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- W4301323786 abstract "The kidney serves many important functions within the body including maintaining homeostasis of electrolytes, excretion of waste products, stimulation of red blood cell formation, and contributing to vitamin D metabolism. The kidney is also a target for the toxic effects of a wide range of compounds including drugs (e.g. cisplatin, amphotericin B, cyclosporine), metals (e.g. mercury, lead, cadmium), agricultural chemicals (e.g. paraquat), halogenated solvents (e.g. chloroform, trichloroethylene), natural products (e.g. mycotoxins), anoxiants (e.g. carbon monoxide, cyanide), and many other compounds. The reasons for the kidney's susceptibility to the toxic effects of drug and non-drug chemicals are related closely to its normal kidney function. The kidney is a highly dynamic organ, receiving 20–25% of the cardiac output. Thus, chemicals that enter the blood are rapidly distributed to the kidney. As a result, the kidney often sees high concentrations of absorbed chemicals and/or their toxic metabolites." @default.
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- W4301323786 date "2009-01-01" @default.
- W4301323786 modified "2023-09-23" @default.
- W4301323786 title "Target Sites" @default.
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- W4301323786 doi "https://doi.org/10.1016/b978-0-12-373593-5.00053-7" @default.
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