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• W4301351710 abstract "No AccessJournal of UrologyClinical Urology: Original Article1 Jan 1996Determining the Origin of Hematuria by Immunocytochemical Staining of Erythrocytes in Urine for Tamm-Horsfall Protein Atsushi Fukuzaki, Hiroyuki Kaneto, Shigenori Ikeda, and Seiichi Orikasa Atsushi FukuzakiAtsushi Fukuzaki More articles by this author , Hiroyuki KanetoHiroyuki Kaneto More articles by this author , Shigenori IkedaShigenori Ikeda More articles by this author , and Seiichi OrikasaSeiichi Orikasa More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66606-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We analyzed the feasibility of immunocytochemical staining of urinary erythrocytes for Tamm-Horsfall protein to differentiate renal from nonrenal hematuria. Materials and Methods: Urine samples collected from 74 patients with hematuria were evaluated. Erythrocytes in urine were inspected morphologically and the same samples were immunocytochemically stained with antibody against human Tamm-Horsfall protein. Results: Erythrocytes in urine were clearly stained for Tamm-Horsfall protein in renal hematuria. Tamm-Horsfall protein immunocytochemistry was more consistent with clinical diagnosis than morphology. Conclusions: Immunocytochemical staining of urine erythrocytes for Tamm-Horsfall protein appears to be a reliable tool to differentiate renal from nonrenal hematuria. References 1 : The evaluation of microscopic hematuria: a population-based study. J. Urol.1987; 138: 1189. Link, Google Scholar 2 : The diagnosis of neoplasia in patients with asymptomatic microscopic hematuria: a decision analysis. J. Urol.1988; 139: 1002. Link, Google Scholar 3 : Hematuria: a simple method for identifying glomerular bleeding. Kidney Int.1982; 21: 105. Google Scholar 4 : Value of urinary erythrocyte morphology in assessment of symptomless microhaematuria. Lancet1989; 2: 1316. Google Scholar 5 : The analysis of erythrocyte morphologic characteristics in urine using a hematologic flow cytometer and microscopic methods. Amer. J. Clin. Path.1991; 95: 257. Google Scholar 6 : Effect of urine osmolality on urinary red cell morphology. Nephron1990; 55: 344. Google Scholar 7 : In vitro production of 'glomerular red cells': role of pH and osmolality. Nephron1990; 56: 13. Google Scholar 8 : Effect of urine chemistry on red cells. Nephron1991; 59: 328. Google Scholar 9 : Effects of normal and abnormal urine on red cell shape. Nephron1992; 60: 383. Google Scholar 10 : Tamm-Horsfall protein coating of free cells in urine. Amer. J. Kidney Dis.1987; 9: 44. Google Scholar 11 : Localizing the site of hematuria by immunocytochemical staining of erythrocytes in urine. Clin. Chem.1992; 38: 216. Google Scholar 12 : Pathophysiology of Tamm-Horsfall protein. Kidney Int.1979; 16: 279. Google Scholar 13 : Tamm-Horsfall protein--uromodulin (1950-1990). Kidney Int.1990; 37: 1395. Google Scholar 14 : Detection of glomerular bleeding by phase-contrast microscopy. Lancet1982; 1: 1432. Google Scholar Department of Urology, Tohoku University School of Medicine, Sendai, Japan.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 155Issue 1January 1996Page: 248-251 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Atsushi Fukuzaki More articles by this author Hiroyuki Kaneto More articles by this author Shigenori Ikeda More articles by this author Seiichi Orikasa More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W4301351710 title "Determining the Origin of Hematuria by Immunocytochemical Staining of Erythrocytes in Urine for Tamm-Horsfall Protein" @default.
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