Matches in SemOpenAlex for { <https://semopenalex.org/work/W4301401618> ?p ?o ?g. }
- W4301401618 endingPage "113450" @default.
- W4301401618 startingPage "113450" @default.
- W4301401618 abstract "Prostate cancer (PCa) cells exploit cellular metabolic reprogramming as their survival advantage, especially aberrant lipid signaling and metabolism. Although recent studies deemed that PCa tends to rely on lipid fuel in comparison with aerobic glycolysis, the relationship between lipid metabolism and cancer growth remains unknown. We demonstrated that wogonin, a naturally occurring mono-flavonoid, could induce apoptosis of PCa cells in vivo and in vitro. Mechanistically, 100 μM wogonin significantly increased the expression of proteins related to the fatty acid synthesis and accumulation as a result of stimulation of AKT phosphorylation and nuclear accumulation of sterol regulatory element-binding protein 1 (SREBP1). The wogonin-induced up-regulation of fatty acid synthase (FASN) promoted fatty acid synthesis and storage, while increased oxidation in mitochondria driven by carnitine palmitoyl-transferase 1A (CPT1A) resulted in the loss of mitochondrial membrane potential and reactive oxygen species (ROS) accumulation, ultimately inducing apoptosis in DU145 and 22Rv1 cells. In vivo, 100 mg/kg of wogonin (i.v.) significantly repressed tumor growth without any obvious toxicity in the PCa xenograft model. In short, we proved that wogonin regulated the fatty acid metabolism and induced apoptosis by activating the AKT-SREBP1-FASN signaling network in human PCa cells, and it exhibited potent anti-tumor effects both in vivo and vitro. Thus it might be a promising candidate for the development of anti-cancer drugs." @default.
- W4301401618 created "2022-10-05" @default.
- W4301401618 creator A5024822456 @default.
- W4301401618 creator A5026066382 @default.
- W4301401618 creator A5043095144 @default.
- W4301401618 creator A5046915206 @default.
- W4301401618 creator A5069499803 @default.
- W4301401618 creator A5079885056 @default.
- W4301401618 creator A5083151551 @default.
- W4301401618 date "2022-11-01" @default.
- W4301401618 modified "2023-10-16" @default.
- W4301401618 title "Apoptosis induction in human prostate cancer cells related to the fatty acid metabolism by wogonin-mediated regulation of the AKT-SREBP1-FASN signaling network" @default.
- W4301401618 cites W1181063662 @default.
- W4301401618 cites W1980568044 @default.
- W4301401618 cites W1983259239 @default.
- W4301401618 cites W1983457010 @default.
- W4301401618 cites W1987126302 @default.
- W4301401618 cites W1988117658 @default.
- W4301401618 cites W1989107036 @default.
- W4301401618 cites W1989466994 @default.
- W4301401618 cites W1991780368 @default.
- W4301401618 cites W1995759254 @default.
- W4301401618 cites W1998265194 @default.
- W4301401618 cites W2003287009 @default.
- W4301401618 cites W2005084937 @default.
- W4301401618 cites W2011574523 @default.
- W4301401618 cites W2014999693 @default.
- W4301401618 cites W2017399995 @default.
- W4301401618 cites W2023947368 @default.
- W4301401618 cites W2029465413 @default.
- W4301401618 cites W2035703541 @default.
- W4301401618 cites W2042401267 @default.
- W4301401618 cites W2051823539 @default.
- W4301401618 cites W2056040807 @default.
- W4301401618 cites W2058168165 @default.
- W4301401618 cites W2062785709 @default.
- W4301401618 cites W2064030869 @default.
- W4301401618 cites W2080193116 @default.
- W4301401618 cites W2086453930 @default.
- W4301401618 cites W2090846942 @default.
- W4301401618 cites W2091731411 @default.
- W4301401618 cites W2091853487 @default.
- W4301401618 cites W2093273210 @default.
- W4301401618 cites W2099711117 @default.
- W4301401618 cites W2102368033 @default.
- W4301401618 cites W2105904136 @default.
- W4301401618 cites W2113334939 @default.
- W4301401618 cites W2126909426 @default.
- W4301401618 cites W2127825296 @default.
- W4301401618 cites W2415945663 @default.
- W4301401618 cites W2527752606 @default.
- W4301401618 cites W2589583989 @default.
- W4301401618 cites W2604669175 @default.
- W4301401618 cites W2626932481 @default.
- W4301401618 cites W2775692160 @default.
- W4301401618 cites W2794230833 @default.
- W4301401618 cites W2804736643 @default.
- W4301401618 cites W2885824319 @default.
- W4301401618 cites W2903158198 @default.
- W4301401618 cites W2903662205 @default.
- W4301401618 cites W2904907708 @default.
- W4301401618 cites W2911188335 @default.
- W4301401618 cites W2912991678 @default.
- W4301401618 cites W2921877300 @default.
- W4301401618 cites W2964504012 @default.
- W4301401618 cites W2996717182 @default.
- W4301401618 cites W2997840987 @default.
- W4301401618 cites W3007837833 @default.
- W4301401618 cites W3009220429 @default.
- W4301401618 cites W3018249938 @default.
- W4301401618 cites W3099938019 @default.
- W4301401618 cites W3109926818 @default.
- W4301401618 cites W3150683237 @default.
- W4301401618 cites W3165027862 @default.
- W4301401618 cites W3194620927 @default.
- W4301401618 cites W3211281229 @default.
- W4301401618 cites W4243903519 @default.
- W4301401618 cites W4382678090 @default.
- W4301401618 doi "https://doi.org/10.1016/j.fct.2022.113450" @default.
- W4301401618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36208653" @default.
- W4301401618 hasPublicationYear "2022" @default.
- W4301401618 type Work @default.
- W4301401618 citedByCount "4" @default.
- W4301401618 countsByYear W43014016182023 @default.
- W4301401618 crossrefType "journal-article" @default.
- W4301401618 hasAuthorship W4301401618A5024822456 @default.
- W4301401618 hasAuthorship W4301401618A5026066382 @default.
- W4301401618 hasAuthorship W4301401618A5043095144 @default.
- W4301401618 hasAuthorship W4301401618A5046915206 @default.
- W4301401618 hasAuthorship W4301401618A5069499803 @default.
- W4301401618 hasAuthorship W4301401618A5079885056 @default.
- W4301401618 hasAuthorship W4301401618A5083151551 @default.
- W4301401618 hasConcept C121608353 @default.
- W4301401618 hasConcept C142724271 @default.
- W4301401618 hasConcept C185592680 @default.
- W4301401618 hasConcept C188947578 @default.
- W4301401618 hasConcept C190283241 @default.
- W4301401618 hasConcept C204787440 @default.