Matches in SemOpenAlex for { <https://semopenalex.org/work/W4301179947> ?p ?o ?g. }
- W4301179947 abstract "A conserved intracellular allosteric binding site (IABS) has recently been identified at several G protein-coupled receptors (GPCRs). Ligands targeting the IABS, so-called intracellular allosteric antagonists, are highly promising compounds for pharmaceutical intervention and currently evaluated in several clinical trials. Beside co-crystal structures that laid the foundation for the structure-based development of intracellular allosteric GPCR antagonists, small molecule tools that enable an unambiguous identification and characterization of intracellular allosteric GPCR ligands are of utmost importance for drug discovery campaigns in this field. Herein, we discuss recent approaches that leverage cellular target engagement studies for the IABS and thus play a critical role in the evaluation of IABS-targeted ligands as potential therapeutic agents." @default.
- W4301179947 created "2022-10-04" @default.
- W4301179947 creator A5005295253 @default.
- W4301179947 creator A5009855516 @default.
- W4301179947 creator A5017278944 @default.
- W4301179947 creator A5030273262 @default.
- W4301179947 creator A5074554905 @default.
- W4301179947 date "2022-11-08" @default.
- W4301179947 modified "2023-10-13" @default.
- W4301179947 title "Small Molecule Tools to Study Cellular Target Engagement for the Intracellular Allosteric Binding Site of GPCRs" @default.
- W4301179947 cites W1488181101 @default.
- W4301179947 cites W1492380293 @default.
- W4301179947 cites W1550129999 @default.
- W4301179947 cites W1961451051 @default.
- W4301179947 cites W1970877840 @default.
- W4301179947 cites W1979337045 @default.
- W4301179947 cites W2032319774 @default.
- W4301179947 cites W2037716842 @default.
- W4301179947 cites W2045881750 @default.
- W4301179947 cites W2049253479 @default.
- W4301179947 cites W2055504331 @default.
- W4301179947 cites W2108416430 @default.
- W4301179947 cites W2313348667 @default.
- W4301179947 cites W2419420935 @default.
- W4301179947 cites W2558217333 @default.
- W4301179947 cites W2560644533 @default.
- W4301179947 cites W2560722699 @default.
- W4301179947 cites W2604930678 @default.
- W4301179947 cites W2748144823 @default.
- W4301179947 cites W2797401814 @default.
- W4301179947 cites W2894033170 @default.
- W4301179947 cites W2951676089 @default.
- W4301179947 cites W2969261818 @default.
- W4301179947 cites W2989822266 @default.
- W4301179947 cites W2991588537 @default.
- W4301179947 cites W2998069397 @default.
- W4301179947 cites W3002542796 @default.
- W4301179947 cites W3038311311 @default.
- W4301179947 cites W3046562742 @default.
- W4301179947 cites W3110230623 @default.
- W4301179947 cites W3117557114 @default.
- W4301179947 cites W3130378701 @default.
- W4301179947 cites W3169620674 @default.
- W4301179947 cites W4200153171 @default.
- W4301179947 cites W4205379795 @default.
- W4301179947 cites W4220994831 @default.
- W4301179947 cites W4229441147 @default.
- W4301179947 cites W4285590274 @default.
- W4301179947 cites W4301179947 @default.
- W4301179947 doi "https://doi.org/10.1002/chem.202202565" @default.
- W4301179947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36193681" @default.
- W4301179947 hasPublicationYear "2022" @default.
- W4301179947 type Work @default.
- W4301179947 citedByCount "3" @default.
- W4301179947 countsByYear W43011799472022 @default.
- W4301179947 countsByYear W43011799472023 @default.
- W4301179947 crossrefType "journal-article" @default.
- W4301179947 hasAuthorship W4301179947A5005295253 @default.
- W4301179947 hasAuthorship W4301179947A5009855516 @default.
- W4301179947 hasAuthorship W4301179947A5017278944 @default.
- W4301179947 hasAuthorship W4301179947A5030273262 @default.
- W4301179947 hasAuthorship W4301179947A5074554905 @default.
- W4301179947 hasConcept C135285700 @default.
- W4301179947 hasConcept C161624437 @default.
- W4301179947 hasConcept C166342909 @default.
- W4301179947 hasConcept C170493617 @default.
- W4301179947 hasConcept C185592680 @default.
- W4301179947 hasConcept C2776038425 @default.
- W4301179947 hasConcept C55493867 @default.
- W4301179947 hasConcept C70721500 @default.
- W4301179947 hasConcept C74187038 @default.
- W4301179947 hasConcept C79879829 @default.
- W4301179947 hasConcept C86803240 @default.
- W4301179947 hasConceptScore W4301179947C135285700 @default.
- W4301179947 hasConceptScore W4301179947C161624437 @default.
- W4301179947 hasConceptScore W4301179947C166342909 @default.
- W4301179947 hasConceptScore W4301179947C170493617 @default.
- W4301179947 hasConceptScore W4301179947C185592680 @default.
- W4301179947 hasConceptScore W4301179947C2776038425 @default.
- W4301179947 hasConceptScore W4301179947C55493867 @default.
- W4301179947 hasConceptScore W4301179947C70721500 @default.
- W4301179947 hasConceptScore W4301179947C74187038 @default.
- W4301179947 hasConceptScore W4301179947C79879829 @default.
- W4301179947 hasConceptScore W4301179947C86803240 @default.
- W4301179947 hasFunder F4320309608 @default.
- W4301179947 hasFunder F4320320879 @default.
- W4301179947 hasIssue "1" @default.
- W4301179947 hasLocation W43011799471 @default.
- W4301179947 hasLocation W43011799472 @default.
- W4301179947 hasOpenAccess W4301179947 @default.
- W4301179947 hasPrimaryLocation W43011799471 @default.
- W4301179947 hasRelatedWork W2528155086 @default.
- W4301179947 hasRelatedWork W2788707514 @default.
- W4301179947 hasRelatedWork W2788787642 @default.
- W4301179947 hasRelatedWork W2797401814 @default.
- W4301179947 hasRelatedWork W2802838651 @default.
- W4301179947 hasRelatedWork W2885109335 @default.
- W4301179947 hasRelatedWork W2975716827 @default.
- W4301179947 hasRelatedWork W3047080990 @default.
- W4301179947 hasRelatedWork W4285736861 @default.