FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4301440502> ?p ?o ?g. }

• W4301440502 abstract "Background Regarding the pharmacological treatment of psychotic depression there is uncertainty about the effectiveness of an antidepressant alone compared to the combination of an antidepressant and an antipsychotic. Objectives To compare the clinical effectiveness of pharmacological treatments for patients with a psychotic depression: antidepressant monotherapy, antipsychotic monotherapy, and the combination of an antidepressant and an antipsychotic, compared with each other and/or with placebo. Search methods (1) The Cochrane Central Register of Controlled Trials (CENTRAL) was screened with the terms depressive disorder and drug treatment (April 2004). (2) MEDLINE (1966 to April 2004) and EMBASE (1980 to April 2004) were searched using terms with regard to treatment of unipolar psychotic depression. (3) Reference lists of related reviews and reference lists of all identified studies were searched. (4) Personal communications. Selection criteria All randomised controlled trials (RCTs) with patients with major depression with psychotic features as well as RCTs with patients with major depression with or without psychotic features which reported on the subgroup of patients with psychotic features separately. Data collection and analysis Two reviewers assessed the methodological quality of the included studies, according to the Cochrane Handbook criteria. Data were entered into RevMan 4.2.5. We used intention‐to‐treat data. For dichotomous efficacy outcomes, the relative risk with 95% confidence intervals (CI) was calculated. For continuously distributed outcomes, it was not possible to extract data from the RCTs. Regarding the primary harm outcome, only overall drop‐out rates were available for all studies. Main results The search identified 3333 abstracts, but only 10 RCTs with a total of 548 patients could be included in the review. Due to clinical heterogeneity, few meta‐analyses were possible. We found no conclusive evidence that the combination of an antidepressant and an antipsychotic is more effective than an antidepressant alone (two RCTs; RR 1.44, 95% CI 0.86 to 2.41), but a combination is more effective than an antipsychotic alone (three RCTs; RR 1.92, 95% CI 1.32 to 2.80). There were no statistically significant differences in the overall drop‐out rates between any of the treatments, neither in individual studies nor after pooling of studies. Authors' conclusions Treatment with an antipsychotic alone is not a good option. Starting with an antidepressant alone and adding an antipsychotic if the patient does not respond or starting with the combination of an antidepressant and an antipsychotic both appear appropriate options for patients with psychotic depression. In clinical practice the balance between risks and benefits suggests that initial antidepressive monotherapy and adding an antipsychotic if there is inadequate response should be the preferred treatment strategy for many patients. The general lack of available data limits confidence in the conclusions drawn." @default.
• W4301440502 created "2022-10-05" @default.
• W4301440502 creator A5010787519 @default.
• W4301440502 creator A5028672022 @default.
• W4301440502 creator A5053073743 @default.
• W4301440502 creator A5074939684 @default.
• W4301440502 creator A5090875089 @default.
• W4301440502 date "2005-10-19" @default.
• W4301440502 modified "2023-10-01" @default.
• W4301440502 title "Pharmacological treatment for psychotic depression" @default.
• W4301440502 cites W106994774 @default.
• W4301440502 cites W1967122944 @default.
• W4301440502 cites W1993336298 @default.
• W4301440502 cites W1994550766 @default.
• W4301440502 cites W1997848737 @default.
• W4301440502 cites W1999329221 @default.
• W4301440502 cites W2003686806 @default.
• W4301440502 cites W2010138051 @default.
• W4301440502 cites W2017839861 @default.
• W4301440502 cites W2018522847 @default.
• W4301440502 cites W2020550765 @default.
• W4301440502 cites W2024115155 @default.
• W4301440502 cites W2035716594 @default.
• W4301440502 cites W2049541785 @default.
• W4301440502 cites W2055835842 @default.
• W4301440502 cites W2060568618 @default.
• W4301440502 cites W2076364224 @default.
• W4301440502 cites W2083418835 @default.
• W4301440502 cites W2084066211 @default.
• W4301440502 cites W2151997282 @default.
• W4301440502 cites W2153074711 @default.
• W4301440502 cites W2321329826 @default.
