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- W4301370591 abstract "Concerns about the long-term consequences of anaesthesia exposure before age 4 years were brought to the attention of researchers and clinicians by some notable retrospective studies, which reported learning and behavioural deficits in adolescence that were significantly correlated to early anaesthesia exposure. 1 Wilder RT Flick RP Sprung J et al. Early exposure to anesthesia and learning disabilities in a population-based birth cohort. Anesthesiology. 2009; 110: 796-804 Crossref PubMed Scopus (1138) Google Scholar , 2 Chemaly M El-Rajab MA Ziade FM Naja ZM Effect of one anesthetic exposure on long-term behavioral changes in children. J Clin Anesth. 2014; 26: 551-556 Crossref PubMed Scopus (16) Google Scholar These clinical findings instigated a large amount of preclinical work that has consistently provided converging evidence for learning deficiency due to early anaesthesia exposure in a dose-dependent and duration-dependent manner. 3 Amrock LG Starner ML Murphy KL Baxter MG Long-term effects of single or multiple neonatal sevoflurane exposures on rat hippocampal ultrastructure. Anesthesiology. 2015; 122: 87-95 Crossref PubMed Scopus (122) Google Scholar However, when attempts have been made to apply these results to prospective clinical studies, similar deficits are not reported, potentially due to a disjunction in methodological continuity." @default.
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- W4301370591 date "2023-01-01" @default.
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- W4301370591 title "Preclinical and clinical paediatric anaesthesia research" @default.
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- W4301370591 doi "https://doi.org/10.1016/s2352-4642(22)00271-1" @default.
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