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- W4301279945 abstract "Classical experiments<sup>1-3</sup>have suggested and more recent studies<sup>4,5</sup>by radioimmunoassay have confirmed that the secretion of parathyroid hormone (PTH) is controlled by the serum calcium. There is a proportional relationship between hormone secretion in vivo and the serum calcium with rapid changes in the circulating level of PTH being noted within minutes after alterations in extracellular ion concentration.<sup>6</sup>Hypermagnesemia will also suppress the release of hormone from the parathyroid glands.<sup>5</sup> Exception to such tightly controlled homeostatic regulation may be found in patients with primary hyperparathyroidism due to a parathyroid adenoma or diffuse hyperplasia. Chronic hypocalcemia of even mild degree will produce significant secondary hyperplasia of the parathyroid glands, which may occasionally become autonomous (tertiary hyperparathyroidism) in long-standing stimulation.<sup>7-9</sup>The development of autonomous hyperparathyroidism is suggested by the appearance of hypercalcemia during chronic renal disease or after transplantation of the kidneys and correction of renal" @default.
- W4301279945 created "2022-10-05" @default.
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- W4301279945 date "1969-10-01" @default.
- W4301279945 modified "2023-10-18" @default.
- W4301279945 title "In Vitro Studies of Normal and Abnormal Parathyroid Tissue" @default.
- W4301279945 doi "https://doi.org/10.1001/archinte.1969.00300200038007" @default.
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