FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4301391411> ?p ?o ?g. }

• W4301391411 endingPage "196" @default.
• W4301391411 startingPage "187" @default.
• W4301391411 abstract "Investigating inconclusive cystic fibrosis (CF) diagnosis in children is difficult without advanced cystic fibrosis transmembrane conductance regulator (CFTR) function tests. This study investigated the utility of beta (β)-adrenergic sweat test to exclude CF in participants with inconclusive diagnosis (CF suspects) in South Africa.β-adrenergic sweat test and sweat chloride tests (SCT) were performed simultaneously in CF suspects and adult controls (healthy, CFTR heterozygotes and CF). Cholinergic and β-adrenergic induced sweat rate was measured by evaporimetry (transepithelial water loss [TEWL]: g H2 O/m2 /h) following intradermal injections. Next-generation sequencing of CFTR was performed in CF suspects. CF diagnosis was defined by genotype.Thirty-seven controls (10 healthy, 14 CF, 13 CFTR heterozygotes) and 32 CF suspects (26 children; 6 adults) were enrolled. Six were excluded from formal analyses due to β-adrenergic sweat test failure. In adults, evaporimetry was superior to SCT for diagnosis of CF with β-adrenergic:cholinergic ratio TEWL ≤ 0.05 achieving 100% sensitivity and specificity. Twenty-two CF suspect children (age range: 3.4-15.6 years) completed β-adrenergic sweat testing of which none had CF confirmed by genotyping: β-adrenergic:cholinergic ratio > 0.05 successfully excluded CF in all but one child who was CFTR heterozygous. Median peak β-adrenergic TEWL and β-adrenergic:cholinergic ratio in CFTR negative and CFTR heterozygous children was significantly lower than adult controls.β-adrenergic sweat test is more accurate than SCT for excluding CF in children with inconclusive diagnosis. Established reference ranges for β-adrenergic sweat test may not be suitable for children due to lower β-adrenergic sweat secretion compared to adults." @default.
• W4301391411 created "2022-10-05" @default.
• W4301391411 creator A5001166372 @default.
• W4301391411 creator A5002988667 @default.
• W4301391411 creator A5006452129 @default.
• W4301391411 creator A5069322818 @default.
• W4301391411 creator A5075177790 @default.
• W4301391411 creator A5083472606 @default.
• W4301391411 creator A5088680060 @default.
• W4301391411 date "2022-10-17" @default.
• W4301391411 modified "2023-10-17" @default.
• W4301391411 title "β‐adrenergic sweat test in children with inconclusive cystic fibrosis diagnosis: Do we need new reference ranges?" @default.
• W4301391411 cites W1549465790 @default.
• W4301391411 cites W1899606784 @default.
• W4301391411 cites W1988727792 @default.
• W4301391411 cites W2005141354 @default.
• W4301391411 cites W2009896141 @default.
• W4301391411 cites W2017334513 @default.
• W4301391411 cites W2046151987 @default.
• W4301391411 cites W2046544551 @default.
• W4301391411 cites W2054787887 @default.
• W4301391411 cites W2057737579 @default.
• W4301391411 cites W2093070333 @default.
• W4301391411 cites W2099449365 @default.
• W4301391411 cites W2108671316 @default.
• W4301391411 cites W2144939604 @default.
• W4301391411 cites W2148970730 @default.
• W4301391411 cites W2171326656 @default.
• W4301391411 cites W2176250529 @default.
• W4301391411 cites W2415894980 @default.
• W4301391411 cites W2519297834 @default.
• W4301391411 cites W2533377295 @default.
• W4301391411 cites W2582657518 @default.
• W4301391411 cites W2779535514 @default.
• W4301391411 cites W2796146297 @default.
• W4301391411 cites W2946903789 @default.
• W4301391411 cites W2963707897 @default.
• W4301391411 cites W3031889979 @default.
• W4301391411 cites W3045709118 @default.
• W4301391411 cites W3142186370 @default.
• W4301391411 cites W3209477824 @default.
• W4301391411 cites W4283778176 @default.
• W4301391411 cites W4301391411 @default.
• W4301391411 doi "https://doi.org/10.1002/ppul.26179" @default.
• W4301391411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36193559" @default.
• W4301391411 hasPublicationYear "2022" @default.
• W4301391411 type Work @default.
• W4301391411 citedByCount "2" @default.
• W4301391411 countsByYear W43013914112022 @default.
• W4301391411 countsByYear W43013914112023 @default.
• W4301391411 crossrefType "journal-article" @default.
• W4301391411 hasAuthorship W4301391411A5001166372 @default.
• W4301391411 hasAuthorship W4301391411A5002988667 @default.
• W4301391411 hasAuthorship W4301391411A5006452129 @default.
• W4301391411 hasAuthorship W4301391411A5069322818 @default.
• W4301391411 hasAuthorship W4301391411A5075177790 @default.
• W4301391411 hasAuthorship W4301391411A5083472606 @default.
• W4301391411 hasAuthorship W4301391411A5088680060 @default.
• W4301391411 hasBestOaLocation W43013914111 @default.
• W4301391411 hasConcept C104317684 @default.
• W4301391411 hasConcept C126322002 @default.
• W4301391411 hasConcept C134018914 @default.
• W4301391411 hasConcept C135763542 @default.
• W4301391411 hasConcept C153471976 @default.
• W4301391411 hasConcept C158453852 @default.
• W4301391411 hasConcept C170493617 @default.
• W4301391411 hasConcept C185592680 @default.
• W4301391411 hasConcept C187212893 @default.
• W4301391411 hasConcept C22885893 @default.
• W4301391411 hasConcept C2776169613 @default.
• W4301391411 hasConcept C2776938444 @default.
• W4301391411 hasConcept C2778428886 @default.
• W4301391411 hasConcept C2779879311 @default.
• W4301391411 hasConcept C55493867 @default.
• W4301391411 hasConcept C63398376 @default.
• W4301391411 hasConcept C71924100 @default.
• W4301391411 hasConceptScore W4301391411C104317684 @default.
• W4301391411 hasConceptScore W4301391411C126322002 @default.
• W4301391411 hasConceptScore W4301391411C134018914 @default.
• W4301391411 hasConceptScore W4301391411C135763542 @default.
• W4301391411 hasConceptScore W4301391411C153471976 @default.
• W4301391411 hasConceptScore W4301391411C158453852 @default.
• W4301391411 hasConceptScore W4301391411C170493617 @default.
• W4301391411 hasConceptScore W4301391411C185592680 @default.
• W4301391411 hasConceptScore W4301391411C187212893 @default.
• W4301391411 hasConceptScore W4301391411C22885893 @default.
• W4301391411 hasConceptScore W4301391411C2776169613 @default.
• W4301391411 hasConceptScore W4301391411C2776938444 @default.
• W4301391411 hasConceptScore W4301391411C2778428886 @default.
• W4301391411 hasConceptScore W4301391411C2779879311 @default.
• W4301391411 hasConceptScore W4301391411C55493867 @default.
• W4301391411 hasConceptScore W4301391411C63398376 @default.
• W4301391411 hasConceptScore W4301391411C71924100 @default.
• W4301391411 hasFunder F4320322697 @default.
• W4301391411 hasIssue "1" @default.
• W4301391411 hasLocation W43013914111 @default.
• W4301391411 hasLocation W43013914112 @default.
• W4301391411 hasLocation W43013914113 @default.

• next