FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4301394489> ?p ?o ?g. }

• W4301394489 endingPage "124" @default.
• W4301394489 startingPage "114" @default.
• W4301394489 abstract "El envejecimiento cutáneo está influido por factores intrínsecos y extrínsecos y múltiples mecanismos patogénicos están involucrados. Los tratamientos utilizados en la actualidad son sobre todo tópicos o son procedimientos mínimamente invasivos. La evidencia sobre la utilidad de la terapia sistémica es limitada: los estudios son en su mayoría de pequeño tamaño, de reducida duración, incluyen a mujeres de manera mayoritaria, la metodología de evaluación es heterogénea y no hay parámetros consensuados de respuesta clínica relevante. Además, los suplementos o fármacos sistémicos no están exentos de efectos adversos. El colágeno hidrolizado oral y el ácido hialurónico oral son bien tolerados y múltiples ensayos clínicos muestran que pueden mitigar algunos signos de envejecimiento cutáneo. La isotretinoína oral en dosis bajas es otra alternativa, pero con un mayor potencial de efectos adversos. Múltiples suplementos, como vitaminas, flavonoides, diversos extractos de plantas y oligoelementos, presentan escasa evidencia clínica. El futuro del manejo del envejecimiento cutáneo parece ser el tratamiento con agentes senolíticos o senomórficos dirigidos específicamente contra células cutáneas senescentes. Skin aging is influenced by intrinsic and extrinsic factors and involves multiple pathogenic mechanisms. The most widely used treatments are topical products and minimally invasive procedures. Evidence on the benefits of systemic therapy is limited for several reasons: Reliance on mostly small and predominantly female samples, short study durations, methodologic heterogeneity, and a lack of consensus on which outcome measures are clinically relevant. Furthermore, systemic drugs and oral supplements are not without adverse effects. Oral hydrolyzed collagen and oral hyaluronic acid are well tolerated, and numerous clinical trials show they can mitigate some signs of skin aging. Low-dose oral isotretinoin is another option, but it has a higher risk of adverse effects. Evidence is lacking on the effects of the many dietary supplements on offer, such as vitamins, flavonoids, plant extracts, and trace elements. The future of skin aging management would appear to lie in the use of senolytic and senomorphic agents targeting senescent cells in the skin." @default.
• W4301394489 created "2022-10-05" @default.
• W4301394489 creator A5071512209 @default.
• W4301394489 creator A5072177946 @default.
• W4301394489 creator A5087058586 @default.
• W4301394489 creator A5088094210 @default.
• W4301394489 date "2023-02-01" @default.
• W4301394489 modified "2023-10-01" @default.
• W4301394489 title "Tratamiento mediante suplementación oral o fármacos sistémicos del envejecimiento cutáneo. Revisión narrativa de la literatura" @default.
• W4301394489 cites W1605808712 @default.
• W4301394489 cites W1941063112 @default.
• W4301394489 cites W1964531562 @default.
• W4301394489 cites W1983342608 @default.
• W4301394489 cites W1983463483 @default.
• W4301394489 cites W2007959672 @default.
• W4301394489 cites W2041855259 @default.
• W4301394489 cites W2044172090 @default.
• W4301394489 cites W2045777083 @default.
• W4301394489 cites W2046734535 @default.
• W4301394489 cites W2051683262 @default.
• W4301394489 cites W2054548124 @default.
• W4301394489 cites W2069761155 @default.
• W4301394489 cites W2071131165 @default.
• W4301394489 cites W2090812033 @default.
• W4301394489 cites W2095564683 @default.
• W4301394489 cites W2099588269 @default.
• W4301394489 cites W2111251075 @default.
• W4301394489 cites W2114154060 @default.
• W4301394489 cites W2118574581 @default.
• W4301394489 cites W2128481695 @default.
• W4301394489 cites W2141299709 @default.
• W4301394489 cites W2154256056 @default.
• W4301394489 cites W2164361361 @default.
• W4301394489 cites W2165087687 @default.
• W4301394489 cites W2179101856 @default.
• W4301394489 cites W2266290735 @default.
• W4301394489 cites W2298142647 @default.
• W4301394489 cites W2301467648 @default.
• W4301394489 cites W2301480332 @default.
• W4301394489 cites W2315987042 @default.
• W4301394489 cites W2416400601 @default.
• W4301394489 cites W2441720170 @default.
• W4301394489 cites W2514952012 @default.
• W4301394489 cites W2543395152 @default.
• W4301394489 cites W2588884768 @default.
• W4301394489 cites W2604215835 @default.
• W4301394489 cites W2605589947 @default.
• W4301394489 cites W2737218700 @default.
• W4301394489 cites W2743743650 @default.
• W4301394489 cites W2772006446 @default.
• W4301394489 cites W2779440595 @default.
• W4301394489 cites W2800438504 @default.
• W4301394489 cites W2810111102 @default.
• W4301394489 cites W2890640248 @default.
• W4301394489 cites W2891451861 @default.
• W4301394489 cites W2900333555 @default.
• W4301394489 cites W2911561197 @default.
• W4301394489 cites W2911722517 @default.
• W4301394489 cites W2913984865 @default.
• W4301394489 cites W2924987913 @default.
• W4301394489 cites W2947007611 @default.
• W4301394489 cites W2952611231 @default.
• W4301394489 cites W2978405780 @default.
• W4301394489 cites W2992445810 @default.
• W4301394489 cites W2998655168 @default.
• W4301394489 cites W3007017309 @default.
• W4301394489 cites W3018577707 @default.
• W4301394489 cites W3021230558 @default.
• W4301394489 cites W3029352171 @default.
• W4301394489 cites W3034562437 @default.
• W4301394489 cites W3036514486 @default.
• W4301394489 cites W3080098935 @default.
• W4301394489 cites W3096978488 @default.
• W4301394489 cites W3126817232 @default.
• W4301394489 cites W3133672570 @default.
• W4301394489 cites W3139113137 @default.
• W4301394489 cites W3139174543 @default.
• W4301394489 cites W3142518442 @default.
• W4301394489 cites W3149055924 @default.
• W4301394489 cites W3149672806 @default.
• W4301394489 cites W3155073573 @default.
• W4301394489 cites W3173479881 @default.
• W4301394489 cites W3188840863 @default.
• W4301394489 cites W3188944167 @default.
• W4301394489 cites W3198056423 @default.
• W4301394489 cites W3200709530 @default.
• W4301394489 cites W3201947370 @default.
• W4301394489 cites W3205113796 @default.
• W4301394489 cites W3215010548 @default.
• W4301394489 cites W4200116459 @default.
• W4301394489 cites W4207079517 @default.
• W4301394489 cites W4221020066 @default.
• W4301394489 cites W4225583300 @default.
• W4301394489 cites W4283259504 @default.
• W4301394489 cites W4283264158 @default.
• W4301394489 doi "https://doi.org/10.1016/j.ad.2022.09.014" @default.
• W4301394489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36206809" @default.
• W4301394489 hasPublicationYear "2023" @default.

• next