FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300962022> ?p ?o ?g. }

• W4300962022 abstract "Embryonic development is a complex phenomenon that integrates genetic regulation and biomechanical cellular behaviors. However, the relative influence of these factors on spatiotemporal morphogen distributions is not well understood. Bone Morphogenetic Proteins (BMPs) are the primary morphogens guiding the dorsal-ventral (DV) patterning of the early zebrafish embryo, and BMP signaling is regulated by a network of extracellular and intracellular factors that impact the range and signaling of BMP ligands. Recent advances in understanding the mechanism of pattern formation support a source-sink mechanism, however, it is not clear how the source-sink mechanism shapes the morphogen patterns in three-dimensional (3D) space, nor how sensitive the pattern is to biophysical rates and boundary conditions along both the anteroposterior (AP) and DV axes of the embryo, nor how the patterns are controlled over time. Throughout blastulation and gastrulation, major cell movement, known as epiboly, happens along with the BMP-mediated DV patterning. The layer of epithelial cells begins to thin as they spread toward the vegetal pole of the embryo until it has completely engulfed the yolk cell. This dynamic domain may influence the distributions of BMP network members through advection. We developed a Finite Element Model (FEM) that incorporates all stages of zebrafish embryonic development data and solves the advection-diffusion-reaction Partial Differential Equations (PDE) in a growing domain. We use the model to investigate mechanisms in underlying BMP-driven DV patterning during epiboly. Solving the PDE is computationally expensive for parameter exploration. To overcome this obstacle, we developed a Neural Network (NN) metamodel of the 3D embryo that is accurate and fast and provided a nonlinear map between high-dimensional input and output that replaces the direct numerical simulation of the PDEs. From the modeling and acceleration by the NN metamodels, we identified the impact of advection on patterning and the influence of the dynamic expression level of regulators on the BMP signaling network." @default.
• W4300962022 created "2022-10-04" @default.
• W4300962022 creator A5000927257 @default.
• W4300962022 creator A5013146110 @default.
• W4300962022 creator A5024376067 @default.
• W4300962022 creator A5030594584 @default.
• W4300962022 creator A5056101043 @default.
• W4300962022 creator A5056184390 @default.
• W4300962022 date "2022-10-03" @default.
• W4300962022 modified "2023-10-17" @default.
• W4300962022 title "Determining the role of advection in patterning by bone morphogenetic proteins through neural network model-based acceleration of a 3D finite element model of the zebrafish embryo" @default.
• W4300962022 cites W1480578144 @default.
• W4300962022 cites W1959073095 @default.
• W4300962022 cites W1979518793 @default.
• W4300962022 cites W1986960611 @default.
• W4300962022 cites W1990324466 @default.
• W4300962022 cites W1990782395 @default.
• W4300962022 cites W1992859895 @default.
• W4300962022 cites W1994808961 @default.
• W4300962022 cites W1996709598 @default.
• W4300962022 cites W1998342476 @default.
• W4300962022 cites W2031312855 @default.
• W4300962022 cites W2037961284 @default.
• W4300962022 cites W2041416094 @default.
• W4300962022 cites W2044615295 @default.
• W4300962022 cites W2046648305 @default.
• W4300962022 cites W2047346477 @default.
• W4300962022 cites W2063646605 @default.
• W4300962022 cites W2063995187 @default.
• W4300962022 cites W2093150604 @default.
• W4300962022 cites W2106133121 @default.
• W4300962022 cites W2128584428 @default.
• W4300962022 cites W2153336711 @default.
• W4300962022 cites W2743660457 @default.
• W4300962022 cites W2752387148 @default.
• W4300962022 cites W2952432038 @default.
• W4300962022 cites W2963701805 @default.
• W4300962022 cites W2990964025 @default.
• W4300962022 cites W3008834654 @default.
• W4300962022 cites W3021249357 @default.
• W4300962022 cites W3064293923 @default.
• W4300962022 cites W3103091954 @default.
• W4300962022 cites W3145703358 @default.
• W4300962022 cites W3161060415 @default.
• W4300962022 cites W3204525294 @default.
• W4300962022 cites W819639811 @default.
• W4300962022 doi "https://doi.org/10.3389/fsysb.2022.983372" @default.
• W4300962022 hasPublicationYear "2022" @default.
• W4300962022 type Work @default.
• W4300962022 citedByCount "0" @default.
• W4300962022 crossrefType "journal-article" @default.
• W4300962022 hasAuthorship W4300962022A5000927257 @default.
• W4300962022 hasAuthorship W4300962022A5013146110 @default.
• W4300962022 hasAuthorship W4300962022A5024376067 @default.
• W4300962022 hasAuthorship W4300962022A5030594584 @default.
• W4300962022 hasAuthorship W4300962022A5056101043 @default.
• W4300962022 hasAuthorship W4300962022A5056184390 @default.
• W4300962022 hasBestOaLocation W43009620221 @default.
• W4300962022 hasConcept C104317684 @default.
• W4300962022 hasConcept C129536746 @default.
• W4300962022 hasConcept C196843134 @default.
• W4300962022 hasConcept C2776133846 @default.
• W4300962022 hasConcept C2776878037 @default.
• W4300962022 hasConcept C2778386714 @default.
• W4300962022 hasConcept C54355233 @default.
• W4300962022 hasConcept C6047887 @default.
• W4300962022 hasConcept C86803240 @default.
• W4300962022 hasConcept C87073359 @default.
• W4300962022 hasConcept C92375311 @default.
• W4300962022 hasConcept C95444343 @default.
• W4300962022 hasConceptScore W4300962022C104317684 @default.
• W4300962022 hasConceptScore W4300962022C129536746 @default.
• W4300962022 hasConceptScore W4300962022C196843134 @default.
• W4300962022 hasConceptScore W4300962022C2776133846 @default.
• W4300962022 hasConceptScore W4300962022C2776878037 @default.
• W4300962022 hasConceptScore W4300962022C2778386714 @default.
• W4300962022 hasConceptScore W4300962022C54355233 @default.
• W4300962022 hasConceptScore W4300962022C6047887 @default.
• W4300962022 hasConceptScore W4300962022C86803240 @default.
• W4300962022 hasConceptScore W4300962022C87073359 @default.
• W4300962022 hasConceptScore W4300962022C92375311 @default.
• W4300962022 hasConceptScore W4300962022C95444343 @default.
• W4300962022 hasFunder F4320306076 @default.
• W4300962022 hasFunder F4320306080 @default.
• W4300962022 hasLocation W43009620221 @default.
• W4300962022 hasOpenAccess W4300962022 @default.
• W4300962022 hasPrimaryLocation W43009620221 @default.
• W4300962022 hasRelatedWork W1484104795 @default.
• W4300962022 hasRelatedWork W1608892398 @default.
• W4300962022 hasRelatedWork W1978806262 @default.
• W4300962022 hasRelatedWork W1983869846 @default.
• W4300962022 hasRelatedWork W2020215746 @default.
• W4300962022 hasRelatedWork W2025589534 @default.
• W4300962022 hasRelatedWork W2028266962 @default.
• W4300962022 hasRelatedWork W2044374208 @default.
• W4300962022 hasRelatedWork W2116414895 @default.
• W4300962022 hasRelatedWork W4253240584 @default.
• W4300962022 hasVolume "2" @default.
• W4300962022 isParatext "false" @default.
• W4300962022 isRetracted "false" @default.

• next