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- W4300981677 abstract "Abstract Cerebral inflammation with invasion of neutrophils and lymphocytes is a crucial factor in the process of secondary brain damage after traumatic brain injury (TBI). In TBI the intrinsic renin-angiotensin system is an important mediator of cerebral inflammation, as inhibition of the angiotensin II receptor type 1 (AT1) reduces secondary brain damage and the invasion of neutrophil granulocytes into injured cerebral tissue. The present study investigated the role of immune cells in AT1 inhibition-mediated neuroprotection after experimental TBI. In four different cohorts, male mice were studied to examine effects of neutropenia (anti-Ly6G antibody mediated neutrophil depletion; C57BL/6) or lymphopenia (RAG1 deficiency, RAG1 -/- ) alone, or in combination with candesartan-mediated AT1 inhibition. The present results demonstrate that reduction of neutrophils (neutrophil depletion in wild type mice) and of lymphocytes (RAG1 -/- ) as well as AT1 inhibition in (control antibody treated) wild type and RAG1 -/- mice reduce brain damage and neuroinflammation after TBI compared to control groups, while in neutropenic mice, candesartan had no effect. However, AT1 inhibition was neuroprotective in RAG1 -/- mice, but not in neutropenic mice. Therefore, the results indicate that AT1 inhibition mediated neuroprotection may be exerted by anti-inflammatory effects on neutrophils, with a subsequent reduction of neutrophil invasion." @default.
- W4300981677 created "2022-10-04" @default.
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- W4300981677 date "2022-10-04" @default.
- W4300981677 modified "2023-10-15" @default.
- W4300981677 title "AT 1 inhibition mediated neuroprotection after experimental traumatic brain injury is dependent on neutrophils in male mice" @default.
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- W4300981677 cites W1944546979 @default.
- W4300981677 cites W1984484733 @default.
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- W4300981677 cites W1990047789 @default.
- W4300981677 cites W1990514899 @default.
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- W4300981677 cites W1997603886 @default.
- W4300981677 cites W2001872567 @default.
- W4300981677 cites W2001921869 @default.
- W4300981677 cites W2004058094 @default.
- W4300981677 cites W2010915352 @default.
- W4300981677 cites W2012338377 @default.
- W4300981677 cites W2017581198 @default.
- W4300981677 cites W2021336399 @default.
- W4300981677 cites W2021345753 @default.
- W4300981677 cites W2025828188 @default.
- W4300981677 cites W2031706418 @default.
- W4300981677 cites W2033091119 @default.
- W4300981677 cites W2037190876 @default.
- W4300981677 cites W2040315363 @default.
- W4300981677 cites W2041082856 @default.
- W4300981677 cites W2042514203 @default.
- W4300981677 cites W2044527664 @default.
- W4300981677 cites W2055421409 @default.
- W4300981677 cites W2063731879 @default.
- W4300981677 cites W2064839996 @default.
- W4300981677 cites W2066442550 @default.
- W4300981677 cites W2072500831 @default.
- W4300981677 cites W2072846301 @default.
- W4300981677 cites W2073444107 @default.
- W4300981677 cites W2075782105 @default.
- W4300981677 cites W2076486455 @default.
- W4300981677 cites W2077224517 @default.
- W4300981677 cites W2077737136 @default.
- W4300981677 cites W2085925390 @default.
- W4300981677 cites W2087318599 @default.
- W4300981677 cites W2088230441 @default.
- W4300981677 cites W2095434115 @default.
- W4300981677 cites W2100115921 @default.
- W4300981677 cites W2100588727 @default.
- W4300981677 cites W2104246889 @default.
- W4300981677 cites W2116989971 @default.
- W4300981677 cites W2117736326 @default.
- W4300981677 cites W2117985944 @default.
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- W4300981677 cites W2128833728 @default.
- W4300981677 cites W2129783501 @default.
- W4300981677 cites W2131211125 @default.
- W4300981677 cites W2133402519 @default.
- W4300981677 cites W2137368645 @default.
- W4300981677 cites W2140090281 @default.
- W4300981677 cites W2140489687 @default.
- W4300981677 cites W2140500533 @default.
- W4300981677 cites W2141771317 @default.
- W4300981677 cites W2146152680 @default.
- W4300981677 cites W2147180300 @default.
- W4300981677 cites W2148739955 @default.
- W4300981677 cites W2153626991 @default.
- W4300981677 cites W2168322315 @default.
- W4300981677 cites W2169800603 @default.
- W4300981677 cites W2181484272 @default.
- W4300981677 cites W2317227939 @default.
- W4300981677 cites W2325990358 @default.
- W4300981677 cites W2559680470 @default.
- W4300981677 cites W2586825713 @default.
- W4300981677 cites W2623601580 @default.
- W4300981677 cites W2728496947 @default.
- W4300981677 cites W2788083970 @default.
- W4300981677 cites W2889566041 @default.
- W4300981677 cites W2941744067 @default.
- W4300981677 cites W2966464394 @default.
- W4300981677 cites W2999425498 @default.
- W4300981677 cites W3047109959 @default.
- W4300981677 cites W3137110784 @default.
- W4300981677 cites W4240172142 @default.
- W4300981677 cites W4292615851 @default.
- W4300981677 doi "https://doi.org/10.21203/rs.3.rs-2110098/v1" @default.
- W4300981677 hasPublicationYear "2022" @default.
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