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- W4300978877 abstract "Peripheral neuroblastic tumors (PNTs) represent a spectrum of neural-crest-derived tumors, including neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. Malignant cells in PNTs are theorized to interconvert between adrenergic/noradrenergic and mesenchymal/neural crest cell states. Here, single-cell RNA-sequencing analysis of 10 PNTs demonstrates extensive transcriptomic heterogeneity. Trajectory modeling suggests that malignant neuroblasts move between adrenergic and mesenchymal cell states via an intermediate state that we term transitional. Transitional cells express programs linked to a sympathoadrenal development and aggressive tumor phenotypes such as rapid proliferation and tumor dissemination. Among primary bulk tumor patient cohorts, high expression of the transitional gene signature is predictive of poor prognosis compared with adrenergic and mesenchymal expression patterns. High transitional gene expression in neuroblastoma cell lines identifies a similar transitional H3K27-acetylation super-enhancer landscape. Collectively, our study supports the concept that PNTs have phenotypic plasticity and uncovers potential biomarkers and therapeutic targets." @default.
- W4300978877 created "2022-10-04" @default.
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- W4300978877 date "2022-10-01" @default.
- W4300978877 modified "2023-10-17" @default.
- W4300978877 title "Single-cell profiling of peripheral neuroblastic tumors identifies an aggressive transitional state that bridges an adrenergic-mesenchymal trajectory" @default.
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- W4300978877 cites W2050945292 @default.
- W4300978877 cites W2068767807 @default.
- W4300978877 cites W2097120541 @default.
- W4300978877 cites W2102619694 @default.
- W4300978877 cites W2103992875 @default.
- W4300978877 cites W2112017019 @default.
- W4300978877 cites W2118071133 @default.
- W4300978877 cites W2119451273 @default.
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- W4300978877 cites W2156683768 @default.
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- W4300978877 cites W2702680930 @default.
- W4300978877 cites W2726594986 @default.
- W4300978877 cites W2738563754 @default.
- W4300978877 cites W2750318914 @default.
- W4300978877 cites W2751575015 @default.
- W4300978877 cites W2754045890 @default.
- W4300978877 cites W2771542157 @default.
- W4300978877 cites W2774087343 @default.
- W4300978877 cites W2777333782 @default.
- W4300978877 cites W2792153970 @default.
- W4300978877 cites W2793601014 @default.
- W4300978877 cites W2794480084 @default.
- W4300978877 cites W2799739256 @default.
- W4300978877 cites W2802963454 @default.
- W4300978877 cites W2804600261 @default.
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- W4300978877 cites W2902229746 @default.
- W4300978877 cites W2903339613 @default.
- W4300978877 cites W2934396339 @default.
- W4300978877 cites W2948260295 @default.
- W4300978877 cites W2949177718 @default.
- W4300978877 cites W2952100718 @default.
- W4300978877 cites W2952343320 @default.
- W4300978877 cites W2984472267 @default.
- W4300978877 cites W2989897360 @default.
- W4300978877 cites W2992586616 @default.
- W4300978877 cites W3023126733 @default.
- W4300978877 cites W3045237069 @default.
- W4300978877 cites W3081969726 @default.
- W4300978877 cites W3086206613 @default.
- W4300978877 cites W3112137768 @default.
- W4300978877 cites W3122155574 @default.
- W4300978877 cites W3128250744 @default.
- W4300978877 cites W3137366663 @default.
- W4300978877 cites W3143387950 @default.
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- W4300978877 doi "https://doi.org/10.1016/j.celrep.2022.111455" @default.
- W4300978877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36198269" @default.
- W4300978877 hasPublicationYear "2022" @default.
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