FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4301397767> ?p ?o ?g. }

• W4301397767 abstract "Baihu-Guizhi decoction (BHGZD) is a well-documented traditional Chinese Medicine (TCM) prescription that has been extensively applied to treating rheumatoid arthritis. Despite of its beneficial outcomes, the chemical constituents of BHGZD have not been fully portrayed and the in vivo absorption, distribution, metabolism, and excretion (ADME) patterns of absorbed components have never been described.Characterization of absorbed components and in vivo biotransformation profiling of these feature compounds were based on the ultra-fast liquid chromatography-quadrupole-time-of-flight tandem mass spectrometry (UFLC-Q-TOF-MS/MS). Furthermore, the ultra-high-performance liquid chromatography tandem ion trap quadrupole mass spectrometry (UHPLC-Q-TRAP-MS/MS) system were performed to investigate the pharmacokinetics of active ingredients from BHGZD.In this study, we have identified and tentatively characterized 18 feature absorbed prototype and 15 metabolites of BHGZD in rat serum and the in vivo transformation pathways of these absorbed constituents were proposed. Besides, we have established novel quantitative methodology of five crucial components of BHGZD and have monitored the pharmacokinetic behaviors of these constituents spontaneously in rat serum after BHGZD gavage. After rats received two ways of BHGZD gavage, the pharmacokinetic behaviors of each compound exhibited relatively similar behaviors, as evidenced by similar curve track as well as relatively close time to reach maximum concentration (Tmax) and half washout time (T1/2). Whereas the maximum plasma concentration (Cmax) and area under the plasma concentration-time curve (AUC) values of five analytes with multiple dosage were a bit higher than single dosage.This study added knowledge into the material basis and bio-transformation patterns of BHGZD in vivo, which would be of great value for exploring pharmacological effects and mechanism of BHGZD." @default.
• W4301397767 created "2022-10-05" @default.
• W4301397767 creator A5009452180 @default.
• W4301397767 creator A5012628393 @default.
• W4301397767 creator A5013393140 @default.
• W4301397767 creator A5020059768 @default.
• W4301397767 creator A5052308910 @default.
• W4301397767 creator A5057054017 @default.
• W4301397767 creator A5074583120 @default.
• W4301397767 creator A5081239726 @default.
• W4301397767 creator A5086326013 @default.
• W4301397767 creator A5089215870 @default.
• W4301397767 date "2022-10-04" @default.
• W4301397767 modified "2023-10-09" @default.
• W4301397767 title "Metabolic profiling and pharmacokinetic studies of Baihu-Guizhi decoction in rats by UFLC-Q-TOF–MS/MS and UHPLC-Q-TRAP-MS/MS" @default.
• W4301397767 cites W1556863176 @default.
• W4301397767 cites W1992336016 @default.
• W4301397767 cites W2008053770 @default.
• W4301397767 cites W2009192664 @default.
• W4301397767 cites W2018358520 @default.
• W4301397767 cites W2027435326 @default.
• W4301397767 cites W2041586315 @default.
• W4301397767 cites W2381044398 @default.
• W4301397767 cites W2572858162 @default.
• W4301397767 cites W2651958066 @default.
• W4301397767 cites W2886070608 @default.
• W4301397767 cites W2898393362 @default.
• W4301397767 cites W2909330530 @default.
• W4301397767 cites W2914966375 @default.
• W4301397767 cites W2932782194 @default.
• W4301397767 cites W2965347066 @default.
• W4301397767 cites W2992519216 @default.
• W4301397767 cites W2996833068 @default.
• W4301397767 cites W2997013618 @default.
• W4301397767 cites W3007505839 @default.
• W4301397767 cites W3007596014 @default.
• W4301397767 cites W3014899284 @default.
• W4301397767 cites W3026204554 @default.
• W4301397767 cites W3041189192 @default.
• W4301397767 cites W3107088162 @default.
• W4301397767 cites W3112006208 @default.
• W4301397767 cites W3163952303 @default.
• W4301397767 cites W3203486699 @default.
• W4301397767 doi "https://doi.org/10.1186/s13020-022-00665-w" @default.
• W4301397767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36195951" @default.
• W4301397767 hasPublicationYear "2022" @default.
• W4301397767 type Work @default.
• W4301397767 citedByCount "2" @default.
• W4301397767 countsByYear W43013977672023 @default.
• W4301397767 crossrefType "journal-article" @default.
• W4301397767 hasAuthorship W4301397767A5009452180 @default.
• W4301397767 hasAuthorship W4301397767A5012628393 @default.
• W4301397767 hasAuthorship W4301397767A5013393140 @default.
• W4301397767 hasAuthorship W4301397767A5020059768 @default.
• W4301397767 hasAuthorship W4301397767A5052308910 @default.
• W4301397767 hasAuthorship W4301397767A5057054017 @default.
• W4301397767 hasAuthorship W4301397767A5074583120 @default.
• W4301397767 hasAuthorship W4301397767A5081239726 @default.
• W4301397767 hasAuthorship W4301397767A5086326013 @default.
• W4301397767 hasAuthorship W4301397767A5089215870 @default.
• W4301397767 hasBestOaLocation W43013977671 @default.
• W4301397767 hasConcept C106289968 @default.
• W4301397767 hasConcept C112705442 @default.
• W4301397767 hasConcept C150903083 @default.
• W4301397767 hasConcept C162356407 @default.
• W4301397767 hasConcept C172493649 @default.
• W4301397767 hasConcept C185592680 @default.
• W4301397767 hasConcept C190409667 @default.
• W4301397767 hasConcept C207001950 @default.
• W4301397767 hasConcept C22979827 @default.
• W4301397767 hasConcept C27826464 @default.
• W4301397767 hasConcept C31827203 @default.
• W4301397767 hasConcept C43617362 @default.
• W4301397767 hasConcept C556039675 @default.
• W4301397767 hasConcept C64489805 @default.
• W4301397767 hasConcept C69366308 @default.
• W4301397767 hasConcept C71043704 @default.
• W4301397767 hasConcept C71924100 @default.
• W4301397767 hasConcept C86803240 @default.
• W4301397767 hasConcept C98274493 @default.
• W4301397767 hasConceptScore W4301397767C106289968 @default.
• W4301397767 hasConceptScore W4301397767C112705442 @default.
• W4301397767 hasConceptScore W4301397767C150903083 @default.
• W4301397767 hasConceptScore W4301397767C162356407 @default.
• W4301397767 hasConceptScore W4301397767C172493649 @default.
• W4301397767 hasConceptScore W4301397767C185592680 @default.
• W4301397767 hasConceptScore W4301397767C190409667 @default.
• W4301397767 hasConceptScore W4301397767C207001950 @default.
• W4301397767 hasConceptScore W4301397767C22979827 @default.
• W4301397767 hasConceptScore W4301397767C27826464 @default.
• W4301397767 hasConceptScore W4301397767C31827203 @default.
• W4301397767 hasConceptScore W4301397767C43617362 @default.
• W4301397767 hasConceptScore W4301397767C556039675 @default.
• W4301397767 hasConceptScore W4301397767C64489805 @default.
• W4301397767 hasConceptScore W4301397767C69366308 @default.
• W4301397767 hasConceptScore W4301397767C71043704 @default.
• W4301397767 hasConceptScore W4301397767C71924100 @default.
• W4301397767 hasConceptScore W4301397767C86803240 @default.
• W4301397767 hasConceptScore W4301397767C98274493 @default.
• W4301397767 hasFunder F4320321001 @default.

• next