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• W4300963100 abstract "Women older than 60 have a higher risk of dementia, aging-related cognitive decline, and Alzheimer's Disease (AD) than the rest of the population. The main reason is hormonal senescence after menopause, a period characterized by a decline in estrogen levels. Since the effectiveness of drugs currently approved for the treatment of AD is limited, it is necessary to seek the development of new therapeutic strategies. Vitamin D deficiency is prevalent in AD patients and individuals with dementia in general. The supplementation of this vitamin in dementia patients might be an interesting approach for increasing the effectiveness of pre-existing medications for dementia treatment. Thus, the present study aims to investigate the effect of vitamin D treatment associated with memantine and donepezil in female mice submitted to ovariectomy (OVX) for five months and subjected to a dementia animal model induced by intracerebroventricular injection of aggregated amyloid βeta (Aβ1–42). For this purpose, Balb/c mice were divided into five experimental groups, which received 17 days of combined therapy with vitamin D, donepezil, and memantine. Then, animals were subjected to behavioral tests. OVX groups exhibited reduced levels of estradiol (E2) in serum, which was not altered by the combined therapy. Higher levels of vitamin D3 were found in the OVX animals submitted to the triple-association treatment. Mice exposed to both OVX and the dementia animal model presented impairment in short and long-term spatial and habituation memories. Also, female mice exposed to Aβ and OVX exhibited a reduction in brain-derived neurotrophic factor (BDNF) and interleukin-4 (IL-4) levels, and an increase in tumor necrose factor-α (TNFα) levels in the hippocampus. Besides, increased levels of IL-1β in the hippocampus and cerebral cortex were observed, as well as a significant increase in immunoreactivity for glial fibrillary acidic protein (GFAP), an astrocytes marker, in the hippocampus. Notably, triple-association treatment reversed the effects of the exposition of mice to Aβ and OVX in the long-term spatial and habituation memories impairment, as well as reversed changes in TNFα, IL-1β, IL-4, and GFAP immunoreactivity levels in the hippocampus of treated animals. Our results indicate that the therapeutic association of vitamin D, memantine, and donepezil has beneficial effects on memory performance and attenuated the neuroinflammatory response in female mice subjected to OVX associated with a dementia animal model." @default.
• W4300963100 created "2022-10-04" @default.
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• W4300963100 date "2023-03-01" @default.
• W4300963100 modified "2023-09-29" @default.
• W4300963100 title "Neuroprotective effects of combined therapy with memantine, donepezil, and vitamin D in ovariectomized female mice subjected to dementia model" @default.
• W4300963100 cites W1147961199 @default.
• W4300963100 cites W1582666826 @default.
• W4300963100 cites W1803418897 @default.
• W4300963100 cites W1841850981 @default.
• W4300963100 cites W1856438126 @default.
• W4300963100 cites W1866481396 @default.
• W4300963100 cites W1872738283 @default.
• W4300963100 cites W1970783145 @default.
• W4300963100 cites W1977007818 @default.
• W4300963100 cites W1978528899 @default.
• W4300963100 cites W1982326735 @default.
• W4300963100 cites W1984139645 @default.
• W4300963100 cites W1990368582 @default.
• W4300963100 cites W1994221276 @default.
• W4300963100 cites W1997927649 @default.
• W4300963100 cites W2009172873 @default.
• W4300963100 cites W2009576287 @default.
• W4300963100 cites W2017391227 @default.
• W4300963100 cites W2018197246 @default.
• W4300963100 cites W2019786269 @default.
• W4300963100 cites W2020639149 @default.
• W4300963100 cites W2021740591 @default.
• W4300963100 cites W2024356223 @default.
• W4300963100 cites W2026938853 @default.
• W4300963100 cites W2026970282 @default.
• W4300963100 cites W2026999193 @default.
• W4300963100 cites W2027439763 @default.
• W4300963100 cites W2037380525 @default.
• W4300963100 cites W2037414384 @default.
• W4300963100 cites W2038003980 @default.
• W4300963100 cites W2045854356 @default.
• W4300963100 cites W2045879711 @default.
• W4300963100 cites W2056646757 @default.
• W4300963100 cites W2061880413 @default.
• W4300963100 cites W2067907026 @default.
• W4300963100 cites W2071340676 @default.
• W4300963100 cites W2075650045 @default.
• W4300963100 cites W2078556521 @default.
• W4300963100 cites W2093526720 @default.
• W4300963100 cites W2095458493 @default.
• W4300963100 cites W2102033735 @default.
• W4300963100 cites W2105911160 @default.
• W4300963100 cites W2108149698 @default.
• W4300963100 cites W2111598959 @default.
• W4300963100 cites W2112674245 @default.
• W4300963100 cites W2124646091 @default.
• W4300963100 cites W2128453973 @default.
• W4300963100 cites W2129629659 @default.
• W4300963100 cites W2132806643 @default.
• W4300963100 cites W2145362000 @default.
• W4300963100 cites W2150399991 @default.
• W4300963100 cites W2151001476 @default.
• W4300963100 cites W2151986987 @default.
• W4300963100 cites W2156938957 @default.
• W4300963100 cites W2161273513 @default.
• W4300963100 cites W2168729560 @default.
• W4300963100 cites W2178222651 @default.
• W4300963100 cites W2211347503 @default.
• W4300963100 cites W2257469891 @default.
• W4300963100 cites W2264369089 @default.
• W4300963100 cites W2289147497 @default.
• W4300963100 cites W2291039355 @default.
• W4300963100 cites W2344223180 @default.
• W4300963100 cites W2416147422 @default.
• W4300963100 cites W2462234872 @default.
• W4300963100 cites W2462949500 @default.
• W4300963100 cites W2471914735 @default.
• W4300963100 cites W2520428971 @default.
• W4300963100 cites W2554957493 @default.
• W4300963100 cites W2574461435 @default.
• W4300963100 cites W2598570847 @default.
• W4300963100 cites W2600128417 @default.
• W4300963100 cites W2612770185 @default.
• W4300963100 cites W2732645863 @default.
• W4300963100 cites W2737900099 @default.
• W4300963100 cites W2754334814 @default.
• W4300963100 cites W2766184965 @default.

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