• W4301440502 cites W2329589463 @default.
• W4301440502 cites W2332984098 @default.
• W4301440502 cites W2396399921 @default.
• W4301440502 cites W2464692596 @default.
• W4301440502 cites W4230702754 @default.
• W4301440502 cites W4244103373 @default.
• W4301440502 cites W4254902595 @default.
• W4301440502 cites W89007775 @default.
• W4301440502 doi "https://doi.org/10.1002/14651858.cd004044.pub2" @default.
• W4301440502 hasPublicationYear "2005" @default.
• W4301440502 type Work @default.
• W4301440502 citedByCount "25" @default.
• W4301440502 countsByYear W43014405022012 @default.
• W4301440502 countsByYear W43014405022013 @default.
• W4301440502 countsByYear W43014405022014 @default.
• W4301440502 countsByYear W43014405022015 @default.
• W4301440502 countsByYear W43014405022017 @default.
• W4301440502 countsByYear W43014405022019 @default.
• W4301440502 countsByYear W43014405022020 @default.
• W4301440502 countsByYear W43014405022021 @default.
• W4301440502 crossrefType "reference-entry" @default.
• W4301440502 hasAuthorship W4301440502A5010787519 @default.
• W4301440502 hasAuthorship W4301440502A5028672022 @default.
• W4301440502 hasAuthorship W4301440502A5053073743 @default.
• W4301440502 hasAuthorship W4301440502A5074939684 @default.
• W4301440502 hasAuthorship W4301440502A5090875089 @default.
• W4301440502 hasBestOaLocation W43014405022 @default.
• W4301440502 hasConcept C118552586 @default.
• W4301440502 hasConcept C126322002 @default.
• W4301440502 hasConcept C139719470 @default.
• W4301440502 hasConcept C142724271 @default.
• W4301440502 hasConcept C162324750 @default.
• W4301440502 hasConcept C168563851 @default.
• W4301440502 hasConcept C17744445 @default.
• W4301440502 hasConcept C199539241 @default.
• W4301440502 hasConcept C204787440 @default.
• W4301440502 hasConcept C27081682 @default.
• W4301440502 hasConcept C2776412080 @default.
• W4301440502 hasConcept C2776867660 @default.
• W4301440502 hasConcept C2779177272 @default.
• W4301440502 hasConcept C2779473830 @default.
• W4301440502 hasConcept C2779727114 @default.
• W4301440502 hasConcept C2780163958 @default.
• W4301440502 hasConcept C2780494398 @default.
• W4301440502 hasConcept C44249647 @default.
• W4301440502 hasConcept C558461103 @default.
• W4301440502 hasConcept C71924100 @default.
• W4301440502 hasConcept C82789193 @default.
• W4301440502 hasConcept C95190672 @default.
• W4301440502 hasConceptScore W4301440502C118552586 @default.
• W4301440502 hasConceptScore W4301440502C126322002 @default.
• W4301440502 hasConceptScore W4301440502C139719470 @default.
• W4301440502 hasConceptScore W4301440502C142724271 @default.
• W4301440502 hasConceptScore W4301440502C162324750 @default.
• W4301440502 hasConceptScore W4301440502C168563851 @default.
• W4301440502 hasConceptScore W4301440502C17744445 @default.
• W4301440502 hasConceptScore W4301440502C199539241 @default.
• W4301440502 hasConceptScore W4301440502C204787440 @default.
• W4301440502 hasConceptScore W4301440502C27081682 @default.
• W4301440502 hasConceptScore W4301440502C2776412080 @default.
• W4301440502 hasConceptScore W4301440502C2776867660 @default.
• W4301440502 hasConceptScore W4301440502C2779177272 @default.
• W4301440502 hasConceptScore W4301440502C2779473830 @default.
• W4301440502 hasConceptScore W4301440502C2779727114 @default.
• W4301440502 hasConceptScore W4301440502C2780163958 @default.
• W4301440502 hasConceptScore W4301440502C2780494398 @default.
• W4301440502 hasConceptScore W4301440502C44249647 @default.
• W4301440502 hasConceptScore W4301440502C558461103 @default.

• next