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- W4301107712 abstract "Carfilzomib is a selective proteasome inhibitor used for the treatment of multiple myeloma and mantle cell lymphoma. The metabolism of carfilzomib was examined in rats after intravenous administration. Metabolites in the plasma, urine, and bile samples were analyzed. Amide hydrolysis and the opening of the epoxide were the major metabolic pathways observed, which generated numerous metabolites. In addition, hydroxylation of the isobutyl group and the dehydrogenation of the morpholine ring were the minor metabolic pathways. Morpholino‐homophenylalanine, morpholino‐homophenylalanine‐leucine, and the diol of carfilzomib were the most abundant metabolites in both plasma and excreta." @default.
- W4301107712 created "2022-10-04" @default.
- W4301107712 creator A5041463594 @default.
- W4301107712 date "2013-10-13" @default.
- W4301107712 modified "2023-09-26" @default.
- W4301107712 title "Carfilzomib" @default.
- W4301107712 cites W2154326312 @default.
- W4301107712 doi "https://doi.org/10.1002/9781118541203.xen260" @default.
- W4301107712 hasPublicationYear "2013" @default.
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