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- W4301163685 abstract "Recent data has implicated a role for the vestibular system in maintaining blood pressure and cerebral blood flow (CBF). Through off vertical axis rotation (OVAR), we activated the otolith organs in 21 healthy subjects to determine their effect on CBF. Subjects rotated off vertical at 20° to a constant velocity in darkness at three frequencies (0.03125, 0.125 and 0.5 Hz) and three head directions (yaw angle: 0°, 40° left/right). CBF (transcranial Doppler), blood pressure (Portapres), and end tidal CO2 (Puritan Bennet) were measured continuously. CBF exhibited sinusoidal patterns (±2.7% at 0.03125; ±4.3% at 0.125; ±0.4% at 0.5 Hz) as did blood pressure (±5.1 mmHg at 0.03125; ±3.2 mmHg at 0.125; ±7.9 mmHg at 0.5Hz) which occurred as a function of frequency. Changing fixed head direction resulted in a phase shift in the associated CBF signal, but had negligible effects on blood pressure. Data indicate that by changing otolith position by moving to a leftward or rightward yaw of 40°, similar phase shifts occurred in CBF. Since trunk position remained unchanged, these data suggest that oscillations in CBF associated with OVAR are primarily due to otolith stimulation. Work supported by NIH NIDCD and NASA." @default.
- W4301163685 created "2022-10-04" @default.
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- W4301163685 date "2011-04-01" @default.
- W4301163685 modified "2023-09-23" @default.
- W4301163685 title "Cerebral Blood Flow Regulation: Role of Otolith Inputs" @default.
- W4301163685 doi "https://doi.org/10.1096/fasebj.25.1_supplement.647.17" @default.
- W4301163685 hasPublicationYear "2011" @default.
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