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- W4301385075 abstract "Ankylosing spondylitis (AS) is a chronic systemic auto-inflammatory disease that mainly affects sacroiliac joints and the axial skeleton. AS shows the highest genetic association to human leukocyte antigen B27 (HLA-B*27) among the SpA family of diseases. While this link has been discovered many decades ago, the etiopathology of AS and the pathogenic role of HLA-B*27 in disease development remain to be fully elucidated. Increasing evidence supports the hypothesis that HLA-B*27-dependent diseases, such as, have an underlying microbial pathogenesis. This chapter discusses the causal mechanisms underlying disease pathogenesis in animal models and patient studies including the role of pathobionts in contributing toward HLA-B*27-associated AS. The chapter further discusses the current therapeutic approaches and the various emerging approaches of therapeutic modalities including prebiotics/probiotics, diet, targeted antibiotics, and microbial metabolites. As our understanding of the complex host-microbe interactions in AS improves, this may spur the development of new therapeutic avenues for AS and other HLA-B*27-associated diseases using approaches that target gut microbiota composition and function." @default.
- W4301385075 created "2022-10-05" @default.
- W4301385075 creator A5011569029 @default.
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- W4301385075 creator A5072077564 @default.
- W4301385075 creator A5079523319 @default.
- W4301385075 date "2022-01-01" @default.
- W4301385075 modified "2023-10-18" @default.
- W4301385075 title "Microorganisms in the Pathogenesis and Management of Ankylosing Spondylitis" @default.
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