Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300962507> ?p ?o ?g. }
- W4300962507 endingPage "231" @default.
- W4300962507 startingPage "211" @default.
- W4300962507 abstract "Here, through this review, we aim to serve this purpose by first discussing the statistics and aging demographics, including the life expectancy of the world and India, along with the gender life expectancy gap observed throughout the world, followed by explaining the hallmarks and integral causes of aging, along with the role played by senescent cells in controlling inflammation and the effect of senescence associated secretory phenotype on longevity. A few of the molecular pathways which are crucial in modulating the process of aging, such as the nutrient-sensing mTOR pathway, insulin signaling, Nrf2, FOXO, PI3-Akt, Sirtuins, and AMPK, and their effects are also covered in paramount detail. A diverse number of ingenious research methodologies are used in the modern era of longevity exploration. We have attempted to cover these methods under the umbrella of three broad categories: in vitro, in vivo, and in silico techniques. The drugs developed to attenuate the aging process, such as rapamycin, metformin, resveratrol, etc. and their interactions with the above-mentioned molecular pathways along with their toxicity have also been reviewed in detail." @default.
- W4300962507 created "2022-10-04" @default.
- W4300962507 creator A5029296826 @default.
- W4300962507 creator A5031534595 @default.
- W4300962507 creator A5053599815 @default.
- W4300962507 creator A5065215030 @default.
- W4300962507 creator A5089542471 @default.
- W4300962507 date "2022-09-01" @default.
- W4300962507 modified "2023-10-14" @default.
- W4300962507 title "We are all aging, and here's why" @default.
- W4300962507 cites W1487197708 @default.
- W4300962507 cites W1489084548 @default.
- W4300962507 cites W1502440948 @default.
- W4300962507 cites W1523693806 @default.
- W4300962507 cites W1531341733 @default.
- W4300962507 cites W1593284523 @default.
- W4300962507 cites W1710323544 @default.
- W4300962507 cites W1804670053 @default.
- W4300962507 cites W1840302677 @default.
- W4300962507 cites W1856482210 @default.
- W4300962507 cites W1932056767 @default.
- W4300962507 cites W1965507724 @default.
- W4300962507 cites W1965766554 @default.
- W4300962507 cites W1968133491 @default.
- W4300962507 cites W1969408132 @default.
- W4300962507 cites W1973302180 @default.
- W4300962507 cites W1974961331 @default.
- W4300962507 cites W1978183586 @default.
- W4300962507 cites W1988591365 @default.
- W4300962507 cites W2000757997 @default.
- W4300962507 cites W2001686534 @default.
- W4300962507 cites W2006937382 @default.
- W4300962507 cites W2007114641 @default.
- W4300962507 cites W2009630088 @default.
- W4300962507 cites W2010583480 @default.
- W4300962507 cites W2012222058 @default.
- W4300962507 cites W2012895942 @default.
- W4300962507 cites W2013781597 @default.
- W4300962507 cites W2014366212 @default.
- W4300962507 cites W2015392958 @default.
- W4300962507 cites W2033261332 @default.
- W4300962507 cites W2034201098 @default.
- W4300962507 cites W2046366486 @default.
- W4300962507 cites W2047072639 @default.
- W4300962507 cites W2048376025 @default.
- W4300962507 cites W2050717118 @default.
- W4300962507 cites W2053292780 @default.
- W4300962507 cites W2057247058 @default.
- W4300962507 cites W2057933983 @default.
- W4300962507 cites W2060814375 @default.
- W4300962507 cites W2071243776 @default.
- W4300962507 cites W2071485264 @default.
- W4300962507 cites W2072615530 @default.
- W4300962507 cites W2073738531 @default.
- W4300962507 cites W2075614768 @default.
- W4300962507 cites W2075763304 @default.
- W4300962507 cites W2076053153 @default.
- W4300962507 cites W2082603625 @default.
- W4300962507 cites W2084273215 @default.
- W4300962507 cites W2088381487 @default.
- W4300962507 cites W2089109086 @default.
- W4300962507 cites W2102646072 @default.
- W4300962507 cites W2103450921 @default.
- W4300962507 cites W2106189739 @default.
- W4300962507 cites W2108210710 @default.
- W4300962507 cites W2111322904 @default.
- W4300962507 cites W2122034403 @default.
- W4300962507 cites W2125121177 @default.
- W4300962507 cites W2130016073 @default.
- W4300962507 cites W2144600435 @default.
- W4300962507 cites W2147369819 @default.
- W4300962507 cites W2147501289 @default.
- W4300962507 cites W2149042028 @default.
- W4300962507 cites W2150369735 @default.
- W4300962507 cites W2152036317 @default.
- W4300962507 cites W2153607816 @default.
- W4300962507 cites W2154406648 @default.
- W4300962507 cites W2156563694 @default.
- W4300962507 cites W2162711901 @default.
- W4300962507 cites W2163379406 @default.
- W4300962507 cites W2163557631 @default.
- W4300962507 cites W2167065616 @default.
- W4300962507 cites W2168486424 @default.
- W4300962507 cites W2216310786 @default.
- W4300962507 cites W2343193821 @default.
- W4300962507 cites W2407702061 @default.
- W4300962507 cites W2427895239 @default.
- W4300962507 cites W2469298590 @default.
- W4300962507 cites W2470958832 @default.
- W4300962507 cites W2492399915 @default.
- W4300962507 cites W2545316817 @default.
- W4300962507 cites W2577597748 @default.
- W4300962507 cites W2593515715 @default.
- W4300962507 cites W2620847152 @default.
- W4300962507 cites W2622837392 @default.
- W4300962507 cites W2743539805 @default.
- W4300962507 cites W2744720876 @default.
- W4300962507 cites W2751676921 @default.