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- W4301395761 abstract "<ns4:p><ns4:bold>Background:</ns4:bold> Antimicrobial drug resistance is of great concern today. Infections by the antimicrobial resistant strains of <ns4:italic>Escherichia coli</ns4:italic>, including enteropathogenic as well as enterotoxigenic strains have been reported as a major cause of deaths, especially among young children in low- and middle-income countries. This has been augmented by antimicrobial misuse, over the counter availability and poor sanitation especially in low income areas.</ns4:p><ns4:p> This study aimed at characterizing antimicrobial resistant strains of <ns4:italic>Escherichia coli</ns4:italic> isolated from sanitation environments of the Majengo slum in Meru County, Kenya</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>: A cross-sectional study was conducted on 61 samples from soil, water and drains swabs. These were tested against five antimicrobial drugs by the Kirby disk diffusion method.</ns4:p><ns4:p> <ns4:bold>Results: </ns4:bold>A total of 42 (69%) of the samples had <ns4:italic>Escherichia coli. </ns4:italic>These recorded antimicrobial drug susceptibility as follows: Out of the five antimicrobial agents used, ceftazidime 28 (66.67%) showed the highest sensitivity followed by ciprofloxacin 26 (61.90%) and imepenem 25 (59.52%) respectively. cefotaxime and cefoxitin showed least sensitivity at 14 (33.33%) and 13 (30.95%) respectively. In intermediate imepenem and ciprofloxacin were the highest with 12 (28.57%) followed by cefotaxime 10 (23.81%). The least intermediate was observed in ceftazidime and cefoxitin both at 7 (16.67%). The highest resistance was observed in cefoxitin 22 (52.38%), followed by cefotaxime at 18 (42.86%). Ciprofloxacin, imepenem and ceftazidime had the lowest resistance 4 (9.52%), 5 (11.91%) and 7 (16.67%) respectively. The p-value <0.05 was considered significant to the study. </ns4:p><ns4:p> <ns4:bold>Conclusions:</ns4:bold> This study showed that <ns4:italic>Escherichia coli</ns4:italic> isolated from Majengo is pathogenic and resistant to antibiotics. Detection of <ns4:italic>Escherichia coli</ns4:italic> poses a great risk in the spread of resistant strains in human. Proper sanitation and hygiene awareness practices should be provided through education to the residents of this area.</ns4:p>" @default.
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- W4301395761 date "2022-10-04" @default.
- W4301395761 modified "2023-10-18" @default.
- W4301395761 title "Evaluation of antimicrobial susceptibility of Escherichia coli isolated from contaminated areas of Majengo slum in Meru County, Kenya" @default.
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- W4301395761 doi "https://doi.org/10.12688/f1000research.124121.1" @default.
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