Matches in SemOpenAlex for { <https://semopenalex.org/work/W4301395274> ?p ?o ?g. }
- W4301395274 abstract "Abstract Antimicrobial peptides (AMPs) kill microbes or inhibit their growth and are promising next-generation antibiotics. Harnessing their full potential as antimicrobial agents will require methods for cost-effective large-scale production and purification. Here, we explore the possibility to exploit the high protein synthesis capacity of the chloroplast to produce AMPs in plants. Generating a large series of 29 sets of transplastomic tobacco plants expressing nine different AMPs as fusion proteins, we show that high-level constitutive AMP expression results in deleterious plant phenotypes. However, by utilizing inducible expression and fusions to the cleavable carrier protein SUMO, the cytotoxic effects of AMPs and fused AMPs are alleviated and plants with wild-type-like phenotypes are obtained. Importantly, purified AMP fusion proteins display antimicrobial activity independently of proteolytic removal of the carrier. Our work provides expression strategies for the synthesis of toxic polypeptides in chloroplasts, and establishes transplastomic plants as efficient production platform for antimicrobial peptides." @default.
- W4301395274 created "2022-10-05" @default.
- W4301395274 creator A5005731541 @default.
- W4301395274 creator A5014804872 @default.
- W4301395274 creator A5025931864 @default.
- W4301395274 creator A5032209024 @default.
- W4301395274 creator A5052632870 @default.
- W4301395274 creator A5060451936 @default.
- W4301395274 creator A5061029250 @default.
- W4301395274 creator A5064381189 @default.
- W4301395274 creator A5066414306 @default.
- W4301395274 creator A5073890345 @default.
- W4301395274 creator A5075199511 @default.
- W4301395274 date "2022-10-04" @default.
- W4301395274 modified "2023-10-06" @default.
- W4301395274 title "Expression strategies for the efficient synthesis of antimicrobial peptides in plastids" @default.
- W4301395274 cites W1502266823 @default.
- W4301395274 cites W1568454117 @default.
- W4301395274 cites W1666755687 @default.
- W4301395274 cites W1865774542 @default.
- W4301395274 cites W1916089144 @default.
- W4301395274 cites W1953843785 @default.
- W4301395274 cites W1967667739 @default.
- W4301395274 cites W1968112984 @default.
- W4301395274 cites W1974767167 @default.
- W4301395274 cites W1975085160 @default.
- W4301395274 cites W1976431857 @default.
- W4301395274 cites W1980441078 @default.
- W4301395274 cites W1980921491 @default.
- W4301395274 cites W1991843002 @default.
- W4301395274 cites W1991894394 @default.
- W4301395274 cites W1993287528 @default.
- W4301395274 cites W1997212522 @default.
- W4301395274 cites W2007527881 @default.
- W4301395274 cites W2008688295 @default.
- W4301395274 cites W2020719323 @default.
- W4301395274 cites W2024556021 @default.
- W4301395274 cites W2028740410 @default.
- W4301395274 cites W2029502441 @default.
- W4301395274 cites W2029862562 @default.
- W4301395274 cites W2030518320 @default.
- W4301395274 cites W2035411290 @default.
- W4301395274 cites W2035421428 @default.
- W4301395274 cites W2039252918 @default.
- W4301395274 cites W2039305280 @default.
- W4301395274 cites W2042702851 @default.
- W4301395274 cites W2042760907 @default.
- W4301395274 cites W2044397283 @default.
- W4301395274 cites W2053167380 @default.
- W4301395274 cites W2054602599 @default.
- W4301395274 cites W2055155126 @default.
- W4301395274 cites W2058277727 @default.
- W4301395274 cites W2060764828 @default.
- W4301395274 cites W2063951978 @default.
- W4301395274 cites W2073740018 @default.
- W4301395274 cites W2074419567 @default.
- W4301395274 cites W2078450961 @default.
- W4301395274 cites W2082844643 @default.
- W4301395274 cites W2084845164 @default.
- W4301395274 cites W2093062181 @default.
- W4301395274 cites W2094499798 @default.
- W4301395274 cites W2097099115 @default.
- W4301395274 cites W2098998842 @default.
- W4301395274 cites W2103318503 @default.
- W4301395274 cites W2105493445 @default.
- W4301395274 cites W2106535769 @default.
- W4301395274 cites W2108305786 @default.
- W4301395274 cites W2108606795 @default.
- W4301395274 cites W2109729481 @default.
- W4301395274 cites W2110862837 @default.
- W4301395274 cites W2130441475 @default.
- W4301395274 cites W2136144179 @default.
- W4301395274 cites W2137794666 @default.
- W4301395274 cites W2139775324 @default.
- W4301395274 cites W2142943312 @default.
- W4301395274 cites W2144462913 @default.
- W4301395274 cites W2148188777 @default.
- W4301395274 cites W2148693751 @default.
- W4301395274 cites W2149794110 @default.
- W4301395274 cites W2152254280 @default.
- W4301395274 cites W2152962828 @default.
- W4301395274 cites W2158299121 @default.
- W4301395274 cites W2167330543 @default.
- W4301395274 cites W2175270296 @default.
- W4301395274 cites W2257974587 @default.
- W4301395274 cites W2288792204 @default.
- W4301395274 cites W2314450753 @default.
- W4301395274 cites W2412920431 @default.
- W4301395274 cites W2519381787 @default.
- W4301395274 cites W2553877266 @default.
- W4301395274 cites W2762684645 @default.
- W4301395274 cites W2765794861 @default.
- W4301395274 cites W2781638931 @default.
- W4301395274 cites W2794977413 @default.
- W4301395274 cites W2807288187 @default.
- W4301395274 cites W2886561057 @default.
- W4301395274 cites W2941559899 @default.
- W4301395274 cites W2963902855 @default.
- W4301395274 cites W2981752404 @default.
- W4301395274 cites W2993577931 @default.