FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4301179147> ?p ?o ?g. }

• W4301179147 abstract "Abstract In lung adenocarcinoma (LUAD), the appearance of morphologically diverse tumor regions, termed histological patterns, is closely associated with disease progression and lymph node metastasis. However, the molecular characteristics of the histological patterns in LUAD and the underlying molecular evolutionary mechanisms between the histological patterns in primary tumors and lymph node metastases are poorly understood. Here, we re‐analyzed the large TCGA‐LUAD dataset and depicted a comprehensive profiling of the genome and transcriptome across the histological patterns in LUAD. Tumor phylogenetic trajectory analysis suggested that the complex glands is more apt to metastasize to the lymph node. Further deconvolution of the tumor microenvironment demonstrated that the complex glands had a higher infiltration of cancer‐associated fibroblasts (CAFs). Single‐cell transcriptome profiling of complex glands pattern identified a novel CAF subtype co‐expressing fibroblast activation protein‐alpha (FAP) and stimulator of interferon genes (STING). Moreover, our data demonstrated that FAP is an important downstream effector of STING in CAFs. In summary, our results provide the basis for the development of innovative therapeutic guidelines and intervention strategies for LUAD patients." @default.
• W4301179147 created "2022-10-04" @default.
• W4301179147 creator A5003554902 @default.
• W4301179147 creator A5008176130 @default.
• W4301179147 creator A5031460559 @default.
• W4301179147 creator A5038055814 @default.
• W4301179147 creator A5052151397 @default.
• W4301179147 creator A5054037584 @default.
• W4301179147 creator A5057403645 @default.
• W4301179147 creator A5071037763 @default.
• W4301179147 creator A5081722152 @default.
• W4301179147 creator A5082226210 @default.
• W4301179147 creator A5087773227 @default.
• W4301179147 date "2022-10-17" @default.
• W4301179147 modified "2023-10-15" @default.
• W4301179147 title "Characterization of the evolution trajectory and immune profiling of new histologic patterns in lung adenocarcinoma" @default.
• W4301179147 cites W1914351667 @default.
• W4301179147 cites W1964818072 @default.
• W4301179147 cites W1984068087 @default.
• W4301179147 cites W2021341670 @default.
• W4301179147 cites W2036144830 @default.
• W4301179147 cites W2048005397 @default.
• W4301179147 cites W2048253455 @default.
• W4301179147 cites W2049397238 @default.
• W4301179147 cites W2078253053 @default.
• W4301179147 cites W2138601221 @default.
• W4301179147 cites W2139788242 @default.
• W4301179147 cites W2152061559 @default.
• W4301179147 cites W2168133698 @default.
• W4301179147 cites W2169456326 @default.
• W4301179147 cites W2171892226 @default.
• W4301179147 cites W2585248318 @default.
• W4301179147 cites W2971559821 @default.
• W4301179147 cites W2982479866 @default.
• W4301179147 cites W3005312895 @default.
• W4301179147 cites W3022968840 @default.
• W4301179147 cites W3035834839 @default.
• W4301179147 cites W3048243382 @default.
• W4301179147 cites W3157637864 @default.
• W4301179147 cites W3163457197 @default.
• W4301179147 cites W3164371814 @default.
• W4301179147 cites W4210360326 @default.
• W4301179147 cites W4213073516 @default.
• W4301179147 cites W4214558584 @default.
• W4301179147 doi "https://doi.org/10.1002/jgm.3455" @default.
• W4301179147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36194517" @default.
• W4301179147 hasPublicationYear "2022" @default.
• W4301179147 type Work @default.
• W4301179147 citedByCount "0" @default.
• W4301179147 crossrefType "journal-article" @default.
• W4301179147 hasAuthorship W4301179147A5003554902 @default.
• W4301179147 hasAuthorship W4301179147A5008176130 @default.
• W4301179147 hasAuthorship W4301179147A5031460559 @default.
• W4301179147 hasAuthorship W4301179147A5038055814 @default.
• W4301179147 hasAuthorship W4301179147A5052151397 @default.
• W4301179147 hasAuthorship W4301179147A5054037584 @default.
• W4301179147 hasAuthorship W4301179147A5057403645 @default.
• W4301179147 hasAuthorship W4301179147A5071037763 @default.
• W4301179147 hasAuthorship W4301179147A5081722152 @default.
• W4301179147 hasAuthorship W4301179147A5082226210 @default.
• W4301179147 hasAuthorship W4301179147A5087773227 @default.
• W4301179147 hasConcept C104317684 @default.
• W4301179147 hasConcept C121608353 @default.
• W4301179147 hasConcept C142724271 @default.
• W4301179147 hasConcept C150194340 @default.
• W4301179147 hasConcept C162317418 @default.
• W4301179147 hasConcept C18431079 @default.
• W4301179147 hasConcept C203014093 @default.
• W4301179147 hasConcept C2776107976 @default.
• W4301179147 hasConcept C2780849966 @default.
• W4301179147 hasConcept C2781182431 @default.
• W4301179147 hasConcept C3020616263 @default.
• W4301179147 hasConcept C502942594 @default.
• W4301179147 hasConcept C54355233 @default.
• W4301179147 hasConcept C55493867 @default.
• W4301179147 hasConcept C71924100 @default.
• W4301179147 hasConcept C86803240 @default.
• W4301179147 hasConceptScore W4301179147C104317684 @default.
• W4301179147 hasConceptScore W4301179147C121608353 @default.
• W4301179147 hasConceptScore W4301179147C142724271 @default.
• W4301179147 hasConceptScore W4301179147C150194340 @default.
• W4301179147 hasConceptScore W4301179147C162317418 @default.
• W4301179147 hasConceptScore W4301179147C18431079 @default.
• W4301179147 hasConceptScore W4301179147C203014093 @default.
• W4301179147 hasConceptScore W4301179147C2776107976 @default.
• W4301179147 hasConceptScore W4301179147C2780849966 @default.
• W4301179147 hasConceptScore W4301179147C2781182431 @default.
• W4301179147 hasConceptScore W4301179147C3020616263 @default.
• W4301179147 hasConceptScore W4301179147C502942594 @default.
• W4301179147 hasConceptScore W4301179147C54355233 @default.
• W4301179147 hasConceptScore W4301179147C55493867 @default.
• W4301179147 hasConceptScore W4301179147C71924100 @default.
• W4301179147 hasConceptScore W4301179147C86803240 @default.
• W4301179147 hasFunder F4320321001 @default.
• W4301179147 hasFunder F4320321885 @default.
• W4301179147 hasFunder F4320325338 @default.
• W4301179147 hasFunder F4320336569 @default.
• W4301179147 hasIssue "11" @default.
• W4301179147 hasLocation W43011791471 @default.
• W4301179147 hasLocation W43011791472 @default.

• next