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• W4301113265 abstract "No AccessJournal of UrologyInvestigative Urology1 Apr 19961,25-Dihydroxycholecalciferol Enhances the Expression of MHC Class II Antigens and Intercellular Adhesion Molecule-1 by Human Renal Tubular Epithelial Cells B. Kreft, S. Brzoska, C. Doehn, M.R. Daha, F.J. Van Der Woude, and K. Sack B. KreftB. Kreft More articles by this author , S. BrzoskaS. Brzoska More articles by this author , C. DoehnC. Doehn More articles by this author , M.R. DahaM.R. Daha More articles by this author , F.J. Van Der WoudeF.J. Van Der Woude More articles by this author , and K. SackK. Sack More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66305-5AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Beside its role in calcium and phosphorus metabolism, 1,25-dihydroxycholecalciferol (1,25-D3) exerts multiple effects on cytokine and major histocompatibility complex (MHC) class II expression in monocytes and lymphocytes. In different renal diseases tubular epithelial cells express MHC class II molecules and cell adhesion molecules, such as intercellular adhesion molecule-1 (ICAM-1). Therefore, modulation of MHC class II and ICAM-1 expression in renal tubular epithelial cells by 1,25-D3 may be relevant to lymphocyte adhesion to tubular epithelial cells and immune mediated renal injury. However, the expression of MHC class II antigens and cellular adhesion molecules by renal tubular epithelial cells in response to 1,25-D3 has not been investigated. Materials and Methods: We generated human renal tubular epithelial cells and SV40 transfected tubular epithelial cells to investigate immune modulation of 1,25-D3 on renal epithelial cells. Major histocompatibility complex class II molecules and ICAM-1 were detected by a specific enzyme linked immunoassay. Results: We found a dose-dependent increase of both constitutive and induced MHC class II and ICAM-1 expression in tubular epithelial cells stimulated with 1,25-D3. Dose-dependent stimulation of MHC class II and ICAM-1 expression was not restricted to primary human renal tubular epithelial cells but was also detected in SV40 transfected cells. Conclusions: Expression of MHC class II and ICAM-1 is crucial for antigen presentation by and lymphocyte adhesion to renal tubular epithelial cells. Modulatory effects of 1,25-D3 on immune accessory function of renal tubular epithelial cells may be of clinical significance in renal diseases. References 1 : Effects of 1,25(OH) sub 2 D sub 3 administration on bone in patients with renal failure. Kidney Int.1990; 38: 48. Google Scholar 2 : Regulation of human monocyte HLA-DR and CD4 antigen expression, and antigen presentation by 1,25-dihydroxyvitamin D3. Blood1990; 76: 189. Google Scholar 3 : 1 alpha, 25-dihydroxyvitamin D3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes. Proc. Natl. Acad. Sci. U.S.A.1987; 84: 3385. Google Scholar 4 : Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. J. Clin. Invest.1987; 79: 1659. Google Scholar 5 : Interferon-gamma-induced IA expression in Wehi-3 cells is enhanced by the presence of 1,25-dihydroxyvitamin D3. J. Immunol.1986; 136: 2181. Google Scholar 6 : Immunomodulatory role of 1,25-dihydroxyvitamin D3. J. Cell. 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Google Scholar 26 : 1 alpha, 25-dihydroxyvitamin D3 induces maturation of the human monocyte cell line U937 and in association with a factor from human T lymphocytes augments production of the monokine, mononuclear cell factor. J. Clin. Invest.1984; 73: 731. Google Scholar 27 : MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells. Kidney Int.1990; 37: 783. Google Scholar 28 : B7+-transfectant tubular epitheial cells induce T cell energy, ignorance or proliferation. Kidney Int.1994; 45: 1105. Google Scholar 29 : Regulation of the costimulator B7, not class II major histocompatibility complex, restricts the ability of murine kidney tubule cells to stimulate CD4+ T cells. J. Clin. Invest.1994; 93: 1208. Google Scholar 30 : Active hepatitis B vaccination of dialysis patients and medical staff. Kidney Int.1984; 25: 124. Google Scholar 31 : Impaired cellular immune responses in chronic renal failure: evidence for a T cell defect. Kidney Int.1986; 29: 1209. Google Scholar 32 : In vivo effect of 1,25-dihydroxyvitamin D3 on phagocyte function in hemodialysis patients. Kidney Int.1991; 40: 927. Google Scholar Departments of Internal Medicine and Urology, Medical University of Lubeck, Lubeck, Germany and the Department of Nephrology, Academisch Ziekenhuis Leiden, Leiden, The Netherlands© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 155Issue 4April 1996Page: 1448-1453 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information B. Kreft More articles by this author S. Brzoska More articles by this author C. Doehn More articles by this author M.R. Daha More articles by this author F.J. Van Der Woude More articles by this author K. Sack More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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