FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300963144> ?p ?o ?g. }

• W4300963144 abstract "Re-emerging zoonotic pathogen Brucella spp. continues to impact developing countries and persists in expanding populations of wildlife species in the US, constantly threatening infection of our domestic herds. The development of improved animal and human vaccines remains a priority. In this study, immunity to a novel live attenuated B. melitensis strain, termed znBM-mC, was characterized. An oral prime, intranasal (IN) boost strategy conferred exquisite protection against pulmonary challenge, with wild-type (wt) B. melitensis providing nearly complete protection in the lungs and spleens from brucellae colonization. Vaccination with znBM-mC showed an IFN-γ+ CD8+ T-cell bias in the lungs as opposed to Rev 1-vaccinated mice showing IFN-γ+ CD4+ T-cell inclination. Lung CD4+ and CD8+ effector memory T cells (TEMs) increased over 200-fold; and lung CD4+ and CD8+ resident memory T cells (TRMs) increased more than 250- and 150-fold, respectively. These T cells served as the primary producers of IFN-γ in the lungs, which was essential for vaccine clearance and the predominant cytokine generated pre-and post-challenge with wt B. melitensis 16M; znBM-mC growth could not be arrested in IFN-γ-/- mice. Increases in lung TNF-α and IL-17 were also induced, with IL-17 being mostly derived from CD4+ T cells. Vaccination of CD4-/-, CD8-/-, and B6 mice with znBM-mC conferred full protection in the lungs and spleens post-pulmonary challenge with virulent B. melitensis; vaccination of IL-17-/- mice resulted in the protection of the lungs, but not the spleen. These data demonstrate the efficacy of mucosal vaccine administration for the generation of protective memory T cells against wt B. melitensis." @default.
• W4300963144 created "2022-10-04" @default.
• W4300963144 creator A5014310365 @default.
• W4300963144 creator A5046169464 @default.
• W4300963144 creator A5054119420 @default.
• W4300963144 creator A5057356831 @default.
• W4300963144 date "2022-10-03" @default.
• W4300963144 modified "2023-09-25" @default.
• W4300963144 title "Live mucosal vaccination stimulates potent protection via varied CD4+ and CD8+ T cell subsets against wild-type Brucella melitensis 16M challenge" @default.
• W4300963144 cites W1967837360 @default.
• W4300963144 cites W1972485638 @default.
• W4300963144 cites W1975122757 @default.
• W4300963144 cites W1975477582 @default.
• W4300963144 cites W198266743 @default.
• W4300963144 cites W1988026832 @default.
• W4300963144 cites W1994685015 @default.
• W4300963144 cites W2000719958 @default.
• W4300963144 cites W2002024993 @default.
• W4300963144 cites W2004107049 @default.
• W4300963144 cites W2020622845 @default.
• W4300963144 cites W2031636664 @default.
• W4300963144 cites W2036002192 @default.
• W4300963144 cites W2042723023 @default.
• W4300963144 cites W2098033265 @default.
• W4300963144 cites W2109638965 @default.
• W4300963144 cites W2113597455 @default.
• W4300963144 cites W2120692442 @default.
• W4300963144 cites W2122040960 @default.
• W4300963144 cites W2133176880 @default.
• W4300963144 cites W2133758259 @default.
• W4300963144 cites W2133774846 @default.
• W4300963144 cites W2134274670 @default.
• W4300963144 cites W2135715402 @default.
• W4300963144 cites W2135847852 @default.
• W4300963144 cites W2142622505 @default.
• W4300963144 cites W2143984070 @default.
• W4300963144 cites W2144088333 @default.
• W4300963144 cites W2153484185 @default.
• W4300963144 cites W2160439166 @default.
• W4300963144 cites W2163846354 @default.
• W4300963144 cites W2167016442 @default.
• W4300963144 cites W2170016151 @default.
• W4300963144 cites W2188979598 @default.
• W4300963144 cites W219521842 @default.
• W4300963144 cites W2237942997 @default.
• W4300963144 cites W2273021913 @default.
• W4300963144 cites W2301640802 @default.
• W4300963144 cites W2327762713 @default.
• W4300963144 cites W2332938139 @default.
• W4300963144 cites W2398491744 @default.
• W4300963144 cites W2413999048 @default.
• W4300963144 cites W2520352594 @default.
• W4300963144 cites W2774520620 @default.
• W4300963144 cites W2775972683 @default.
• W4300963144 cites W2782656592 @default.
• W4300963144 cites W2791749859 @default.
• W4300963144 cites W2896612255 @default.
• W4300963144 cites W2903124759 @default.
• W4300963144 cites W2958214722 @default.
• W4300963144 cites W2999621125 @default.
• W4300963144 cites W3034360725 @default.
• W4300963144 cites W3154941305 @default.
• W4300963144 cites W3180988699 @default.
• W4300963144 cites W335465506 @default.
• W4300963144 cites W4211033510 @default.
• W4300963144 cites W47302122 @default.
• W4300963144 doi "https://doi.org/10.3389/fimmu.2022.995327" @default.
• W4300963144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36263034" @default.
• W4300963144 hasPublicationYear "2022" @default.
• W4300963144 type Work @default.
• W4300963144 citedByCount "2" @default.
• W4300963144 countsByYear W43009631442022 @default.
• W4300963144 countsByYear W43009631442023 @default.
• W4300963144 crossrefType "journal-article" @default.
• W4300963144 hasAuthorship W4300963144A5014310365 @default.
• W4300963144 hasAuthorship W4300963144A5046169464 @default.
• W4300963144 hasAuthorship W4300963144A5054119420 @default.
• W4300963144 hasAuthorship W4300963144A5057356831 @default.
• W4300963144 hasBestOaLocation W43009631441 @default.
• W4300963144 hasConcept C104317684 @default.
• W4300963144 hasConcept C126322002 @default.
• W4300963144 hasConcept C159047783 @default.
• W4300963144 hasConcept C167672396 @default.
• W4300963144 hasConcept C203014093 @default.
• W4300963144 hasConcept C22070199 @default.
• W4300963144 hasConcept C2776090121 @default.
• W4300963144 hasConcept C2777692091 @default.
• W4300963144 hasConcept C2777714996 @default.
• W4300963144 hasConcept C2779341262 @default.
• W4300963144 hasConcept C2780767784 @default.
• W4300963144 hasConcept C2780931953 @default.
• W4300963144 hasConcept C2781429187 @default.
• W4300963144 hasConcept C54602769 @default.
• W4300963144 hasConcept C55493867 @default.
• W4300963144 hasConcept C60987743 @default.
• W4300963144 hasConcept C71924100 @default.
• W4300963144 hasConcept C86803240 @default.
• W4300963144 hasConcept C8891405 @default.
• W4300963144 hasConceptScore W4300963144C104317684 @default.
• W4300963144 hasConceptScore W4300963144C126322002 @default.

• next