Matches in SemOpenAlex for { <https://semopenalex.org/work/W4301372514> ?p ?o ?g. }
- W4301372514 abstract "Abstract Objective While ample evidence highlights that the ipsilesional corticospinal tract (CST) plays a crucial role in motor recovery after stroke, very few studies have assessed cortico-cortical motor connections with inconclusive results. Given their unique potential to serve as structural reserve enabling motor network reorganization, the question arises whether cortico-cortical connections may facilitate motor control depending on CST damage. Methods Diffusion spectrum imaging (DSI) and a novel compartmentwise analysis approach were used to quantify structural connectivity between bilateral cortical core motor regions in chronic stroke patients. Basal and complex motor control were differentially assessed. Results Both basal and complex motor performance were correlated with structural connectivity between bilateral premotor areas and ipsilesional primary motor cortex (M1) as well as interhemispheric M1-M1 connectivity. While complex motor skills depended on CST integrity, a strong association between M1-M1 connectivity and basal motor control was observed independent of CST integrity especially in patients who underwent substantial motor recovery. Harnessing the informational wealth of cortico-cortical connectivity facilitated the explanation of both basal and complex motor control. Interpretation We demonstrate for the first time that distinct aspects of cortical structural reserve enable basal and complex motor control after stroke. In particular, recovery of basal motor control is supported via an alternative route through contralesional M1 and non-crossing fibers of the contralesional CST. Our findings help to explain previous conflicting interpretations regarding a vicarious or maladaptive role of the contralesional M1 and highlight the potential of structural connectivity of the cortical motor network as a biomarker post-stroke." @default.
- W4301372514 created "2022-10-05" @default.
- W4301372514 creator A5009779588 @default.
- W4301372514 creator A5020368326 @default.
- W4301372514 creator A5031985321 @default.
- W4301372514 creator A5035266623 @default.
- W4301372514 creator A5058453821 @default.
- W4301372514 creator A5058685727 @default.
- W4301372514 creator A5073743584 @default.
- W4301372514 creator A5075153407 @default.
- W4301372514 creator A5082140726 @default.
- W4301372514 date "2022-10-04" @default.
- W4301372514 modified "2023-09-26" @default.
- W4301372514 title "Basal but not complex motor control relies on interhemispheric structural connectivity after stroke" @default.
- W4301372514 cites W1534964070 @default.
- W4301372514 cites W1967077913 @default.
- W4301372514 cites W1970928383 @default.
- W4301372514 cites W1978844490 @default.
- W4301372514 cites W2011077238 @default.
- W4301372514 cites W2013360825 @default.
- W4301372514 cites W2013988865 @default.
- W4301372514 cites W2027266940 @default.
- W4301372514 cites W2031592758 @default.
- W4301372514 cites W2056881813 @default.
- W4301372514 cites W2073633782 @default.
- W4301372514 cites W2073832262 @default.
- W4301372514 cites W2078377297 @default.
- W4301372514 cites W2080032473 @default.
- W4301372514 cites W2085126485 @default.
- W4301372514 cites W2085440246 @default.
- W4301372514 cites W2088849407 @default.
- W4301372514 cites W2096225153 @default.
- W4301372514 cites W2103088051 @default.
- W4301372514 cites W2110065044 @default.
- W4301372514 cites W2119432914 @default.
- W4301372514 cites W2126597767 @default.
- W4301372514 cites W2137704770 @default.
- W4301372514 cites W2138914519 @default.
- W4301372514 cites W2140111053 @default.
- W4301372514 cites W2141338501 @default.
- W4301372514 cites W2143701627 @default.
- W4301372514 cites W2146316243 @default.
- W4301372514 cites W2157507565 @default.
- W4301372514 cites W2167822639 @default.
- W4301372514 cites W2168598091 @default.
- W4301372514 cites W2281454498 @default.
- W4301372514 cites W2485218258 @default.
- W4301372514 cites W2591610468 @default.
- W4301372514 cites W2726468696 @default.
- W4301372514 cites W2735740554 @default.
- W4301372514 cites W2754365328 @default.
- W4301372514 cites W2756175540 @default.
- W4301372514 cites W2762945840 @default.
- W4301372514 cites W2803837136 @default.
- W4301372514 cites W2999703487 @default.
- W4301372514 cites W3156097126 @default.
- W4301372514 cites W3174100758 @default.
- W4301372514 cites W3192854425 @default.
- W4301372514 cites W3213141617 @default.
- W4301372514 cites W4200355439 @default.
- W4301372514 cites W4280562686 @default.
- W4301372514 cites W4309765415 @default.
- W4301372514 doi "https://doi.org/10.1101/2022.10.04.22280666" @default.
- W4301372514 hasPublicationYear "2022" @default.
- W4301372514 type Work @default.
- W4301372514 citedByCount "0" @default.
- W4301372514 crossrefType "posted-content" @default.
- W4301372514 hasAuthorship W4301372514A5009779588 @default.
- W4301372514 hasAuthorship W4301372514A5020368326 @default.
- W4301372514 hasAuthorship W4301372514A5031985321 @default.
- W4301372514 hasAuthorship W4301372514A5035266623 @default.
- W4301372514 hasAuthorship W4301372514A5058453821 @default.
- W4301372514 hasAuthorship W4301372514A5058685727 @default.
- W4301372514 hasAuthorship W4301372514A5073743584 @default.
- W4301372514 hasAuthorship W4301372514A5075153407 @default.
- W4301372514 hasAuthorship W4301372514A5082140726 @default.
- W4301372514 hasBestOaLocation W43013725141 @default.
- W4301372514 hasConcept C105702510 @default.
- W4301372514 hasConcept C126838900 @default.
- W4301372514 hasConcept C137813230 @default.
- W4301372514 hasConcept C140530291 @default.
- W4301372514 hasConcept C143409427 @default.
- W4301372514 hasConcept C149550507 @default.
- W4301372514 hasConcept C15744967 @default.
- W4301372514 hasConcept C169760540 @default.
- W4301372514 hasConcept C24998067 @default.
- W4301372514 hasConcept C2778373776 @default.
- W4301372514 hasConcept C2779226451 @default.
- W4301372514 hasConcept C2779534489 @default.
- W4301372514 hasConcept C2779779279 @default.
- W4301372514 hasConcept C2780307956 @default.
- W4301372514 hasConcept C2781300654 @default.
- W4301372514 hasConcept C47611674 @default.
- W4301372514 hasConcept C71924100 @default.
- W4301372514 hasConcept C99508421 @default.
- W4301372514 hasConceptScore W4301372514C105702510 @default.
- W4301372514 hasConceptScore W4301372514C126838900 @default.
- W4301372514 hasConceptScore W4301372514C137813230 @default.
- W4301372514 hasConceptScore W4301372514C140530291 @default.
- W4301372514 hasConceptScore W4301372514C143409427 @default.