Matches in SemOpenAlex for { <https://semopenalex.org/work/W4301396544> ?p ?o ?g. }
- W4301396544 abstract "Abstract TAPL is a lysosomal ATP-binding cassette transporter that translocates a broad spectrum of polypeptides from the cytoplasm into the lysosomal lumen. Here we report that, in addition to its well-known role as a peptide translocator, TAPL exhibits an ATP-dependent phosphatidylserine floppase activity that is the possible cause of its high basal ATPase activity and of the lack of coupling between ATP hydrolysis and peptide efflux. We also present the cryo-EM structures of mouse TAPL complexed with (i) phospholipid, (ii) cholesteryl hemisuccinate (CHS) and 9-mer peptide, and (iii) ADP·BeF 3 . The inward-facing structure reveals that F449 protrudes into the cylindrical transport pathway and divides it into a large hydrophilic central cavity and a sizable hydrophobic upper cavity. In the structure, the peptide binds to TAPL in horizontally-stretched fashion within the central cavity, while lipid molecules plug vertically into the upper cavity. Together, our results suggest that TAPL uses different mechanisms to function as a peptide translocase and a phosphatidylserine floppase." @default.
- W4301396544 created "2022-10-05" @default.
- W4301396544 creator A5017313796 @default.
- W4301396544 creator A5026612909 @default.
- W4301396544 creator A5037497178 @default.
- W4301396544 creator A5040142489 @default.
- W4301396544 creator A5046464106 @default.
- W4301396544 creator A5051572707 @default.
- W4301396544 creator A5063436585 @default.
- W4301396544 creator A5076535725 @default.
- W4301396544 creator A5088628057 @default.
- W4301396544 date "2022-10-04" @default.
- W4301396544 modified "2023-10-16" @default.
- W4301396544 title "The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase" @default.
- W4301396544 cites W1502594197 @default.
- W4301396544 cites W1586608290 @default.
- W4301396544 cites W1821679912 @default.
- W4301396544 cites W1912752546 @default.
- W4301396544 cites W1943327251 @default.
- W4301396544 cites W1964828092 @default.
- W4301396544 cites W1968347293 @default.
- W4301396544 cites W1968646181 @default.
- W4301396544 cites W1983518163 @default.
- W4301396544 cites W1983738750 @default.
- W4301396544 cites W1987579083 @default.
- W4301396544 cites W1997096528 @default.
- W4301396544 cites W1998903417 @default.
- W4301396544 cites W2000151821 @default.
- W4301396544 cites W2005574282 @default.
- W4301396544 cites W2009217111 @default.
- W4301396544 cites W2019582266 @default.
- W4301396544 cites W2021882008 @default.
- W4301396544 cites W2022242801 @default.
- W4301396544 cites W2022898783 @default.
- W4301396544 cites W2029459862 @default.
- W4301396544 cites W2031487956 @default.
- W4301396544 cites W2032592226 @default.
- W4301396544 cites W2043151506 @default.
- W4301396544 cites W2048457947 @default.
- W4301396544 cites W2048481354 @default.
- W4301396544 cites W2051896494 @default.
- W4301396544 cites W2058460324 @default.
- W4301396544 cites W2064675349 @default.
- W4301396544 cites W2067306364 @default.
- W4301396544 cites W2067661858 @default.
- W4301396544 cites W2069331019 @default.
- W4301396544 cites W2071692669 @default.
- W4301396544 cites W2074816193 @default.
- W4301396544 cites W2075305548 @default.
- W4301396544 cites W2076236539 @default.
- W4301396544 cites W2076988559 @default.
- W4301396544 cites W2079546337 @default.
- W4301396544 cites W2082064626 @default.
- W4301396544 cites W2090841445 @default.
- W4301396544 cites W2093507535 @default.
- W4301396544 cites W2108007504 @default.
- W4301396544 cites W2117429193 @default.
- W4301396544 cites W2119468178 @default.
- W4301396544 cites W2124026197 @default.
- W4301396544 cites W2132629607 @default.
- W4301396544 cites W2139004599 @default.
- W4301396544 cites W2154714625 @default.
- W4301396544 cites W2160961957 @default.
- W4301396544 cites W2162085554 @default.
- W4301396544 cites W2162097287 @default.
- W4301396544 cites W2163258998 @default.
- W4301396544 cites W2164169021 @default.
- W4301396544 cites W2166422114 @default.
- W4301396544 cites W2170193467 @default.
- W4301396544 cites W2170963314 @default.
- W4301396544 cites W2180229411 @default.
- W4301396544 cites W2271635813 @default.
- W4301396544 cites W2278419621 @default.
- W4301396544 cites W2336955671 @default.
- W4301396544 cites W2408873636 @default.
- W4301396544 cites W2560111401 @default.
- W4301396544 cites W2570779740 @default.
- W4301396544 cites W2587625522 @default.
- W4301396544 cites W2589923912 @default.
- W4301396544 cites W2593511418 @default.
- W4301396544 cites W2619656708 @default.
- W4301396544 cites W2770566660 @default.
- W4301396544 cites W2777467795 @default.
- W4301396544 cites W2784697242 @default.
- W4301396544 cites W2788735115 @default.
- W4301396544 cites W2897297857 @default.
- W4301396544 cites W2899714098 @default.
- W4301396544 cites W2900297013 @default.
- W4301396544 cites W2920861231 @default.
- W4301396544 cites W2942754201 @default.
- W4301396544 cites W2953320394 @default.
- W4301396544 cites W2957093526 @default.
- W4301396544 cites W2968765385 @default.
- W4301396544 cites W2972952625 @default.
- W4301396544 cites W3036186038 @default.
- W4301396544 cites W3083406432 @default.
- W4301396544 cites W3093209072 @default.
- W4301396544 cites W3108495343 @default.
- W4301396544 cites W3186311016 @default.
- W4301396544 cites W3208294991 @default.