Matches in SemOpenAlex for { <https://semopenalex.org/work/W4301401102> ?p ?o ?g. }
- W4301401102 abstract "Amyloid beta (Aβ) deposits in the retina of the Alzheimer's disease (AD) eye may provide a useful diagnostic biomarker for AD. This study focused on the relationship of Aβ with macroglia and microglia, as these glial cells are hypothesized to play important roles in homeostasis and clearance of Aβ in the AD retina. Significantly higher Aβ load was found in AD compared to controls, and specifically in the mid-peripheral region. AD retina showed significantly less immunoreactivity against glial fibrillary acidic protein (GFAP) and glutamine synthetase (GS) compared to control eyes. Immunoreactivity against ionized calcium binding adapter molecule-1 (IBA-1), a microglial marker, demonstrated a higher level of microgliosis in AD compared to control retina. Within AD retina, more IBA-1 immunoreactivity was present in the mid-peripheral retina, which contained more Aβ than the central AD retina. GFAP co-localized rarely with Aβ, while IBA-1 co-localized with Aβ in more layers of control than AD donor retina. These results suggest that dysfunction of the Müller and microglial cells may be key features of the AD retina." @default.
- W4301401102 created "2022-10-05" @default.
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- W4301401102 date "2022-10-05" @default.
- W4301401102 modified "2023-10-05" @default.
- W4301401102 title "Müller cell degeneration and microglial dysfunction in the Alzheimer’s retina" @default.
- W4301401102 cites W1488074945 @default.
- W4301401102 cites W1593213689 @default.
- W4301401102 cites W1601380713 @default.
- W4301401102 cites W1800233527 @default.
- W4301401102 cites W1898743042 @default.
- W4301401102 cites W1925629371 @default.
- W4301401102 cites W1964602001 @default.
- W4301401102 cites W1966483452 @default.
- W4301401102 cites W1973500410 @default.
- W4301401102 cites W1973953770 @default.
- W4301401102 cites W1974626393 @default.
- W4301401102 cites W1979474933 @default.
- W4301401102 cites W1981433882 @default.
- W4301401102 cites W1981837445 @default.
- W4301401102 cites W1982636709 @default.
- W4301401102 cites W1988100039 @default.
- W4301401102 cites W1996006216 @default.
- W4301401102 cites W2005483591 @default.
- W4301401102 cites W2006867636 @default.
- W4301401102 cites W2018708829 @default.
- W4301401102 cites W2024670087 @default.
- W4301401102 cites W2028884948 @default.
- W4301401102 cites W2029676821 @default.
- W4301401102 cites W2030349544 @default.
- W4301401102 cites W2030508474 @default.
- W4301401102 cites W2035351488 @default.
- W4301401102 cites W2047202120 @default.
- W4301401102 cites W2048889423 @default.
- W4301401102 cites W2048975745 @default.
- W4301401102 cites W2053288220 @default.
- W4301401102 cites W2058824832 @default.
- W4301401102 cites W2065009648 @default.
- W4301401102 cites W2067357578 @default.
- W4301401102 cites W2072210142 @default.
- W4301401102 cites W2082414904 @default.
- W4301401102 cites W2085548462 @default.
- W4301401102 cites W2088033971 @default.
- W4301401102 cites W2093442070 @default.
- W4301401102 cites W2094805317 @default.
- W4301401102 cites W2095555365 @default.
- W4301401102 cites W2115642128 @default.
- W4301401102 cites W2116784956 @default.
- W4301401102 cites W2127890285 @default.
- W4301401102 cites W2133719476 @default.
- W4301401102 cites W2143461767 @default.
- W4301401102 cites W2149347131 @default.
- W4301401102 cites W2167840686 @default.
- W4301401102 cites W2205048710 @default.
- W4301401102 cites W2208088507 @default.
- W4301401102 cites W2293863006 @default.
- W4301401102 cites W2327547544 @default.
- W4301401102 cites W2329336071 @default.
- W4301401102 cites W2406832004 @default.
- W4301401102 cites W2521439892 @default.
- W4301401102 cites W2535166298 @default.
- W4301401102 cites W2551410102 @default.
- W4301401102 cites W2554599497 @default.
- W4301401102 cites W2565129117 @default.
- W4301401102 cites W2592718795 @default.
- W4301401102 cites W2599047051 @default.
- W4301401102 cites W2624217674 @default.
- W4301401102 cites W2728593064 @default.
- W4301401102 cites W2750510345 @default.
- W4301401102 cites W2781705645 @default.
- W4301401102 cites W2784559594 @default.
- W4301401102 cites W2796108391 @default.
- W4301401102 cites W2884116403 @default.
- W4301401102 cites W2887893776 @default.
- W4301401102 cites W2897741792 @default.
- W4301401102 cites W2908109475 @default.
- W4301401102 cites W2968677052 @default.
- W4301401102 cites W2969371707 @default.
- W4301401102 cites W2973454555 @default.
- W4301401102 cites W2978698290 @default.
- W4301401102 cites W2993468802 @default.
- W4301401102 cites W2999860703 @default.
- W4301401102 cites W3005292279 @default.
- W4301401102 cites W3046594016 @default.