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- W4301404313 abstract "About 15 different guinea pig testing methods are available in the literature. The methods have certain features in common: an induction phase, followed by a resting period of about 2 weeks, and a subsequent challenge phase to prove whether or not sensitization has occurred. The technical variations of the methods have been introduced to increase their sensitivity and to make them applicable for testing of different substances. There is no simple answer to the question of which test to use. Guinea pig test results must be carefully evaluated and interpreted with caution because of the limitations introduced when one extrapolates from a laboratory animal species to humans. The results depend on choice of animal strain, technical details, induction and challenge concentration, vehicle, and reading. Further standardization of the test methods is desirable." @default.
- W4301404313 created "2022-10-05" @default.
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- W4301404313 date "1989-12-01" @default.
- W4301404313 modified "2023-10-16" @default.
- W4301404313 title "Utilization of Guinea Pig Sensitization Data in Office Practice" @default.
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- W4301404313 doi "https://doi.org/10.1016/s0889-8561(22)00237-5" @default.
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