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- W4301471146 abstract "One way to understand the role history plays on evolutionary trajectories is by giving ancient life a second opportunity to evolve. Our ability to empirically perform such an experiment, however, is limited by current experimental designs. Combining ancestral sequence reconstruction with synthetic biology allows us to resurrect the past within a modern context and has expanded our understanding of protein functionality within a historical context. Experimental evolution, on the other hand, provides us with the ability to study evolution in action, under controlled conditions in the laboratory. Here we describe a novel experimental setup that integrates two disparate fields - ancestral sequence reconstruction and experimental evolution. This allows us to rewind and replay the evolutionary history of ancient biomolecules in the laboratory. We anticipate that our combination will provide a deeper understanding of the underlying roles that contingency and determinism play in shaping evolutionary processes." @default.
- W4301471146 created "2022-10-05" @default.
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- W4301471146 date "2012-09-22" @default.
- W4301471146 modified "2023-10-14" @default.
- W4301471146 title "Towards the Recapitulation of Ancient History in the Laboratory: Combining Synthetic Biology with Experimental Evolution" @default.
- W4301471146 doi "https://doi.org/10.48550/arxiv.1209.5032" @default.
- W4301471146 hasPublicationYear "2012" @default.
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