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- W4300962230 abstract "Abstract Homeostatic control of sleep is typically addressed through mechanical stimulation-induced forced wakefulness and the measurement of subsequent increases in sleep. A major confound attends this approach: biological responses to deprivation may reflect a direct response to the mechanical insult rather than to the loss of sleep. Similar confounds accompany all forms of sleep deprivation and represent a major challenge to the field. Here we describe a new paradigm for sleep deprivation in Drosophila that fully accounts for sleep-independent effects. Our results reveal that deep sleep states are the primary target of homeostatic control and establish the presence of multi-cycle sleep rebound following deprivation. Furthermore, we establish that specific deprivation of deep sleep state results in state-specific homeostatic rebound. Finally, by accounting for the molecular effects of mechanical stimulation during deprivation experiments, we show that serotonin levels track sleep pressure in the fly’s central brain. Our results illustrate the critical need to control for sleep-independent effects of deprivation when examining the molecular correlates of sleep pressure and call for a critical reassessment of work that has not accounted for such non-specific effects." @default.
- W4300962230 created "2022-10-04" @default.
- W4300962230 creator A5029414238 @default.
- W4300962230 creator A5044662708 @default.
- W4300962230 creator A5065763536 @default.
- W4300962230 creator A5071348573 @default.
- W4300962230 creator A5083734817 @default.
- W4300962230 date "2022-10-02" @default.
- W4300962230 modified "2023-10-16" @default.
- W4300962230 title "Homeostatic Control of Deep Sleep in<i>Drosophila</i>: Implications for Discovering Correlates of Sleep Pressure" @default.
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