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• W4301373766 abstract "Abstract A growing body of research associates the oral microbiome and oral cancer. Well-characterized clinical samples with outcome data are required to establish relevant associations between the microbiota and disease. The objective of this study was to characterize the community variations and the functional implications of the microbiome in low-grade oral epithelial dysplasia (OED) using 16S rRNA gene sequencing from annotated archival swabs in progressing (P) and non-progressing (NP) OED. We characterised the microbial community in 90 OED samples — 30 swabs from low-grade OED that progressed to cancer (cases) and 60 swabs from low-grade OED that did not progress after a minimum of 5 years of follow up (matched control subjects). Across all samples, the dominant phyla were Firmicutes , Proteobacteria , Actinobacteriota , Bacteriodota , and Fusobacteriota . At the genus-level, Streptococcus was the most abundant, followed by Haemophilus , Rothia , and Neisseria. There were small but significant differences between P and NP samples in terms of alpha diversity as well as beta diversity in conjunction with other clinical factors such as age and smoking status for both taxa and functional predictions. While there were no significantly differentially abundant taxa or predicted functions between all Ps and NPs, there were a few genera, amplicon sequence variants (ASVs) and predicted enzyme commission (EC) numbers that were identified as differentially abundant when samples were grouped broadly by the number of years between sampling and progression or in specific time to progression for Ps only. These preliminary findings indicate that oral swabs can generate high-quality next-generation sequencing data, and that these samples could impart information about a patient's risk of cancer progression from OED." @default.
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• W4301373766 date "2022-10-04" @default.
• W4301373766 modified "2023-10-18" @default.
• W4301373766 title "Exploring the microbiome of oral epithelial dysplasia as a predictor of malignant progression" @default.
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• W4301373766 doi "https://doi.org/10.21203/rs.3.rs-2129013/v1" @default.
• W4301373766 hasPublicationYear "2022" @default.
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