of action in lung cancer, along with targets for future treatment to guide the optimal treatment of lung cancer." @default.
• W4300962005 created "2022-10-04" @default.
• W4300962005 creator A5032738927 @default.
• W4300962005 creator A5040091526 @default.
• W4300962005 creator A5052441498 @default.
• W4300962005 creator A5058578822 @default.
• W4300962005 creator A5089077945 @default.
• W4300962005 creator A5091727986 @default.
• W4300962005 date "2022-10-03" @default.
• W4300962005 modified "2023-10-05" @default.
• W4300962005 title "Macrophage-related molecular subtypes in lung adenocarcinoma identify novel tumor microenvironment with prognostic and therapeutic implications" @default.
• W4300962005 cites W1974412768 @default.
• W4300962005 cites W2019764524 @default.
• W4300962005 cites W2035618305 @default.
• W4300962005 cites W2058648826 @default.
• W4300962005 cites W2114586150 @default.
• W4300962005 cites W2115462905 @default.
• W4300962005 cites W2129992678 @default.
• W4300962005 cites W2130430382 @default.
• W4300962005 cites W2146512944 @default.
• W4300962005 cites W2159707944 @default.
• W4300962005 cites W2206527692 @default.
• W4300962005 cites W2230320310 @default.
• W4300962005 cites W2339573327 @default.
• W4300962005 cites W2593335250 @default.
• W4300962005 cites W2742515757 @default.
• W4300962005 cites W2748596787 @default.
• W4300962005 cites W2765224588 @default.
• W4300962005 cites W2786355530 @default.
• W4300962005 cites W2792450878 @default.
• W4300962005 cites W2796207838 @default.
• W4300962005 cites W2886498337 @default.
• W4300962005 cites W2912492964 @default.
• W4300962005 cites W2936414047 @default.
• W4300962005 cites W2949273159 @default.
• W4300962005 cites W2999417355 @default.
• W4300962005 cites W3119784685 @default.
• W4300962005 cites W3128646645 @default.
• W4300962005 cites W4210675777 @default.
• W4300962005 cites W4229334088 @default.
• W4300962005 cites W4284885053 @default.
• W4300962005 doi "https://doi.org/10.3389/fgene.2022.1012164" @default.
• W4300962005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36263430" @default.
• W4300962005 hasPublicationYear "2022" @default.
• W4300962005 type Work @default.
• W4300962005 citedByCount "0" @default.
• W4300962005 crossrefType "journal-article" @default.
• W4300962005 hasAuthorship W4300962005A5032738927 @default.
• W4300962005 hasAuthorship W4300962005A5040091526 @default.
• W4300962005 hasAuthorship W4300962005A5052441498 @default.
• W4300962005 hasAuthorship W4300962005A5058578822 @default.
• W4300962005 hasAuthorship W4300962005A5089077945 @default.
• W4300962005 hasAuthorship W4300962005A5091727986 @default.
• W4300962005 hasBestOaLocation W43009620051 @default.
• W4300962005 hasConcept C121608353 @default.
• W4300962005 hasConcept C126322002 @default.
• W4300962005 hasConcept C143998085 @default.
• W4300962005 hasConcept C16930146 @default.
• W4300962005 hasConcept C203014093 @default.
• W4300962005 hasConcept C2776107976 @default.
• W4300962005 hasConcept C2776256026 @default.
• W4300962005 hasConcept C2777701055 @default.
• W4300962005 hasConcept C2781182431 @default.
• W4300962005 hasConcept C34626388 @default.
• W4300962005 hasConcept C502942594 @default.
• W4300962005 hasConcept C50382708 @default.
• W4300962005 hasConcept C71924100 @default.
• W4300962005 hasConcept C86803240 @default.
• W4300962005 hasConcept C8891405 @default.
• W4300962005 hasConceptScore W4300962005C121608353 @default.
• W4300962005 hasConceptScore W4300962005C126322002 @default.
• W4300962005 hasConceptScore W4300962005C143998085 @default.
• W4300962005 hasConceptScore W4300962005C16930146 @default.
• W4300962005 hasConceptScore W4300962005C203014093 @default.
• W4300962005 hasConceptScore W4300962005C2776107976 @default.
• W4300962005 hasConceptScore W4300962005C2776256026 @default.
• W4300962005 hasConceptScore W4300962005C2777701055 @default.
• W4300962005 hasConceptScore W4300962005C2781182431 @default.
• W4300962005 hasConceptScore W4300962005C34626388 @default.
• W4300962005 hasConceptScore W4300962005C502942594 @default.
• W4300962005 hasConceptScore W4300962005C50382708 @default.
• W4300962005 hasConceptScore W4300962005C71924100 @default.
• W4300962005 hasConceptScore W4300962005C86803240 @default.
• W4300962005 hasConceptScore W4300962005C8891405 @default.
• W4300962005 hasLocation W43009620051 @default.
• W4300962005 hasLocation W43009620052 @default.
• W4300962005 hasLocation W43009620053 @default.
• W4300962005 hasOpenAccess W4300962005 @default.
• W4300962005 hasPrimaryLocation W43009620051 @default.
• W4300962005 hasRelatedWork W2920996053 @default.
• W4300962005 hasRelatedWork W2953174154 @default.
• W4300962005 hasRelatedWork W3015340136 @default.
• W4300962005 hasRelatedWork W3028822667 @default.
• W4300962005 hasRelatedWork W3080602383 @default.
• W4300962005 hasRelatedWork W3095136102 @default.
• W4300962005 hasRelatedWork W3169892223 @default.
• W4300962005 hasRelatedWork W3193159030 @default.
• W4300962005 hasRelatedWork W4206088420 @default.
• W4300962005 hasRelatedWork W4286629873 @default.
• W4300962005 hasVolume "13" @default.

• next