FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4301370470> ?p ?o ?g. }

• W4301370470 endingPage "134272" @default.
• W4301370470 startingPage "134272" @default.
• W4301370470 abstract "• Designing and synthesizing three pharmaceutical salts of enoxacin (EX). • Cocrystallization of enoxacin with hydroxybenzoic acids by CAHBs interactions. • Improving the solubility of enoxacin by forming pharmaceutical salts. • Avoiding hygroscopicity of enoxacin by forming pharmaceutical salts. • Antibacterial activities of pharmaceutical salts are higher than that of enoxacin. With our ongoing purpose to improve the solubility of enoxacin (EX) and avoid its hygroscopicity by forming pharmaceutical salts, three unreported pharmaceutical salts of EX with m-hydroxybenzoic acid ((HEX)·C 7 H 5 O 3 ·H 2 O, EX-MHBA) (1), protocatechuic acid ((HEX)·C 7 H 5 O 4 ·2H 2 O, EX-PCA) (2) and gallic acid ((HEX)·C 7 H 5 O 5 , EX-GLA) (3) have been designed and synthesized by using solution evaporation approach and the description of their structures has been provided. Crystal structure and theoretical calculation analysis show that all three pharmaceutical salts undergo proton transfer and held stable crystal structure via charge assisted hydrogen bond. The solubility analysis of EX-MHBA, EX-PCA and EX-GLA showed that their solubilities were significantly higher than those of pure EX. The reason may be that both EX and the three hydroxybenzoic acids depend on charge assisted hydrogen bond to form EX-MHBA, EX-PCA and EX-GLA pharmaceutical salts, which increase the solubility of EX by ionizing it from the neutral molecule to the ionic state. Meanwhile, the hygroscopicity of EX-MHBA, EX-PCA and EX-GLA pharmaceutical salts was markedly improved compared to pure EX. This may be due to the near saturation of hydrogen bonds between the carboxylic acid group of hydroxybenzoic acid and its neighboring groups, resulting in the carboxylic acid group of hydroxybenzoic acid may have difficulty binding to external water molecules. The success of this work suggests that it may provide an encouraging approach to improve the solubility of insoluble active pharmaceutical ingredients while avoiding their hygroscopicity. Further to this, it is surprising that the antibacterial activities in vitro of three pharmaceutical salts of EX are better than that of the EX." @default.
• W4301370470 created "2022-10-05" @default.
• W4301370470 creator A5019974153 @default.
• W4301370470 creator A5022691823 @default.
• W4301370470 creator A5032429935 @default.
• W4301370470 creator A5034423500 @default.
• W4301370470 creator A5040600930 @default.
• W4301370470 creator A5043034777 @default.
• W4301370470 creator A5051229707 @default.
• W4301370470 creator A5052943622 @default.
• W4301370470 creator A5085257824 @default.
• W4301370470 creator A5085915806 @default.
• W4301370470 date "2023-02-01" @default.
• W4301370470 modified "2023-10-16" @default.
• W4301370470 title "Improved solubility and hygroscopicity of enoxacin by pharmaceutical salts formation with hydroxybenzonic acids via charge assisted hydrogen bond" @default.
• W4301370470 cites W182601290 @default.
• W4301370470 cites W1905183855 @default.
• W4301370470 cites W1979109090 @default.
• W4301370470 cites W1981353105 @default.
• W4301370470 cites W1989792857 @default.
• W4301370470 cites W2003964439 @default.
• W4301370470 cites W2013176211 @default.
• W4301370470 cites W2013564410 @default.
• W4301370470 cites W2017883113 @default.
• W4301370470 cites W2034374699 @default.
• W4301370470 cites W2038413105 @default.
• W4301370470 cites W2046624244 @default.
• W4301370470 cites W2047091536 @default.
• W4301370470 cites W2054759209 @default.
• W4301370470 cites W2059205366 @default.
• W4301370470 cites W2065809333 @default.
• W4301370470 cites W2070705137 @default.
• W4301370470 cites W2074411126 @default.
• W4301370470 cites W2078119532 @default.
• W4301370470 cites W2079524879 @default.
• W4301370470 cites W2083086205 @default.
• W4301370470 cites W2088569754 @default.
• W4301370470 cites W2095059784 @default.
• W4301370470 cites W2114061231 @default.
• W4301370470 cites W2119060556 @default.
• W4301370470 cites W2132525235 @default.
• W4301370470 cites W2157050203 @default.
• W4301370470 cites W2161353584 @default.
• W4301370470 cites W2263298170 @default.
• W4301370470 cites W2282896843 @default.
• W4301370470 cites W2325749340 @default.
• W4301370470 cites W2330767818 @default.
• W4301370470 cites W2340150951 @default.
• W4301370470 cites W2493265196 @default.
• W4301370470 cites W2526222923 @default.
• W4301370470 cites W2546889799 @default.
• W4301370470 cites W2576456099 @default.
• W4301370470 cites W2745664088 @default.
• W4301370470 cites W2758388885 @default.
• W4301370470 cites W2766133912 @default.
• W4301370470 cites W2778736190 @default.
• W4301370470 cites W2789147936 @default.
• W4301370470 cites W2892039032 @default.
• W4301370470 cites W2902440871 @default.
• W4301370470 cites W2917564005 @default.
• W4301370470 cites W2964046088 @default.
• W4301370470 cites W2977572124 @default.
• W4301370470 cites W3038573350 @default.
• W4301370470 cites W3040063260 @default.
• W4301370470 cites W3080976752 @default.
• W4301370470 cites W3097624745 @default.
• W4301370470 cites W3131883349 @default.
• W4301370470 cites W4211126900 @default.
• W4301370470 doi "https://doi.org/10.1016/j.molstruc.2022.134272" @default.
• W4301370470 hasPublicationYear "2023" @default.
• W4301370470 type Work @default.
• W4301370470 citedByCount "3" @default.
• W4301370470 countsByYear W43013704702023 @default.
• W4301370470 crossrefType "journal-article" @default.
• W4301370470 hasAuthorship W4301370470A5019974153 @default.
• W4301370470 hasAuthorship W4301370470A5022691823 @default.
• W4301370470 hasAuthorship W4301370470A5032429935 @default.
• W4301370470 hasAuthorship W4301370470A5034423500 @default.
• W4301370470 hasAuthorship W4301370470A5040600930 @default.
• W4301370470 hasAuthorship W4301370470A5043034777 @default.
• W4301370470 hasAuthorship W4301370470A5051229707 @default.
• W4301370470 hasAuthorship W4301370470A5052943622 @default.
• W4301370470 hasAuthorship W4301370470A5085257824 @default.
• W4301370470 hasAuthorship W4301370470A5085915806 @default.
• W4301370470 hasConcept C112887158 @default.
• W4301370470 hasConcept C155574463 @default.
• W4301370470 hasConcept C178790620 @default.
• W4301370470 hasConcept C185592680 @default.
• W4301370470 hasConcept C21951064 @default.
• W4301370470 hasConcept C2776072828 @default.
• W4301370470 hasConcept C2778512257 @default.
• W4301370470 hasConcept C2778746504 @default.
• W4301370470 hasConcept C32909587 @default.
• W4301370470 hasConcept C501593827 @default.
• W4301370470 hasConcept C55493867 @default.
• W4301370470 hasConceptScore W4301370470C112887158 @default.
• W4301370470 hasConceptScore W4301370470C155574463 @default.
• W4301370470 hasConceptScore W4301370470C178790620 @default.

• next