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- W4301030180 abstract "Activated macrophages require L-arginine uptake to sustain NO synthesis. Several transport systems could mediate this L-arginine influx. Using competition analysis and gene-expression studies, amino acid transport system y+ was identified as the major carrier responsible for this activity. To identify which of the four known y+ transport-system genes is involved in macrophage-induced L-arginine uptake, we used a hybrid-depletion study in Xenopus oocytes. Cationic amino acid transporter (CAT) 2 antisense oligodeoxyribonucleotides abolished the activated-macrophage-mRNA-induced L-arginine transport. Together with expression studies documenting that CAT2 mRNA and protein levels are elevated with increased L-arginine uptake, our data demonstrate that CAT2 mediates the L-arginine transport that is required for the raised NO production in activated J774 macrophages." @default.
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- W4301030180 date "1999-05-25" @default.
- W4301030180 modified "2023-10-14" @default.
- W4301030180 title "CAT2-mediated l-arginine transport and nitric oxide production in activated macrophages" @default.
- W4301030180 doi "https://doi.org/10.1042/bj3400549" @default.
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