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• W4301492701 abstract "Preliminary data from our laboratory have shown that the decrease in plasma free carnitine levels normally found during prolonged exercise is blunted in type 1 diabetic man. This study was designed to test the hypothesis that this might be due to the sustained peripheral hyperinsulinemia seen during exercise in diabetics treated by subcutaneous insulin. Ten male subjects underwent 90 min of cycle ergometry at 60% of their maximal oxygen uptake capacity on two occasions, one with and the other without a constant 0.13 mU∙kg −1 ∙min −1 i.v. insulin infusion. Blood samples were taken at rest, during exercise, and after exercise for measurement of plasma glucose, insulin, C-peptide, free fatty acids, and carnitine. Plasma glucose dropped significantly (p < 0.01) from basal during both infusions, but values at 30, 45, and 60 min of exercise were lower (p < 0.05) during insulin infusion compared with the saline infusion. Exercise produced a significant (p < 0.01) fall in plasma insulin in both infusions. However, from 30 to 90 min of exercise, the plateau insulin level was higher during the insulin infusion compared with the saline infusion (91.4 ± 3.0 vs. 32.9 ± 3.0 pmol/L; p < 0.001). Plasma C-peptide decreased significantly (p < 0.01) during exercise and recovery in both infusions, but values between infusions were not significantly different. Plasma free fatty acids increased significantly (p < 0.01) at 90 min of exercise during the saline infusion, while during the insulin infusion this was noted during recovery only. Free fatty acid values at 75 (p < 0.05) and 90 min (p < 0.01) of exercise, and during recovery (p < 0.01), were lower during the insulin infusion than during the saline infusion. Plasma free carnitine declined (p < 0.01) during exercise and recovery. However, at 60 min of exercise and at 30 min of recovery, free carnitine levels were significantly (p < 0.05) lower during the saline infusion compared with the insulin infusion. The decrement in surface area below baseline in free carnitine was greater during the saline infusion than in the insulin infusion (−298 ± 52 vs. −133 ± 29 μmol∙L −1 ∙min −1 ; p < 0.01). Esterified carnitine increased (p < 0.01) similarly during both infusions. These data indicate that the fall in plasma free carnitine during exercise can be reduced by an exogenous insulin infusion in normal man. Indirectly, this suggests that the absence of a decline in plasma free carnitine during exercise in diabetics can be explained by their high insulin levels.Key words: insulin, free carnitine, free fatty acids, acute exercise." @default.
• W4301492701 created "2022-10-05" @default.
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• W4301492701 date "1989-12-01" @default.
• W4301492701 modified "2023-09-26" @default.
• W4301492701 title "Effect of exogenous insulin on plasma free carnitine levels during exercise in normal man" @default.
• W4301492701 doi "https://doi.org/10.1139/y89-257" @default.
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