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• W4301393633 endingPage "2200169" @default.
• W4301393633 startingPage "2200169" @default.
• W4301393633 abstract "CD4+ T cells have the ability to differentiate into relatively specialized effector subsets after exposure to innate immune signals. The remarkable plasticity of CD4+ T cells is required to achieve immune responses in different tissues and against various pathogens. Numerous studies have shown that CD4+ T cells can play direct and indispensable roles in protective immunity by killing infected or transformed cells. Although the lineage decision of commitment to the CD4+ or CD8+ cell lineage is once thought to be inflexible, the identification of antigen-experienced CD4+ T cells with cytotoxic activity suggests the existence of unexpected plasticity for these cells. The recognition of CD4+ cytotoxic T lymphocytes (CTLs) and the mechanisms driving the differentiation of this particular cell subset create opportunities to explore the roles of these effector cells in protective immunity and immune-related pathology. CD4+ CTLs are proven to play a protective role in antiviral immunity. Here, the latest investigations on the phenotypic and functional features of CD4+ CTLs and their roles in antitumor immunity and immunotherapy are briefly reviewed." @default.
• W4301393633 created "2022-10-05" @default.
• W4301393633 creator A5035969098 @default.
• W4301393633 creator A5041586238 @default.
• W4301393633 creator A5041693797 @default.
• W4301393633 creator A5084190227 @default.
• W4301393633 date "2022-10-04" @default.
• W4301393633 modified "2023-10-16" @default.
• W4301393633 title "CD4⁺Cytotoxic T Lymphocytes in Cancer Immunity and Immunotherapy" @default.
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