Matches in SemOpenAlex for { <https://semopenalex.org/work/W4301353643> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4301353643 endingPage "5" @default.
- W4301353643 startingPage "960" @default.
- W4301353643 abstract "To evaluate a monthly 'pulse' of rifampicin plus pyrazinamide plus streptomycin in the continuation phase of a short-course antituberculosis regimen.Randomised controlled trial of two 7-month chemotherapy regimens.Inpatient chemotherapy and outpatient follow-up in Tanzania.Smear-positive pulmonary tuberculosis.All patients received streptomycin plus rifampicin plus isoniazid plus pyrazinamide daily for 6 weeks followed by isoniazid daily for 24 weeks; 50%, at random, received additional doses of rifampicin, pyrazinamide and streptomycin every 4 weeks in the continuation phase. Follow-up continued for 23 months after cessation of chemotherapy.Bacteriological failure rate at the end of chemotherapy and relapse rate after stopping.Of the 266 patients with fully sensitive strains before treatment there was one failure in each series during chemotherapy; after stopping, 5% of the 114 who received the supplement relapsed bacteriologically compared with 10% of the 113 who did not (95% CI for the difference -0.02% to + 11.3%). The results in the 37 patients with strains resistant to isoniazid pretreatment were not as good, but similar for the two regimens.This study was not large enough to demonstrate a significant reduction in the relapse rate from 10% to 5%. If such a reduction were confirmed in a larger study it would represent an important improvement in efficacy. further, in an outpatient setting, the additional monthly doses might improve attendance." @default.
- W4301353643 created "2022-10-05" @default.
- W4301353643 date "1996-08-01" @default.
- W4301353643 modified "2023-09-29" @default.
- W4301353643 title "A controlled trial of a 4-weekly supplement of rifampicin, pyrazinamide and streptomycin in the continuation phase of a 7-month daily chemotherapy regimen for pulmonary tuberculosis. Tanzania/British Medical Research Council Collaborative Investigation." @default.
- W4301353643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8823423" @default.
- W4301353643 hasPublicationYear "1996" @default.
- W4301353643 type Work @default.
- W4301353643 citedByCount "1" @default.
- W4301353643 countsByYear W43013536432021 @default.
- W4301353643 crossrefType "journal-article" @default.
- W4301353643 hasConcept C126322002 @default.
- W4301353643 hasConcept C141071460 @default.
- W4301353643 hasConcept C142724271 @default.
- W4301353643 hasConcept C2775843808 @default.
- W4301353643 hasConcept C2776694085 @default.
- W4301353643 hasConcept C2776967927 @default.
- W4301353643 hasConcept C2778336483 @default.
- W4301353643 hasConcept C2778607973 @default.
- W4301353643 hasConcept C2780459521 @default.
- W4301353643 hasConcept C2781069245 @default.
- W4301353643 hasConcept C2781413609 @default.
- W4301353643 hasConcept C501593827 @default.
- W4301353643 hasConcept C71924100 @default.
- W4301353643 hasConcept C86803240 @default.
- W4301353643 hasConcept C89423630 @default.
- W4301353643 hasConceptScore W4301353643C126322002 @default.
- W4301353643 hasConceptScore W4301353643C141071460 @default.
- W4301353643 hasConceptScore W4301353643C142724271 @default.
- W4301353643 hasConceptScore W4301353643C2775843808 @default.
- W4301353643 hasConceptScore W4301353643C2776694085 @default.
- W4301353643 hasConceptScore W4301353643C2776967927 @default.
- W4301353643 hasConceptScore W4301353643C2778336483 @default.
- W4301353643 hasConceptScore W4301353643C2778607973 @default.
- W4301353643 hasConceptScore W4301353643C2780459521 @default.
- W4301353643 hasConceptScore W4301353643C2781069245 @default.
- W4301353643 hasConceptScore W4301353643C2781413609 @default.
- W4301353643 hasConceptScore W4301353643C501593827 @default.
- W4301353643 hasConceptScore W4301353643C71924100 @default.
- W4301353643 hasConceptScore W4301353643C86803240 @default.
- W4301353643 hasConceptScore W4301353643C89423630 @default.
- W4301353643 hasIssue "8" @default.
- W4301353643 hasLocation W43013536431 @default.
- W4301353643 hasOpenAccess W4301353643 @default.
- W4301353643 hasPrimaryLocation W43013536431 @default.
- W4301353643 hasRelatedWork W190162899 @default.
- W4301353643 hasRelatedWork W1991957921 @default.
- W4301353643 hasRelatedWork W2295071362 @default.
- W4301353643 hasRelatedWork W2410002868 @default.
- W4301353643 hasRelatedWork W2415538921 @default.
- W4301353643 hasRelatedWork W4230321444 @default.
- W4301353643 hasRelatedWork W4237077453 @default.
- W4301353643 hasRelatedWork W4255508965 @default.
- W4301353643 hasRelatedWork W4290270388 @default.
- W4301353643 hasRelatedWork W4299784455 @default.
- W4301353643 hasVolume "86" @default.
- W4301353643 isParatext "false" @default.
- W4301353643 isRetracted "false" @default.
- W4301353643 workType "article" @default.