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• W4301393959 abstract "Transient Receptor Potential Vanilloid subtype 3 (TRPV3) is a non-selective cation channel that is known to be activated by physiological temperature and endogenous ligands. Involvement of TRPV3 in different skin functions has been reported. In this work, we demonstrate that activation of TRPV3 by FPP, an endogenous ligand enhances skin wound healing and bacterial clearance there. We report for the first time that TRPV3 is endogenously expressed in macrophages and activation of TRPV3 results in efficient bacterial clearance. At the subcellular level, TRPV3 is present in the lysosome and also in the nucleolus. We demonstrate that pharmacological modulation of TRPV3 protects lysosomal functions at hyperthermic shock conditions. The localization of TRPV3 at the nucleolus is specific, more in case of LPS-treatment and dynamic with respect to the cell signalling. We demonstrate that at certain conditions, the nucleolar localization of TRPV3 is correlated with the presence of TRPV3 at the lysosome and with the cellular stress in general. We propose that TRPV3 act as a lysosomal regulator and sensor for cellular stress. These findings may have broad implications in understanding the cellular stress and TRPV3-induced channelopathies and may have clinical relevance to skin infection treatment." @default.
• W4301393959 created "2022-10-05" @default.
• W4301393959 creator A5046335864 @default.
• W4301393959 creator A5076791744 @default.
• W4301393959 date "2022-10-17" @default.
• W4301393959 modified "2023-10-02" @default.
• W4301393959 title "Presence of TRPV3 in macrophage lysosomes helps in skin wound healing against bacterial infection" @default.
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• W4301393959 doi "https://doi.org/10.1111/exd.14683" @default.
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