FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4301401320> ?p ?o ?g. }

• W4301401320 abstract "Acute Kidney Injury (AKI) is a very frequent condition, occurring in about one in three patients admitted to an intensive care unit (ICU). AKI is a syndrome defined as a sudden decrease in glomerular filtration rate. However, this unified definition does not reflect the various mechanisms involved in AKI pathophysiology, each with its own characteristics and sensitivity to therapy. In this study, we aimed at developing an innovative machine learning based method able to subphenotype AKI according to its pattern of risk factors.We adopted a three-step pipeline of analyses. First, we looked for factors associated with AKI using a generalized additive model. Second, we calculated the importance of each identified AKI related factor in the estimated AKI risk to find the main risk factor for AKI, at the single patient level. Lastly, we clusterized AKI patients according to their profile of risk factors and compared the clinical characteristics and outcome of every cluster. We applied this method to a cohort of severe COVID-19 patients hospitalized in the ICU of the Geneva University Hospitals.Among the 248 patients analyzed, we found 7 factors associated with AKI development. Using the individual expression of these factors, we identified three groups of AKI patients, based on the use of Lopinavir/Ritonavir, baseline eGFR, use of dexamethasone and AKI severity. The three clusters expressed distinct characteristics in terms of AKI severity and recovery, metabolic patterns and hospital mortality.We propose here a new method to phenotype AKI patients according to their most important individual risk factors for AKI development. When applied to an ICU cohort of COVID-19 patients, we were able to differentiate three groups of patients. Each expressed specific AKI characteristics and outcomes, which probably reflect a distinct pathophysiology." @default.
• W4301401320 created "2022-10-05" @default.
• W4301401320 creator A5018048111 @default.
• W4301401320 creator A5026030757 @default.
• W4301401320 creator A5034847674 @default.
• W4301401320 creator A5038748398 @default.
• W4301401320 creator A5048027483 @default.
• W4301401320 creator A5056099545 @default.
• W4301401320 creator A5060583052 @default.
• W4301401320 creator A5077352717 @default.
• W4301401320 date "2022-10-05" @default.
• W4301401320 modified "2023-09-27" @default.
• W4301401320 title "Unsupervised clustering reveals phenotypes of AKI in ICU COVID-19 patients" @default.
• W4301401320 cites W1972649334 @default.
• W4301401320 cites W1985454213 @default.
• W4301401320 cites W2030452462 @default.
• W4301401320 cites W2035504997 @default.
• W4301401320 cites W2052770544 @default.
• W4301401320 cites W2062045131 @default.
• W4301401320 cites W2126382068 @default.
• W4301401320 cites W2133774108 @default.
• W4301401320 cites W2134732827 @default.
• W4301401320 cites W2141559993 @default.
• W4301401320 cites W2145136986 @default.
• W4301401320 cites W2165721742 @default.
• W4301401320 cites W2338250914 @default.
• W4301401320 cites W2380810418 @default.
• W4301401320 cites W2520697268 @default.
• W4301401320 cites W2554008835 @default.
• W4301401320 cites W2586582651 @default.
• W4301401320 cites W2613520124 @default.
• W4301401320 cites W2618408467 @default.
• W4301401320 cites W2804227301 @default.
• W4301401320 cites W2891681115 @default.
• W4301401320 cites W2896124705 @default.
• W4301401320 cites W2896434545 @default.
• W4301401320 cites W2914683543 @default.
• W4301401320 cites W2944028175 @default.
• W4301401320 cites W2990390432 @default.
• W4301401320 cites W3016688585 @default.
• W4301401320 cites W3025305522 @default.
• W4301401320 cites W3035028018 @default.
• W4301401320 cites W3039963761 @default.
• W4301401320 cites W3041242936 @default.
• W4301401320 cites W3042687084 @default.
• W4301401320 cites W3043510618 @default.
• W4301401320 cites W3045448162 @default.
• W4301401320 cites W3048084452 @default.
• W4301401320 cites W3091997194 @default.
• W4301401320 cites W3092169312 @default.
• W4301401320 cites W3092326142 @default.
• W4301401320 cites W3111747080 @default.
• W4301401320 cites W3132057842 @default.
• W4301401320 cites W3139812053 @default.
• W4301401320 cites W3144222490 @default.
• W4301401320 cites W3162051708 @default.
• W4301401320 cites W3164458620 @default.
• W4301401320 cites W3166154243 @default.
• W4301401320 cites W3179164182 @default.
• W4301401320 cites W3180262708 @default.
• W4301401320 cites W3200277804 @default.
• W4301401320 cites W4200199866 @default.
• W4301401320 cites W4206581029 @default.
• W4301401320 cites W4225746562 @default.
• W4301401320 cites W4226409442 @default.
• W4301401320 cites W4285794641 @default.
• W4301401320 doi "https://doi.org/10.3389/fmed.2022.980160" @default.
• W4301401320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36275817" @default.
• W4301401320 hasPublicationYear "2022" @default.
• W4301401320 type Work @default.
• W4301401320 citedByCount "0" @default.
• W4301401320 crossrefType "journal-article" @default.
• W4301401320 hasAuthorship W4301401320A5018048111 @default.
• W4301401320 hasAuthorship W4301401320A5026030757 @default.
• W4301401320 hasAuthorship W4301401320A5034847674 @default.
• W4301401320 hasAuthorship W4301401320A5038748398 @default.
• W4301401320 hasAuthorship W4301401320A5048027483 @default.
• W4301401320 hasAuthorship W4301401320A5056099545 @default.
• W4301401320 hasAuthorship W4301401320A5060583052 @default.
• W4301401320 hasAuthorship W4301401320A5077352717 @default.
• W4301401320 hasBestOaLocation W43014013201 @default.
• W4301401320 hasConcept C126322002 @default.
• W4301401320 hasConcept C159641895 @default.
• W4301401320 hasConcept C177713679 @default.
• W4301401320 hasConcept C2776376669 @default.
• W4301401320 hasConcept C2780472472 @default.
• W4301401320 hasConcept C50440223 @default.
• W4301401320 hasConcept C71924100 @default.
• W4301401320 hasConceptScore W4301401320C126322002 @default.
• W4301401320 hasConceptScore W4301401320C159641895 @default.
• W4301401320 hasConceptScore W4301401320C177713679 @default.
• W4301401320 hasConceptScore W4301401320C2776376669 @default.
• W4301401320 hasConceptScore W4301401320C2780472472 @default.
• W4301401320 hasConceptScore W4301401320C50440223 @default.
• W4301401320 hasConceptScore W4301401320C71924100 @default.
• W4301401320 hasFunder F4320323829 @default.
• W4301401320 hasFunder F4320324574 @default.
• W4301401320 hasLocation W43014013201 @default.
• W4301401320 hasLocation W43014013202 @default.
• W4301401320 hasLocation W43014013203 @default.

• next