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- W4301391505 abstract "Chemotherapy and targeted therapies are increasingly used as conventional means to control tumor growth and prolong survival. Patient treated with anti-neoplastic agents experience severe side effects, especially those cytotoxic chemotherapies. Exploring chemo agents with less side effects is the hot spot of anticancer research. In this study, three azaphilone derivatives (chaetoviridin A (1), chaetoviridin E (2) and chaetomugilin D (3)) were isolated from the endophyte of the plant Anoectochilus roxburghii (Wall.) Lindl, their structures were elucidated by NMR. The toxicity of these compounds was evaluated by zebrafish model. The results show that these compounds had no toxicity against zebrafish. These compounds may act as safe anticancer drug leads according to this result. These three azaphilone derivatives were first time reported isolated from Diaporthe species which mainly used to isolate from Chaetomium species." @default.
- W4301391505 created "2022-10-05" @default.
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- W4301391505 date "2022-11-01" @default.
- W4301391505 modified "2023-09-26" @default.
- W4301391505 title "Azaphilones from the Endophyte <i>Diaporthe</i> sp. and Their Toxicity" @default.
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- W4301391505 doi "https://doi.org/10.1002/cbdv.202200849" @default.
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- W4301391505 hasPublicationYear "2022" @default.
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