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• W4301178738 abstract "Expression of the transcription factor interferon regulatory factor 4 (IRF4) is required for the development of lung conventional DCs type 2 (cDC2s) that elicit Th2 responses, yet how IRF4 functions in lung cDC2s throughout the acute and memory allergic response is not clear. Here, we used a mouse model that loses IRF4 expression after lung cDC2 development to demonstrate that mice with IRF4-deficient DCs display impaired memory responses to allergen. This defect in the memory response was a direct result of ineffective Th2 induction and impaired recruitment of activated effector T cells to the lung after sensitization. IRF4-deficient DCs demonstrated defects in their migration to the draining lymph node and in T cell priming. Finally, T cells primed by IRF4-competent DCs mediated potent memory responses independently of IRF4-expressing DCs, demonstrating that IRF4-expressing DCs are not necessary during the memory response. Thus, IRF4 controlled a program in mature DCs governing Th2 priming and effector responses, but IRF4-expressing DCs were dispensable during tissue-resident memory T cell-dependent memory responses." @default.
• W4301178738 created "2022-10-04" @default.
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• W4301178738 date "2022-11-08" @default.
• W4301178738 modified "2023-09-27" @default.
• W4301178738 title "IRF4 expression by lung dendritic cells drives acute but not Trm cell–dependent memory Th2 responses" @default.
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• W4301178738 doi "https://doi.org/10.1172/jci.insight.140384" @default.
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