FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4300978932> ?p ?o ?g. }

• W4300978932 endingPage "1202" @default.
• W4300978932 startingPage "1190" @default.
• W4300978932 abstract "The Nod-like receptor (NLR) family CARD domain containing 5 (NLRC5) has been reported as an activator of human leukocyte antigen (HLA) class I that is responsible for immune activity in cancer treatment. This work focuses on the role of BMI1 proto-oncogene (BMI1) in the NLRC5-HLA class I axis and in immune escape in non-small cell lung cancer (NSCLC). First, immunoblot analysis and/or reverse transcription-quantitative polymerase chain reaction were performed, which identified decreased NLRC5 and HLA class I levels in NSCLC tissues and cell lines. NSCLCs were co-cultured with activated CD8+ T cells. Overexpression of NLRC5 in NSCLC cells elevated the expression of HLA class I and increased the activity of T cells and IL-2 production, and it reduced the PD-1/PD-L1 levels. The ubiquitination and immunoprecipitation assays confirmed that BMI1 bound to NLRC5 to induce is ubiquitination and protein degradation. Downregulation of BMI1 in NSCLC cells elevated NLRC5 and HLA class I levels, and consequently promoted T cell activation and decreased PD-1/PD-L1 levels in the co-culture system. However, overexpression of BMI1 in cells led to inverse trends. In summary, this study demonstrates that BMI1 induces ubiquitination and protein degradation of NLRC5 and suppresses HLA class I expression, which potentially helps immune escape in NSCLC." @default.
• W4300978932 created "2022-10-04" @default.
• W4300978932 creator A5016099349 @default.
• W4300978932 creator A5022516246 @default.
• W4300978932 creator A5034370014 @default.
• W4300978932 creator A5043483203 @default.
• W4300978932 creator A5055175285 @default.
• W4300978932 creator A5087453755 @default.
• W4300978932 creator A5091806674 @default.
• W4300978932 date "2022-10-04" @default.
• W4300978932 modified "2023-10-01" @default.
• W4300978932 title "BMI1 induces ubiquitination and protein degradation of Nod‐like receptor family CARD domain containing 5 and suppresses human leukocyte antigen class I expression to induce immune escape in non‐small cell lung cancer" @default.
• W4300978932 cites W1149337507 @default.
• W4300978932 cites W1971272503 @default.
• W4300978932 cites W2017075227 @default.
• W4300978932 cites W2023291165 @default.
• W4300978932 cites W2035109715 @default.
• W4300978932 cites W2038032899 @default.
• W4300978932 cites W2045174330 @default.
• W4300978932 cites W2053847949 @default.
• W4300978932 cites W2370999228 @default.
• W4300978932 cites W2541516234 @default.
• W4300978932 cites W2557697459 @default.
• W4300978932 cites W2699127236 @default.
• W4300978932 cites W2784371446 @default.
• W4300978932 cites W2801082810 @default.
• W4300978932 cites W2893318139 @default.
• W4300978932 cites W2907260420 @default.
• W4300978932 cites W2964471257 @default.
• W4300978932 cites W2967202427 @default.
• W4300978932 cites W2999405370 @default.
• W4300978932 cites W3017006437 @default.
• W4300978932 cites W3017307259 @default.
• W4300978932 cites W3020956173 @default.
• W4300978932 cites W3034929695 @default.
• W4300978932 cites W3044095240 @default.
• W4300978932 cites W3091696541 @default.
• W4300978932 cites W3107452708 @default.
• W4300978932 cites W3124715390 @default.
• W4300978932 cites W3128646645 @default.
• W4300978932 cites W4220694031 @default.
• W4300978932 doi "https://doi.org/10.1002/kjm2.12602" @default.
• W4300978932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36194200" @default.
• W4300978932 hasPublicationYear "2022" @default.
• W4300978932 type Work @default.
• W4300978932 citedByCount "1" @default.
• W4300978932 countsByYear W43009789322023 @default.
• W4300978932 crossrefType "journal-article" @default.
• W4300978932 hasAuthorship W4300978932A5016099349 @default.
• W4300978932 hasAuthorship W4300978932A5022516246 @default.
• W4300978932 hasAuthorship W4300978932A5034370014 @default.
• W4300978932 hasAuthorship W4300978932A5043483203 @default.
• W4300978932 hasAuthorship W4300978932A5055175285 @default.
• W4300978932 hasAuthorship W4300978932A5087453755 @default.
• W4300978932 hasAuthorship W4300978932A5091806674 @default.
• W4300978932 hasBestOaLocation W43009789321 @default.
• W4300978932 hasConcept C104317684 @default.
• W4300978932 hasConcept C127561419 @default.
• W4300978932 hasConcept C147483822 @default.
• W4300978932 hasConcept C153911025 @default.
• W4300978932 hasConcept C167672396 @default.
• W4300978932 hasConcept C188280979 @default.
• W4300978932 hasConcept C203014093 @default.
• W4300978932 hasConcept C25602115 @default.
• W4300978932 hasConcept C502942594 @default.
• W4300978932 hasConcept C55493867 @default.
• W4300978932 hasConcept C71924100 @default.
• W4300978932 hasConcept C86803240 @default.
• W4300978932 hasConcept C8891405 @default.
• W4300978932 hasConceptScore W4300978932C104317684 @default.
• W4300978932 hasConceptScore W4300978932C127561419 @default.
• W4300978932 hasConceptScore W4300978932C147483822 @default.
• W4300978932 hasConceptScore W4300978932C153911025 @default.
• W4300978932 hasConceptScore W4300978932C167672396 @default.
• W4300978932 hasConceptScore W4300978932C188280979 @default.
• W4300978932 hasConceptScore W4300978932C203014093 @default.
• W4300978932 hasConceptScore W4300978932C25602115 @default.
• W4300978932 hasConceptScore W4300978932C502942594 @default.
• W4300978932 hasConceptScore W4300978932C55493867 @default.
• W4300978932 hasConceptScore W4300978932C71924100 @default.
• W4300978932 hasConceptScore W4300978932C86803240 @default.
• W4300978932 hasConceptScore W4300978932C8891405 @default.
• W4300978932 hasIssue "12" @default.
• W4300978932 hasLocation W43009789321 @default.
• W4300978932 hasLocation W43009789322 @default.
• W4300978932 hasLocation W43009789323 @default.
• W4300978932 hasOpenAccess W4300978932 @default.
• W4300978932 hasPrimaryLocation W43009789321 @default.
• W4300978932 hasRelatedWork W1998441351 @default.
• W4300978932 hasRelatedWork W2065602427 @default.
• W4300978932 hasRelatedWork W2220102944 @default.
• W4300978932 hasRelatedWork W2409441623 @default.
• W4300978932 hasRelatedWork W2411621882 @default.
• W4300978932 hasRelatedWork W2423790058 @default.
• W4300978932 hasRelatedWork W2903752946 @default.
• W4300978932 hasRelatedWork W3042473936 @default.
• W4300978932 hasRelatedWork W4210976760 @default.
• W4300978932 hasRelatedWork W1926304844 @default.

• next